DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and wwtr1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001032785.1	Gene:	wwtr1 / 568008	ZFINID:	ZDB-GENE-051101-1	Length:	391	Species:	Danio rerio

Alignment Length:	419	Identity:	91/419 - (21%)
Similarity:	142/419 - (33%)	Gaps:	104/419 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  3200 PASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVPPVAASATGGTRRSSI 3264
            |.|||::..:|:.:.|:.......:.||.||..|    .|||.|.     |........||..|.
Zfish    53 PDSGSHSRQSSADSGSLPPRVHFRSRSSPASLQL----PAGSVSG-----PSPGRLHSHTRHQSC 108

  Fly  3265 PVLISSTLGPSSASSATSATGNGAT-----SDATTTTGGPTRNFSSVDSNVSSETQ-TTTRPPRQ 3323
            .|.....|.|....:.|.   ||..     .:..||...|.::.:...:.:|...| :.|...:|
Zfish   109 DVAEELPLPPGWEMAFTP---NGQKYFLNHIEKITTWHDPRKSMTPSVAQLSLHNQVSNTASIQQ 170

  Fly  3324 RGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADGAESQSQH---NSSSTAAQVAVPQ 3385
            |.....|..|..|..|.                          :.|.||   .......||.|..
Zfish   171 RSMALSQPNLVLNQQAH--------------------------QQQQQHLQQQQQQVPVQVPVQA 209

  Fly  3386 HQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPN 3450
            .|:....|::..|.:..:...||...::         .|.|:|         |.....:......
Zfish   210 PQQQSSQPMMNLSAQQHQQKMRLQRIQM---------ERERIQ---------RRQEELMRQEVAL 256

  Fly  3451 RDLPACLQRHDHPAGSIFPRPSANRTPAPTLVSMPTPMSNAALEQLNVTAPDVVR---TDRN--- 3509
            |.||.       .:.::.|...|..:||.:..:||   :|:|...|| :.|...|   ||..
Zfish   257 RQLPM-------DSDNLPPVAPAIGSPAMSAGNMP---NNSADPFLN-SGPYHSREQSTDSGLGL 310

  Fly  3510 --FALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAED--DLWPGTVV 3570
              :::|::.|   |.|..:.|:       :..:.::|.....||....|     |  |..|||.|
Zfish   311 GCYSIPTTPE---DFLNNMEDM-------DTGENMVPVSMNVPPQSRFP-----DFLDSMPGTNV 360

  Fly  3571 SAGTREESSAPAVATESTEAVNESNQPEP 3599
            ..||.|.:....:..:....:|:|   ||
Zfish   361 DLGTLEGTDLMPILNDVESVLNKS---EP 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	5/25 (20%)
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
wwtr1	NP_001032785.1	WW	115..146	CDD:197736	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900