DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and herc4

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_005173092.1 Gene:herc4 / 557513 ZFINID:ZDB-GENE-070801-1 Length:1052 Species:Danio rerio


Alignment Length:758 Identity:171/758 - (22%)
Similarity:290/758 - (38%) Gaps:167/758 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  4463 PSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTG-GGVACGAGDNDDDIIDIEGDGGASG 4526
            |.:...::..:.|.|.|.|..|          |..|:.| |.:.....|..|.:.          
Zfish   387 PPLDVRITRPAGQIYTLSTELI----------QKWLNHGLGRIPAEITDEIDLVF---------- 431

  Fly  4527 GSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEAR---------SFPGVGNHAVASASKS 4582
             ||:....||..:.|.|....|:.....     .|.:.||         ..|.:.....||..|:
Zfish   432 -SSASCLNGSFLSSSNPDHYSTSSKCSG-----VDINTARLLFHKLIQTDHPQISQIIAASLEKN 490

  Fly  4583 TKPTLS----QILCLDVLWNTLSEC-------------------LVALEESK--------DEFAV 4616
            ..|.||    .|..|. |:.||.||                   :|:|:::.        ..|..
Zfish   491 LLPKLSSSPPDIEALR-LYLTLPECPLLCNPNNFTTLTIPFAKAIVSLKDAPIKVLGNWWSRFEP 554

  Fly  4617 LVLQPTVEAF-----FLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYS 4676
            :|.|..||.:     :|:.....|......|.|    ..|...:......:..:...|....:|.
Zfish   555 VVFQRLVELYKEVVVYLLRMQKLGIPLSEQRIF----TCFLDTSLKLLEILHSVNERAGQIIQYD 615

  Fly  4677 PF----MDDVSSANTPSSASFDDE--PRMQDASTNT---PLVTNPSTSTAMSAHEAQLRQDRQKF 4732
            .|    :|::.......:..|..:  ..:.|:....   |.|.:....||:...:|.::      
Zfish   616 KFYIHELDELIDIRNDYATWFQQQMFSVVMDSQVTLCKYPFVFDAQAKTALLQTDAVIQ------ 674

  Fly  4733 LQFAEKHRTVLNQILRQSPTHL--------SDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGI 4789
            :|.|      ::|..||:.|.|        |..|..:|:                          
Zfish   675 MQMA------VDQAQRQNFTSLFLSGGGVESVNPCLILI-------------------------- 707

  Fly  4790 RREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPM 4854
                    |||..|..||..||.:....::|....::|..||..||||:.:|::::|.:|:.:|.
Zfish   708 --------VRRENVVGDSMEVLRKSKNVDYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELLHPK 764

  Fly  4855 YALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVK 4919
            |.:|......|:.:....:.    ..:..|..:|.|...|:::..::|..|..:.||.:|.|...
Zfish   765 YGMFRFHEESRLIWFACKTF----EDIDLFHLIGVVCGLAIYNLTIVELNFPLALYKKLLKKTPT 825

  Fly  4920 HTDMESQDYEFYKGLDYLM---KNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKF 4981
            ..|::....:..:.|..|:   ::|:... :.|.|:.....||.|::.:|.|||.|.:|.:.|:.
Zfish   826 LEDLKELMPDVGRSLQQLLDYTEDDLEET-FCLNFTITEDNFGATEVVELIPNGTDISVNKSNRQ 889

  Fly  4982 EYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYH 5046
            |:|........:.|:..|..||..||:.:....::.:|...||:.::.|..:.|.::|:.:|||.
Zfish   890 EFVNAYVDYIFNKSVAPQFSAFYAGFHKVCGGKVLELFQPSELQAMVIGNTNYDWKELEKSTEYK 954

  Fly  5047 -KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSL-----EGMNGIQKFQIHRD 5105
             :|.:....|:.||..........:.:||.|:||:.::|:.|..||     ....|.|.|     
Zfish   955 GEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLALVIQPTAGGEQYF----- 1014

  Fly  5106 DRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
                   |.||||||.||||.|.|.:.::..||.|| |.::||
Zfish  1015 -------PVAHTCFNLLDLPKYTSKNTMQEKLLHAI-EHNQGF 1049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 102/362 (28%)
HECTc 4820..5148 CDD:214523 92/336 (27%)
herc4XP_005173092.1 RCC1 3..49 CDD:278826
RCC1 52..99 CDD:278826
RCC1 102..152 CDD:278826
RCC1 156..205 CDD:278826
RCC1 208..257 CDD:278826
RCC1 260..308 CDD:278826
RCC1 313..377 CDD:278826
HECTc 704..1049 CDD:238033 101/396 (26%)
HECTc 730..1049 CDD:214523 92/336 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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