DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and nedd4l

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_021324687.1 Gene:nedd4l / 559634 ZFINID:ZDB-GENE-051118-2 Length:1279 Species:Danio rerio


Alignment Length:715 Identity:234/715 - (32%)
Similarity:343/715 - (47%) Gaps:153/715 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  4529 SSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKS-TKPTLSQILC 4592
            ||.|..|.:....||.|.:::|..:         ..|::..||.:....|||.: |.|.|..   
Zfish   619 SSSMTDGVSDQAQPPTPTQSSQTRR---------TRAQTVTGVEDTMSPSASYALTTPGLPP--- 671

  Fly  4593 LDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAA 4657
                         ..||.||        |....:::   :|...|....|..:......|  |:.
Zfish   672 -------------GWEERKD--------PKGRTYYV---NHNNRSTTWTRPILQQHTEDG--AST 710

  Fly  4658 GAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFD-DEPRMQ----------------DASTN 4705
            ...|:||..||.|             .|:|||::|.. .||:::                :.:.|
Zfish   711 SVAAVGGATAATP-------------PASTPSTSSGHLSEPQVRRPRSLSSPTVTLSSPLEGANN 762

  Fly  4706 TPL-------VTNPST------STAMSAHEA---------QLR---QDRQKFLQFAEKHRTVLNQ 4745
            .|:       .:||.:      |:..:.|:|         ::|   ..|..|:....:..|..:.
Zfish   763 VPIRRAVKDTFSNPQSPQPSPYSSPKTQHKANQSFLPPGWEMRIAPNGRPFFIDHNSRTTTWEDP 827

  Fly  4746 ILRQSPTHLSD---------GPFAVL------------------VDHTR---------------- 4767
            .|:. |.|:..         ||...|                  :||..                
Zfish   828 RLKY-PVHMRTKASLDPGDLGPLPNLPEEPGWEERVHADGRTFYIDHNNKKTQWEDPRLQSPAIT 891

  Fly  4768 ------ILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRL-GPEEWKNRFYI 4825
                  ..:|..|..||:.:|::..:...|.|  :.:.|..:||:|:|.:..| .|:..|.|.:|
Zfish   892 GPAVPYSREFKQKYDYFRKKLKKPADIPNRFE--MKLHRNNIFEESYRRIMSLKRPDSLKARLWI 954

  Fly  4826 VFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSH-ANPNHLSYFKFVGR 4889
            .||.|:|.|.||:.|||:.::|:|:|||.|.||..|..|..|..|||:|. .|.:|||||||:||
Zfish   955 EFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGR 1019

  Fly  4890 VIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTE 4954
            |...||:..|||:.:|.|.|||.:||||:...||||.|.|:|..|.::::||.:.|  :|.|..:
Zfish  1020 VAGMAVYHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL--DLRFCID 1082

  Fly  4955 VQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIF 5019
            ...||.|...||||:|.|..||.:||.||:.||.|.:....:::|::||||||.::||..||.||
Zfish  1083 EDNFGQTYQVDLKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIF 1147

  Fly  5020 NEQELELLISGLPDIDIEDLKANTEY-HKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKV 5083
            :|.|||||:.||.|:|:.|.:.:|.| :.|......|||||:|:...|...|.:.||||||||:|
Zfish  1148 DENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 1212

  Fly  5084 PLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            |:.||..|.|.||.|.|.|.:.. :.|:||.||||||:||||||::::.||..||.|: |.::||
Zfish  1213 PMNGFAELYGSNGPQLFTIEQWG-TPDKLPRAHTCFNRLDLPMYETFEDLREKLLMAV-ENAQGF 1275

  Fly  5149  5148
            Zfish  1276  1275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 168/356 (47%)
HECTc 4820..5148 CDD:214523 159/329 (48%)
nedd4lXP_021324687.1 C2 <374..430 CDD:326325
WW 473..499 CDD:306827
WW 669..698 CDD:306827 8/55 (15%)
WW 798..829 CDD:197736 4/30 (13%)
WW 856..885 CDD:238122 2/28 (7%)
HECTc 946..1275 CDD:214523 159/332 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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