DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and WWC3

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens

Alignment Length:	1011	Identity:	189/1011 - (18%)
Similarity:	324/1011 - (32%)	Gaps:	314/1011 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1690 DAMVSLVKLLDCMSQWMLEQSTETNTGQQRATVPRWVQNLVDLIDAIDSISHILQRK-------- 1746
            |.:..|.::.|...||..||.....            :.|:...:|:::...|.|.|
Human     2 DHINKLTQIEDPREQWRREQERMLK------------EYLIVAQEALNAKKEIYQIKQQRFELAQ 54

  Fly  1747 ---ANMRAVSSDVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLYINIGRQRCTVSLNCMTQV 1808
               ..:..:..|..|.|.:|...::..::.:...|: |..|..|.....:.|:        :||:
Human    55 EEYQQLHKMCEDDSRSYASSFSGYSTNTKYDPHQIK-AEIASRRDRLSRLKRE--------LTQM 110

  Fly  1809 -SEASGTHRPVCPALKLSEAITSLNNPVALHKVEHILNRVVRTAPDGSGTVHSDELISLRQLVNF 1872
             .|.....:.|....::...::|.:....|.:.:.|::. :||......|...:....:..|...
Human   111 KQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSE-LRTIKKAICTGEKERRDLMHSLAKL 174

  Fly  1873 TDGQQPQQSENSANPSEEATSEDGP----AAANSGSPPATMTTRSKT--------RQKSAAAAAA 1925
            ||     ..:||.:.::...  |.|    ...::|.|.......|:|        ..|:......
Human   175 TD-----SFKNSCSVTDSLV--DFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRV 232

  Fly  1926 AKNKSQSGGSPPIPKRTQKI--ILNEEQVGLSKFDCGRIIGSIVDLLQPSHQMLNETKLSLLRL- 1987
            ..|.........:....|::  :.||.....::.|..|:     .|::....:|.|.:|.:.:.
Human   233 RLNWQYEEARKRVANIQQQLARLDNESWPSTAEADRDRL-----QLIKEKEALLQELQLIIAQRR 292

  Fly  1988 ----CARLTRNYDNAQVFIRRGGV--------RMLLHLQQACSFMGFPTYANIILRHVLEAPPVL 2040
                .|||....:..:..:||...        |:||..::.|           :|..:.||..:.
Human   293 SAGDVARLEEERERLEEELRRARATSAQGATERILLQEKRNC-----------LLMQLEEATRLT 346

  Fly  2041 QEAMERVLGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEML---KGEYLINTNSTTL 2102
            .....::..:.|:.:.             |||..||..   :|:::..|   :|    :.:|.:.
Human   347 SYLQSQLKSLCASTLT-------------VSSGSSRGS---LASSRGSLASSRG----SLSSVSF 391

  Fly  2103 AD----------DARVMVKSKFGQQPTAAAGGATPHNQTPTPPPAAKDELK-DDPQVQSSVAVLK 2156
            .|          ||......:|...|..:.|...|.::.|.|....|.... |.||..:|::...
Human   392 TDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLASLSSRS 456

  Fly  2157 EL----------------------LHGLVQPCWHYGGTGSLDR------GQGAAEL-----LQPD 2188
            .|                      |..|...| ...|.|:|||      ..|..:|     |||.
Human   457 SLSSLSPPSSPLDTPFLPASRDSPLAQLADSC-EGPGLGALDRLRAHASAMGDEDLPGMAALQPH 520

  Fly  2189 QPPGTAQGCHDDELYFRFQETPAPVSSKKQSSSGGGAAAAGQTGQATEKFEPCCCTWHIPTSGHT 2253
            ..||..:|.|        :..|.|.|:                                |..|
Human   521 GVPGDGEGPH--------ERGPPPASA--------------------------------PVGG-- 543

  Fly  2254 HAKPTISRATLLKLLADSTRAYQSLVPRV--LLSHVYTPADSPLISAPQQTFLGVLLDRFLPITQ 2316
                |::      |..||.:..:....|:  .||.....:||           ||    |.|:|:
Human   544 ----TVT------LREDSAKRLERRARRISACLSDYSLASDS-----------GV----FEPLTK 583

  Fly  2317 RHHVPEVSTM------------TRVLICSLSDCYQQPGVQVHVAEELHAAVARALAQPDSAEKHT 2369
            |:...|....            ..:|..|.|:|     :.|||.:..:.|   .||..:..:.|.
Human   584 RNEDAEEPAYGDTASNGDPQIHVGLLRDSGSEC-----LLVHVLQLKNPA---GLAVKEDCKVHI 640

  Fly  2370 R--LQVLMSLFPNLIESPMLYDKVHMHRNNMYRVLLRQGVMTY-----------------LTKVA 2415
            |  |..|.|..||...|..|..:|.:..|.::|:.:....:|.                 |..:|
Human   641 RVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIA 705

  Fly  2416 QYKDLSNHNTLSTLAAILRPMEILLRF-SVSTTTLGSKRILFGSGGPGGPNASGNGNNTAGGSSG 2479
            |. :|:::::||         |:.||: ||.         :|.|..|.....:|    .||.||.
Human   706 QI-NLADYDSLS---------EMQLRWHSVQ---------VFTSSEPSRTREAG----CAGESSA 747

  Fly  2480 NGPG-----SGNTYGTIINRRLYPRLAARTGFGSAMERSNAMGGEHVLRDIIRNVLSDRRHAFEF 2539
            ..|.     ||.|....:      .||..|....|:||.                |::.|...|:
Human   748 RDPAHTISISGKTDAVTV------LLARTTAQLQAVERE----------------LAEERAKLEY 790

  Fly  2540 IFNSDDMAVDSEDAAAPGSGVGGGGSGAGSVGGGVS 2575
               :::..::.|........:......|.||..|.|
Human   791 ---TEEEVLEMERKEEQAEAISERSWQADSVDSGCS 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922	12/72 (17%)
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	23/135 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		12/65 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		13/79 (16%)
		C2_Kibra	602..725	CDD:176062	32/140 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900