DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and plekha5

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_021330752.1 Gene:plekha5 / 567300 ZFINID:ZDB-GENE-041210-25 Length:1398 Species:Danio rerio


Alignment Length:1562 Identity:281/1562 - (17%)
Similarity:461/1562 - (29%) Gaps:581/1562 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  3245 SLVVPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPT--------- 3300
            :||.|.::..||      ..|.........|:.|.|::.||.   ||.||....||         
Zfish   109 NLVHPVLSRPAT------KAPEAEKKERPTSTMSEASNYTGG---SDYTTHPSSPTTRPSRSSKK 164

  Fly  3301 -RNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAE---------IDLTNEQDSEG---- 3351
             .||....:::.   :....|..:.|.|.:|......::.:         :....::..||    
Zfish   165 VHNFGKRSNSIK---RNPNAPVIKNGWLHKQDSTGMKMWKKRWFVLSDMCLFYYRDEKEEGILGS 226

  Fly  3352 --------------DRSTST---------------TTGTAADGAESQSQHNSSSTAAQVAVPQHQ 3387
                          |..|..               :|.||.| .||..:..|.:..|.       
Zfish   227 ILLPSFHISMLSVDDHITRKYAFKATHPNMRTYYFSTDTAKD-MESWMKVMSDAAMAH------- 283

  Fly  3388 RHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNRD 3452
                          |.|..||::.:|      |.::...:.....|...:|..   :.|...||:
Zfish   284 --------------SEPIRRLEKVKL------DSRVPQEMNNMLNHRVLTRPE---IQNNERNRE 325

  Fly  3453 LPACLQRHDHPAGSIFPRPSANRTPAPTLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSS-- 3515
               .|::.|..:     :||.........|||               ..|..|...|:.....  
Zfish   326 ---TLRQEDKKS-----KPSEKPQKDKDRVSM---------------QKDGERFSENYTHRQKDG 367

  Fly  3516 ----LEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLW----------P 3566
                |:.|::......|..:...|.|.|:.||      ........||.:.|.:          |
Zfish   368 ERYMLQKDLEKFVLQKDGEKYAVQKEGDKYLL------QKDGHKYTVHKDGDKYTLQRELEMYNP 426

  Fly  3567 GTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNPQAPSAEP------TPLEP-- 3623
                   .::....|......:....|..:|.|.|.|.|......:.....|      ..|:|  
Zfish   427 -------PKDAEKIPQKDARFSLVQKELEKPVPPPRSEEKYGFQKEGTIERPLTKINSIKLQPAQ 484

  Fly  3624 GAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDL-----EVPEGVDPSFLAAL 3683
            .||:.|:|     :::.........||..|  .|.||      |||     .||....|:     
Zfish   485 AAAIAAAV-----SSSRMMQKQVNGSGERA--GDRSP------GDLSTVRTSVPPPTQPA----- 531

  Fly  3684 PSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQA 3748
                                                  ||     |....|.....|::||..:.
Zfish   532 --------------------------------------PE-----PERSLSRTSSMQQLEQWVRT 553

  Fly  3749 AQTANPEDPVDTAAFFQNLPENL---RQAILTDMEES---------------QIA------SLPP 3789
            .:|..|:|...:...:|.||.|:   |..|:....|.               .:|      :|.|
Zfish   554 HRTRAPDDDTRSITSYQTLPRNMPSHRAQIVPRYPEGYRTLPRNMLRPDSICSVAGSVYDRALQP 618

  Fly  3790 ELAAEAQFLRRD--WESRNGARMDAH--------PPSNALSRFQTTLQSLDDTRWHSSI--WYDA 3842
            ....:.:.:|.|  |:.....:..||        |....:.:.   .:|:..:..|.|:  ::..
Zfish   619 STQEKRRSIRDDTMWQLYEWQQRQAHSRLGYGTLPSPKTMGQI---AESIPTSPSHGSLAGYHTF 680

  Fly  3843 SGN-----------AQPQHHQHTTIVHQH-PH----AHHAPNMGKPLALLMMEDENILLD----- 3886
            |.|           :.|......||..:| ||    ::.|.....|.|      :||...     
Zfish   681 SPNRPLNPDSRSELSSPVFRGDVTIERRHRPHLSKYSYPAERRAAPPA------QNITAQSLQGK 739

  Fly  3887 -PDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAG 3950
             |:.|..||:.|..:..::||:|.|.:.:                   :.:.|.|..|       
Zfish   740 TPEELTLLLIKLRRQQAELNSLREHTLAQ-------------------LMQLNLDATN------- 778

