DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	608	Identity:	112/608 - (18%)
Similarity:	187/608 - (30%)	Gaps:	173/608 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  3319 RPPRQRGGLRQQSQLPFNIYA----------------EIDLTNEQDSEGDRSTSTTTGTAADGAE 3367
            ||...:..|||:|::  ::|.                |:|:    |::..|.........|...:
Human   700 RPQLYQQFLRQKSKI--SLYCLSQDEGRGTLYKYRPEEVDI----DAKLSRLCEQDKVVHALEEK 758

  Fly  3368 SQSQHNSSSTAAQVAVPQHQR---HPPVP----------------LLPSSGRPSRPHTRLDET-- 3411
            .|..|....|..|..:...|.   |...|                ||.:....||....|:..
Human   759 LQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWR 823

  Fly  3412 ELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNR------DLPACLQRHDHPAGSIFPR 3470
            |...|:......||::|....|....:|..:.:..|:..:      |:...|.:|....|:
Human   824 EYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGT---- 884

  Fly  3471 PSANRTPAPTLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQ 3535
                 |....:.|.|........|:..|..|.                  ..||...|..:|
Human   885 -----TEIGMIGSKPFSTVKYKNEEEEVVPPR------------------PPLPRSYDFTEQ--- 923

  Fly  3536 PEDDQLLLPPPPPPPPSDTTPL-------VH----------------------------AEDDLW 3565
                    ||..||.|||::.|       ||                            :|.:|.
Human   924 --------PPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELT 980

  Fly  3566 PGTVVSAGTREESSAPAVATESTEAVNESNQP---------EPTPESSESTSPNPQAPSAEPTPL 3621
            ....|.....||.|.| |:...|..|..|:.|         .||||||...|......:.:...|
Human   981 TVAEVDESNGEEKSEP-VSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDL 1044

  Fly  3622 EPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEVR----AALGD----LEVPEGVDPS 3678
            .          .:.|.:..|....|.::....|:.:....:|    |.|.:    |.|....|.|
Human  1045 R----------TERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQS 1099

  Fly  3679 FLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIE 3743
            .|.: ||.:|:    ...|..:.|:|..:.......::  :|.|:........:|.:....|.::
Human  1100 PLQS-PSNLRD----NPFRTTQTRRRDDKELDTAIREN--DVKPDHETPATEIVQLKETEPQNVD 1157

  Fly  3744 QQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGA 3808
            ..::..:|.|    :.....|:..|..:....:.|.|.::     .::..:..|..:|.......
Human  1158 FSKELKKTEN----ISYEMLFEPEPNGVNSVEMMDKERNK-----DKMPEDVTFSPQDETQTANH 1213

  Fly  3809 RMDAHPPSNALSRFQTTLQSLDD 3831
            :.:.||..|       |..|:|:
Human  1214 KPEEHPEEN-------TKNSVDE 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	20/84 (24%)
		DUF4414	3675..3779	CDD:291075	17/103 (17%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809
		WW	58..87	CDD:278809
		PH_PEPP1_2_3	164..267	CDD:270068
		PH	170..266	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900