DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and LOC556872

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_021334149.1	Gene:	LOC556872 / 556872	-ID:	-	Length:	1472	Species:	Danio rerio

Alignment Length:	1602	Identity:	306/1602 - (19%)
Similarity:	471/1602 - (29%)	Gaps:	560/1602 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2998 AIASAALRPSSGSWMAPDFNFIRISGGDSSMGSG---------------PAIGGNANGGDMNVFI 3047
            |:.....:|..|.....|:||:.:....|...||               .::.||..|....|.|
Zfish   129 AVPCTTRQPRDGEISGVDYNFVSVEEFFSLEESGALLESGKFKEKKNGFESLEGNYYGTPRPVHI 193

  Fly  3048 TP----------------------SMS-LERAGGAPGSGQTMSELLNEQPTGAGGGGGGGS---- 3085
            .|                      |:| ||:||....:        :|:.:|..||..|.|
Zfish   194 GPDSPPISYQEHRNLLRNFRTRSKSLSNLEKAGEEGDN--------SEEDSGLSGGSAGASSVPV 250

  Fly  3086 --ASGVGGVGANGGTTGQHPNATLCTNGVRRR------LLYLDQQYCVCMPTHQNPTEETQMETF 3142
              :|........||.|....|......|.|.|      ::|.|.........|..|:..:
Zfish   251 HTSSPSQSRNLRGGNTSALENGLGPRRGARVRGSENWEMMYSDSGNAYYKDHHLKPSSSS----- 310

  Fly  3143 TQDALHWWLEEATLLDMESQTDACL--YAAHFLLPHLIKELKAAHQQRKQEEAARQSTTPASGSN 3205
                   ||....    .|:.:.|:  |.:|..:...:.:|     |.:..:.|..:..|   |.
Zfish   311 -------WLNRRA----HSRDNVCMPEYISHSCIWQSLTDL-----QSQCVQVAEFTDQP---SE 356

  Fly  3206 ASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVPPVAASATGGTRRSSIPVLISS 3270
            ....|..|..|.|          |.|...|.|                   ||:||.....:.|.
Zfish   357 LRGFSVHTRLVKG----------ARGFGFNIV-------------------GGSRRREFLQIYSI 392

  Fly  3271 TL-GPSSASSA--------TSATGN--------------GATSDATTTTGGPTRNFSSVDSNVS- 3311
            |. |||:.::|        |...|.              |.|.|.....|.|....|.....:|
Zfish   393 TPGGPSTLNTADILVYINDTCVLGYSHKDVVEMLKAIPIGHTVDIMVRRGYPMLYNSEGCPKMSN 457

  Fly  3312 -----SETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQD--SEGDRSTSTTTGTAADGAESQ 3369
                 |:.|:...||......:.|:.||   ||::.|.:...  ::.||.:|......|......
Zfish   458 PRLTASQNQSPHLPPPTTTQPQAQAPLP---YAQLHLNHNSPPWADFDRGSSRNLRVRASRFSLD 519

  Fly  3370 SQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHT 3434
            :..||...|:          ||.|  |||                            .|||:|:
Zfish   520 ANGNSPPFAS----------PPRP--PSS----------------------------YQGSNGY- 543

  Fly  3435 NSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPRPSANRTPAPTLVSMPTPMSNAALEQLNVT 3499
                                          ||.|.||.
Zfish   544 ------------------------------GSGFLRPP--------------------------- 551

  Fly  3500 APDVVRTDRNFALPSSLEV----DVDVLPGIVDLPQQEAQPEDDQLLLPPPP------------- 3547
                 ||.|:.....|.|:    |.:|:..|........:..::..|..|||
Zfish   552 -----RTARSIRRLQSAELASQSDSEVVSAIGSHRASFIRNHNNNSLSTPPPLRLHSFKSSESDL 611

  Fly  3548 ---PPPPSDTTPLVHAEDDLWPGTV--VSAGTREES--SAPAVATESTEAVNESNQPEPT---PE 3602
               .|||....||.|.|  |.||.|  ...|.|..|  ..|..:..:..:...|:.|..|   ..
Zfish   612 SSSTPPPISRLPLPHTE--LSPGPVSFSPGGGRRYSHLRKPQNSMLTPPSSVHSDGPYFTFNGTA 674

  Fly  3603 SSESTSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALG 3667
            |:.|.|||...||       || |:.|.:|             :|..|..|.    ...|..||.
Zfish   675 SASSGSPNSSIPS-------PG-ALSAVIG-------------SGVGGMAAG----GELVPVALA 714

  Fly  3668 DLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNI 3732
            ..|  .|.:..|..........:.:     ::::....|.|.:| :.|::|::|       ..::
Zfish   715 KCE--RGSNMGFSVTAGGHGGRQTL-----VKKVWDHRQCNGLQ-SGDAVVKIN-------GADV 764