  Fly  3951 GKPEWLKLRVDAAFGY-----KSN---IFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLAK 4007
            .|.|.|...:.....|     |.|   ||:|:.:.|.||.    .||..|..:.         .:
Zfish   779 PKSEILSHHLQRNLMYLDSQMKENEPIIFMIHTMIENSAP----RPQLYQQQMS---------PE 830

  Fly  4008 HYPSS---FVPFNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVPPGGTLDFRS 4069
            .|..:   :.|...||.|:                                            .|
Zfish   831 EYRENTYMYRPEELDVDAK--------------------------------------------LS 851

  Fly  4070 RFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQTNAK 4134
            |.|....|.|.:.        :....|.....|.:.|...|:...::|   |:|..:|       
Zfish   852 RLCEQDKVVRTQE--------EKLQQLHREKHTLETALLSASQEIEMS---SENPAAV------- 898

  Fly  4135 NFWDVVLNIDQQTQVRLANVAQFPLTS------------QPAW-EWQPNTADFLSFSESPFGQLL 4186
                       |:.|:..:|.|..|.|            :.:| |:....|| ::.:::   .||
Zfish   899 -----------QSVVQQRDVLQSGLLSTCRELSRVSTELERSWREYDRLEAD-VTLAKT---NLL 948

  Fly  4187 EMLPYKVICRSPHLTDMLVKLLASLSTELPK------EEELLPLSDQMPPLVPIGPVQRAGAAAA 4245
            |.|                :.|.|..||.|.      ::||..:.|.|..|....|.:       
Zfish   949 EQL----------------EALGSPQTEPPSQKHVQIQKELWRIQDVMEALSKNKPKR------- 990

  Fly  4246 AAHPPPPQPPAENTATATEIGDGLAANIEEQASPASGNPASGD-----SNAGAKRTQLPTLSVAL 4305
              :|.|..|.|...:|..:..|.:.::......|...:...||     .|.|...|        .
Zfish   991 --NPEPSFPGANPLSTLHKSEDSVDSSCVPPRPPLPYSYEGGDRPPPLPNPGQPHT--------T 1045

  Fly  4306 PVTPSKPR-RKIYSKNFS-------------QLQLVIEV-------LTHQC------GTTEGLDN 4343
            ..||.:|. ||...:|.:             :|..|.||       .:.|.      |.|:|:..
Zfish  1046 RTTPHRPEDRKTAQRNGTHTGPDYRLYKSEPELTTVAEVDESNGEDKSEQTAEKEPPGVTKGIVY 1110

  Fly  4344 VAKLIVNLTQCSQASSAIFIQYLT-------------------AAI--LGLAEEV---RQAIQML 4384
            ...::...|:.....|:....|:|                   :|:  :....||   |.:::..
Zfish  1111 PVGVVSPRTKSPMPESSTIASYVTLRKTKKPDPRTCQPQDRPRSAVEQMSSGAEVGRTRMSVEEQ 1175

  Fly  4385 LNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVP-----TVSGASLLPNLAVHE--------GI 4436
            :..||.   ||.||  ..:.....|:.:.:.|:..     |:......|.::..|        .:
Zfish  1176 MERIRR---HQQGA--LRERRREDGSLSRSLSFTKDSTYYTLQARKKSPVISPDEQDERRDMTPV 1235

  Fly  4437 MQDRFTAEHVIISAPKNAKPTCELQLP-----------------SMKK-LMSNSSAQPYFLRTLK 4483
            .:|....:|.  .|.:|.:.|.| |||                 |||: |:.:.|.:|    .||
Zfish  1236 ERDTKHTKHP--DAEENCRDTKE-QLPAHTHLEIKDKASVTRSVSMKESLLKSVSPKP----VLK 1293

  Fly  4484 IFMQVRDMYE----------AQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSAS 4538
                 :|..|          .||.|.|...|..|..::::|..:.:.|.......|.:::....|
Zfish  1294 -----QDESECKLEYDRKLATQNSLQTAVMVRVGTEEDEEDEEEEQKDSVQQQEDSYELSNSKHS 1353

  Fly  4539 TI 4540
            |:
Zfish  1354 TL 1355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 15/83 (18%)
DUF4414 3675..3779 CDD:291075 17/106 (16%)
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
plekha5XP_021330752.1 WW 13..42 CDD:306827
WW 58..87 CDD:306827
PH_PEPP1_2_3 177..280 CDD:270068 15/103 (15%)
SMC_N 822..>983 CDD:330553 42/262 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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