DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and hectd2

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_009304826.1	Gene:	hectd2 / 562999	ZFINID:	ZDB-GENE-100405-3	Length:	756	Species:	Danio rerio

Alignment Length:	424	Identity:	129/424 - (30%)
Similarity:	201/424 - (47%)	Gaps:	65/424 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  4768 ILDFDVKRKYFQTELER----------LDEGIRREEHTVS-------VRRVTVFEDSFRVLYRLG 4815
            ||...||:...|.:.|:          :|:..||:...:|       |||:.:..||...|.| .
Zfish   354 ILSTVVKKAIIQRDSEQQMISMARQTLVDKVSRRQRVDMSLLFLNIKVRRLQLVSDSLDELSR-K 417

  Fly  4816 PEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINP-----SSH 4875
            ..:.|.:..:.|..|.|.|.|||.:||::::.|:||:..|.:|        ||:...     ||.
Zfish   418 RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHTDYGMF--------TYVKESQCYWFSSW 474

  Fly  4876 ANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKN 4940
            ...|: |.|:.||.::..||:::..|:..|....||.:|...:...|:::.     .|:..|..:
Zfish   475 KCDNY-SEFRLVGALMGLAVYNSITLDIRFPPCVYKKLLTPPIVPCDLDTP-----VGMATLTLD 533

  Fly  4941 DI------------STLGYE--------LTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQ 4985
            |:            ..|.||        .||....:|.||.:..:|||.|....||..|:.||||
Zfish   534 DLQQIMPDLAHGLGELLSYEGNVEEDFYTTFQVFQEELGVVKAYNLKPGGDKIPVTNLNRKEYVQ 598

  Fly  4986 LVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTS 5050
            |.....::.||.:|..||..||:.:...:.:.:...:|:|:|:.|.|::|:..|:...:|..|:.
Zfish   599 LYIDFLLNKSIYRQFAAFYHGFHSVCASNALMLLRPEEVEILVCGSPNLDMGSLQRVVQYEGYSK 663

  Fly  5051 KSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCA 5115
            ....|:.||..:.:|....:.|.|.|.||:.:||:.|...|       .|:|.:.|.|||.||.:
Zfish   664 TDPTIRAFWDVVLAFPLELQKKLLHFTTGSDRVPVGGMADL-------NFKISKIDVSTDWLPVS 721

  Fly  5116 HTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            ||||||:.||.|||..:||..|..||.. :||||
Zfish   722 HTCFNQICLPPYKSKKELRQKLTIAISN-AEGFG 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	118/384 (31%)
		HECTc	4820..5148	CDD:214523	109/352 (31%)
hectd2	XP_009304826.1	HECTc	397..754	CDD:238033	117/379 (31%)
hectd2	XP_009304826.1	HECTc	420..753	CDD:214523	109/354 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900