DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and HERC5

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_011530324.2 Gene:HERC5 / 51191 HGNCID:24368 Length:1100 Species:Homo sapiens


Alignment Length:1150 Identity:232/1150 - (20%)
Similarity:381/1150 - (33%) Gaps:311/1150 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  4236 PVQRAGAAAAAAHPPPPQ-------PPAENTA-------------TATEIGDGLAANIEEQASPA 4280
            |:...|...:.||.|.||       |||::.:             |.|.|  .....:|.||.|.
Human    26 PLPARGHFLSPAHRPLPQPTTCCLWPPAKSLSLQFPFPFRFRPLKTTTNI--MFRFPLELQAPPP 88

  Fly  4281 SG-----NPASGD-------SNAGAKRTQLPTLSVALP-----VTPSKPRRKIYSKNFSQLQLVI 4328
            :.     .|..|.       ....|.|:..|..| |.|     ::|...|..:........:..:
Human    89 NSTWGAWRPGRGSVAEAAVPRRHAAARSWFPLCS-ATPEAVGALSPGTRRSLLSPLGLGPRKAAM 152

  Fly  4329 EVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAIL--GLAEEVRQAIQMLLNEIRMY 4391
            |..:.:.....|.....|...  ||.:::..|....:.:||.|  .|...|....|:..:..|:.
Human   153 ERRSRRKSRRNGRSTAGKAAA--TQPAKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSPGRLA 215

  Fly  4392 NIHQGGAGT-TSQAASTSGAAAATASYVPTVSGASLLPNLAVH---EGIMQDRFTAEHVIISAPK 4452
            .:.:||||. ..|..:.||.|.       |.....|..|:.:|   :|       |||::|.: .
Human   216 VLERGGAGVQVHQLLAGSGGAR-------TPKCIKLGKNMKIHSVDQG-------AEHMLILS-S 265

  Fly  4453 NAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIID 4517
            :.|| .|....|||.|...|     .|:..||.......|.:. .||.||.:... |.|      
Human   266 DGKP-FEYDNYSMKHLRFES-----ILQEKKIIQITCGDYHSL-ALSKGGELFAW-GQN------ 316

  Fly  4518 IEGDGGA------------------------SGGSSSDMAPGSASTISPPPPMETNQIAQDGDDD 4558
            :.|..|.                        |.|.:..||...:..|.   ....|:..|.|...
Human   317 LHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIY---SWGKNECGQLGLGH 378

  Fly  4559 EEDDDEARSFPGVGNHAV----ASASKSTKPTLSQILCL-----------DVLWNTLSECLVALE 4608
            .|..|:.....|:.|..|    ...|.|...|...:|..           :...|.|..|||   
Human   379 TESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLV--- 440

  Fly  4609 ESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGR-SFMPNAAGFGLRAAAGAGAIGGLGAAAPSA 4672
                  |.||             .:|......|| ..:...:..|...:.|:|..|.||... :.
Human   441 ------AELV-------------GYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG-TR 485

  Fly  4673 QEYSPFMDDVSSANTPSSASFDDEPRM----------------QDASTN----TPLVTNPSTSTA 4717
            .:..|....|||:......|...|..:                :::..|    .|.:...:....
Human   486 DQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTVKRW 550

  Fly  4718 MSAHEAQLRQDRQKFLQ------------FAEKHRTV--------LNQ----------------- 4745
            ::..|.:..|..::.:|            |..|.||.        ||:                 
Human   551 IADVETKRWQSTKREIQEIFSSPACLTGSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNM 615

  Fly  4746 --------ILRQSP--------------------THLSDG------PFAVLV----DHTRI---- 4768
                    :|::.|                    .|:|:.      |||.:|    |.:.:    
Human   616 ITTCLKDNLLKRLPFHSPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEE 680

  Fly  4769 ------------------------LDF---------------DVKRKYFQT------------EL 4782
                                    ||:               ::.:|..::            |.
Human   681 YWATLQESTFSKLVQMFKTAVICQLDYWDESAEENGNVQALLEMLKKLHRSKKHKAYLRSAAIEE 745

  Fly  4783 ERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIIS 4847
            ||..|...|....::|||..:.||....|.:...|:.:...::.|..|.|.|.||:.:|::..:.
Human   746 ERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLF 810

  Fly  4848 REIFNPMYALFCVSPG-DRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYK 4911
            .|:..|.|.:|....| ..:.:.:.|.....    .|| |.|.:...::.:..:....|..:.:|
Human   811 AEMIQPEYGMFMYPEGASCMWFPVKPKFEKK----RYF-FFGVLCGLSLFNCNVANLPFPLALFK 870

  Fly  4912 HILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVT 4976
            .:|.:.....|::....:..|.|..|:.::..  .:|..|.............:|.|||....|.
Human   871 KLLDQMPSLEDLKELSPDLGKNLQTLLDDEGD--NFEEVFYIHFNVHWDRNDTNLIPNGSSITVN 933

  Fly  4977 EENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKA 5041
            :.||.:||........:.|::...:.|..|||.:..:.:|.:|:.:||:.:|.|..|.|.:..:.
Human   934 QTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEK 998

  Fly  5042 NTEYHK-YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRD 5105
            |..|.. |.|....|..||:|.......::.|||.|:|||.::.::...::       |......
Human   999 NARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNM-------KITFCCP 1056

  Fly  5106 DRSTDRLPC-AHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            :...:|.|. |.|||:.|.||.|.:.:.:...|.:||:. :.|||
Human  1057 ESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINN-NRGFG 1100

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 85/355 (24%)
HECTc 4820..5148 CDD:214523 77/330 (23%)
HERC5XP_011530324.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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