DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and HERC5

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_057407.2 Gene:HERC5 / 51191 HGNCID:24368 Length:1024 Species:Homo sapiens


Alignment Length:531 Identity:120/531 - (22%)
Similarity:209/531 - (39%) Gaps:75/531 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  4677 PFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSA----HEAQLRQDRQKFLQFAE 4737
            ||...|...:..||...::.......||.:.||....|:.....    ..|:...:.|..|:..:
Human   511 PFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQLDYWDESAEENGNVQALLEMLK 575

  Fly  4738 K-HRTVLNQILRQSPTHL--------------------------------------SDGPF---- 4759
            | ||  :||:..|.|..:                                      |..||    
Human   576 KLHR--VNQVKCQLPESIFQVDELLHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNN 638

  Fly  4760 --AVLVDHT-RILDFDVK--RKYFQT---ELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGP 4816
              .:.:.|| .:|..:.|  :.|.::   |.||..|...|....::|||..:.||....|.:...
Human   639 LSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFEN 703

  Fly  4817 EEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPG-DRVTYMINPSSHANPNH 4880
            |:.:...::.|..|.|.|.||:.:|::..:..|:..|.|.:|....| ..:.:.:.|.....   
Human   704 EDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKK--- 765

  Fly  4881 LSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTL 4945
             .|| |.|.:...::.:..:....|..:.:|.:|.:.....|::....:..|.|..|:.::..  
Human   766 -RYF-FFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGD-- 826

  Fly  4946 GYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDI 5010
            .:|..|.............:|.|||....|.:.||.:||........:.|::...:.|..|||.:
Human   827 NFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKM 891

  Fly  5011 IPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHK-YTSKSAQIQWFWRALRSFDQADRAKFL 5074
            ..:.:|.:|:.:||:.:|.|..|.|.:..:.|..|.. |.|....|..||:|.......::.|||
Human   892 CDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFL 956

  Fly  5075 QFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPC-AHTCFNQLDLPMYKSYDKLRSCLL 5138
            .|:|||.::.::...::       |......:...:|.|. |.|||:.|.||.|.:.:.:...|.
Human   957 VFLTGTDRLQMKDLNNM-------KITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQ 1014

  Fly  5139 KAIHECSEGFG 5149
            :||:. :.|||
Human  1015 EAINN-NRGFG 1024

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 85/355 (24%)
HERC5NP_057407.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
RCC1 1 96..155
ATS1 <140..346 CDD:444065
RCC1 2 156..208
RCC1 3 209..260
RCC1 4 262..312
RCC1 5 314..364
HECTc 681..1024 CDD:238033 85/357 (24%)
Blue background indicates that the domain is not in the aligned region.

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