DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and yap1

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001132952.1 Gene:yap1 / 561411 ZFINID:ZDB-GENE-030131-9710 Length:442 Species:Danio rerio


Alignment Length:441 Identity:86/441 - (19%)
Similarity:150/441 - (34%) Gaps:88/441 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  3425 NRLQGSSGH-----TNSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPR--PSANRTPAPTLV 3482
            |:....:||     ...|.|...||.||..|            |..:|.|.  |...|....:..
Zfish     4 NQHNPPAGHQIVHVRGDSETDLEALFNAVMN------------PKNTIVPPSVPMRLRKLPDSFF 56

  Fly  3483 SMPTPMSNAALEQLNVTA-------PDVVRTDRNFALPSSLEVDVDVLPG-IVDLPQQEAQPE-- 3537
            :.|.|.|::  .|.:..|       |..||...:   |:||::.. |.|| :..:....|.|:  
Zfish    57 TPPEPKSHS--RQASTDAGTAGTVTPHHVRAHSS---PASLQLGA-VSPGALTSMGPANAPPQHL 115

  Fly  3538 -DDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTP 3601
             .....:|...|.||.            |......:|.|             ..:|.::|.....
Zfish   116 RQSSYEIPDDMPLPPG------------WEMAKTPSGQR-------------YFLNHNDQTTTWQ 155

  Fly  3602 ESSESTSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGA------SGTTATITDMSP 3660
            :..::.....||..|.|.|::....::.:.| ..|...|:|.::.|.      ...|.:..|...
Zfish   156 DPRKALLQMNQAAPASPVPVQQQNIMNPASG-PLPDGWEQAITSEGEIYYINHKNKTTSWLDPRL 219

  Fly  3661 EVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEH--LRMQRIRQRAQQNAIQIAHDSLVEVNPE 3723
            :.|.|:....:.:.......:.|||..:..|:..:  :|:|:|....::..|:   ..|:...|:
Zfish   220 DPRFAMNQQRISQSAPVKQGSQLPSSPQSGVMSGNNPIRLQQIHIEKERLRIK---QELLRQRPQ 281

  Fly  3724 FLA---ALPLNIQSEVLMQQRIEQ----QRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEE 3781
            .||   .||.:::.:...|..:..    |.....|.|..||...:..:.:..|:....:  .|..
Zfish   282 ELALRNQLPTSMEQDGGTQNPVSSPGMGQDARNMTTNSSDPFLNSGTYHSRDESTDSGL--SMSS 344

  Fly  3782 SQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQSLDDT 3832
            ..:...|.:      ||....|...|..:.....:...|||...|.::..|
Zfish   345 YSVPRTPDD------FLNSVDEMETGDTLGPGSMATQPSRFPDYLDAIPGT 389

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 13/81 (16%)
DUF4414 3675..3779 CDD:291075 21/112 (19%)
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
yap1NP_001132952.1 FAM181 <41..186 CDD:291891 33/175 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..89 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 97..116 5/18 (28%)
WW 127..158 CDD:197736 8/55 (15%)
WW 188..217 CDD:278809 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..254 4/23 (17%)
Transactivation domain. /evidence=ECO:0000250|UniProtKB:P46937 247..442 29/154 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 286..374 15/95 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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