DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and ASCC1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001185728.1	Gene:	ASCC1 / 51008	HGNCID:	24268	Length:	400	Species:	Homo sapiens

Alignment Length:	308	Identity:	58/308 - (18%)
Similarity:	107/308 - (34%)	Gaps:	76/308 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   900 STPRTQQAGGVVGSGAGATGTPAAASQAVKVVTPPEREAIP---LIDYILNVMKFIEAIFSNSPN 961
            |.|:..|.|.:|.:|....|..:|.:: :.|:....|...|   .:.:.||.::..|...
Human   121 SIPKPGQDGEIVITGQHRNGVISARTR-IDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFL----- 179

  Fly   962 GDHCREFVL------HGGLKPILQLLSLPNLPVDSPVSTTSQAVANVCKAILSQAQETKVLDVA- 1019
              ..:|.||      ||....|.|.....:|.:...|..:.:.:...|: :|.|.:|..:.|::
Human   180 --RFQEEVLAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCE-MLQQCKEEFINDISG 241

  Fly  1020 ----------LKQLADIVAQLKPLIKHFTFPGGSVLLAELVCCQRLEDGFANAEYTPILHNMSFV 1074
                      ::.:.|....:..|........||..|.|||  .|:.:.|.             .
Human   242 GKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGSNRLQELV--DRVLERFQ-------------A 291

  Fly  1075 HGYVVMLVHLCRNASNDMRTILLK------RWGVNRETGVQLLQQLVQLYISLVWESTILL---- 1129
            .|.:|...:..:..:..|.|:..|      |:.:....|..:.::........:.:|..||
Human   292 SGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNILKSFALLPRLE 356

  Fly  1130 ---------NLC----SDEPTQHPDLIWDEIAAQMSAAAGTADPLTEA 1164
                     |||    ||.|..         |:|::...|.:|..:::
Human   357 YNDAISAHCNLCLPGSSDSPAS---------ASQVAGITGVSDAYSQS 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642	22/97 (23%)
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
ASCC1	NP_001185728.1	Required for interaction with ASCC3. /evidence=ECO:0000269\|PubMed:29997253	1..53
		vigilin_like_KH	99..148	CDD:239087	8/27 (30%)
		PLN00108	157..370	CDD:177724	41/235 (17%)
		AKAP7_NLS	161..349	CDD:287446	34/210 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900