  Fly  3733 QSEVLMQ-QRIEQQRQAAQTA------NPEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPE 3790
            ||....| |||.|:.......      .|.:       :.|.|.::|          ::...||.
Zfish   765 QSLSFAQVQRILQEHTKKGEVILLVYRGPSN-------YSNSPSSVR----------RLTPPPPR 812

  Fly  3791 LAAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQS------------LDDTRWHSSIWYDAS 3843
            .|::::....|  |...:|....|||.||.| .:.:||            |:...|.||  .|..
Zfish   813 SASDSEVPFTD--SMPLSRNSLTPPSPALVR-SSLVQSTSFLDSVPVTLTLEPRDWMSS--EDGG 872

  Fly  3844 GNAQP-----QHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLFVEDQK 3903
            ....|     :..|...:..........|..|....:...:.||:     ...:||...||..::
Zfish   873 TVLSPRVKTEEKEQPPALRGYEVELKRKPGEGFGFVIASQDVENV-----KAVSLLPHRFVTVRR 932

  Fly  3904 VNSM----------RLH----RVIRNLCHHEPTRDWIISALISIIQKT---------------NE 3939
            .:..          ||.    |.:.||.|.|         |..|:::.               :.
Zfish   933 GSPAARSGQIRPGDRLEAVDGRSVVNLPHRE---------LAQILRRAGNTLRLTIVPRASAHSS 988

  Fly  3940 DNANFGAGQAGGKPEWLKLRVDA-------------AFG--------YKSNIFLINRLYEGSARS 3983
            :.|::.......|....|.:.||             .||        |...::::. |.||...|
Zfish   989 ERADYDPDYKNRKTHKSKPKQDATRYYSVELERGPTGFGFSLRGGSEYNMGLYVLG-LMEGGPAS 1052

  Fly  3984 ISINPQAAQMIVR----------------------NCLDLLFVLAKHYPSSFVP-FNRDVKARRI 4025
            .|...|.:..:|.                      :.:.|:|.....|    || ::||     .
Zfish  1053 RSHKIQVSDQLVEINGDSAAGMTHSQAVEQIRTGGSRIHLVFKRGNGY----VPDYDRD-----H 1108

  Fly  4026 LSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVP--------------PGGTLDFRSRFCRYQV 4076
            ::||...|.|.. |...|.|........|.....|              .||..:..:|....:.
Zfish  1109 ITAVSSSPQPLQ-SNLAAVSHHRPQRDATSSLQKPEKTNRGWKEPRERSDGGDRESPARLKGDRQ 1172

  Fly  4077 VNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQ----NKHSVPYQTNAKNFW 4137
            ..|.||..|:......|:|    .:|.:..:.::....||...|.:    ||.||.....:|:..
Zfish  1173 GRRRRSRDDERRRRSYSLP----RNTPRRHSDESMKVEKVERNGREMEKGNKRSVDRPKRSKSEE 1233

  Fly  4138 DV---VLNIDQQTQVRLANVAQFPLTSQPAWEWQPN----------------------------T 4171
            .|   ....|:....:..|..:.|   ||..:|:.|                            .
Zfish  1234 RVRERKREGDESKNTQTINKHRLP---QPKLQWEENEEEEEEWDGETEQEWTRERERLKDKKRER 1295

  Fly  4172 ADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLL---------ASLSTELPKEEEL-----L 4222
            .:..|......|:|          .|.:.:.|.|::|         ..:|.||.:|::.     |
Zfish  1296 EEIASLDSESDGEL----------ESENESKMNVEVLEWETNKKTHQDISEELNREQDTSFHKRL 1350

  Fly  4223 PLSD--QMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQASPASGNPA 4285
            |...  .:||.....|::|....:.      .:|..:|....|.    .|....||:..|.....
Zfish  1351 PYLGIRVLPPDTQSRPLRRISGHSL------EEPVGKNEFNRTP----FAFLTTEQSDYAESESG 1405

  Fly  4286 SGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLV 4327
            :..|........:..|||.:     ..|..:.||:.||..|:
Zfish  1406 ASVSECSISAASISGLSVYM-----TERCHLNSKHNSQEPLL 1442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	19/80 (24%)
		DUF4414	3675..3779	CDD:291075	18/110 (16%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
LOC556872	XP_021334149.1	PDZ_signaling	24..88	CDD:238492
		NK	111..>190	CDD:327404	12/60 (20%)
		PDZ_signaling	365..440	CDD:238492	21/103 (20%)
		PDZ	722..791	CDD:238080	14/81 (17%)
		PDZ_signaling	893..980	CDD:238492	17/100 (17%)
		PDZ_signaling	1017..1093	CDD:238492	10/76 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900