DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and Magix

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_061302.2	Gene:	Magix / 54634	MGIID:	1859644	Length:	324	Species:	Mus musculus

Alignment Length:	362	Identity:	75/362 - (20%)
Similarity:	106/362 - (29%)	Gaps:	129/362 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  3181 LKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSS 3245
            |:.:...|.::...|....|.    |:..::..|::|..|..|.......|:      :|..|:.
Mouse    20 LQGSRSPRARQLLERLDARPL----AARAAADLTALVRKAGATLRLRHTEGV------SGLDSAD 74

  Fly  3246 LVV--------------PPVAASATGGTRRSSIPVLISSTLGPSSASSATSATG-------NGAT 3289
            :.|              |....|.|.||....:||..:..   |.|.....|||       .|..
Mouse    75 IEVTDSRLPHATLVKHRPQHQRSETLGTWTEPLPVTQNKA---SYALKVPQATGRFSVELTRGPA 136

  Fly  3290 SDATTTTGGPTRNFSSVDSNVSSETQTTTR-----PPRQRGGLRQQSQLPFNIYAEIDLTNEQDS 3349
            ....|.:||         .|||.:...|..     .|.||.|..|...|...|       |.|.:
Mouse   137 GFGLTLSGG---------RNVSGDAPLTVHGLLKDGPAQRCGRLQAGDLVLYI-------NGQST 185

  Fly  3350 EGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELL 3414
            :|                        .|.|||          |..:.:.|    ||.      .|
Mouse   186 QG------------------------LTHAQV----------VERIRTGG----PHL------CL 206

  Fly  3415 LLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNR--DLPACLQRHDHPAGSIFPRPS----- 3472
            :||.......:|::...||..:.|:     ::.|.:|  ........|..|.....||||
Mouse   207 VLQRPQDMDGSRIKEVGGHRKTDRS-----LDPRGSRVESRSTISPVHHRPKTRTSPRPSPEAVA 266

  Fly  3473 ---------------ANR---TPAPTLVSMPTPMSNA 3491
                           .||   ||.|.||.....:|.|
Mouse   267 IGHVVRAVEHPTEDLENRIPGTPGPWLVPSEDRLSRA 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
Magix	NP_061302.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/5 (20%)
		PDZ	126..211	CDD:214570	29/144 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..263		12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900