DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and Magi2

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_006535806.1 Gene:Magi2 / 50791 MGIID:1354953 Length:1414 Species:Mus musculus


Alignment Length:1279 Identity:233/1279 - (18%)
Similarity:376/1279 - (29%) Gaps:493/1279 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  3117 LYLDQQYCVCMPTHQNP---------TEETQMETFTQDALHWWLEEATLLD-------------- 3158
            |||....|...|..:..         |.|..||.....||   ||..|..|              
Mouse   133 LYLRTVPCTTRPHKEGEVPGVDYIFITVEEFMELEKSGAL---LESGTYEDNYYGTPKPPAEPAP 194

  Fly  3159 MESQTDACLYAAHFLLPHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPT 3223
            :.:.||..|..|          ..:|..:||:              |.|.|:....|:.......
Mouse   195 LLNVTDQILPGA----------TPSAEGKRKR--------------NKSVTNMEKASIEPPEEEE 235

  Fly  3224 ATSSIASGLLANAVSAGSGSSSLVVPP-------VAASATGGTRRSSIPVLISSTLGPSSASSAT 3281
            ....:.:|            :.:|:.|       .:|.|:|.|.....|..:.|.  |.......
Mouse   236 EERPVVNG------------NGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQ--PEELKDQM 286

  Fly  3282 SATGNGATSDATTTTGGPTRNFSSVDSN------------------VSSETQTTT---------- 3318
            ..|             .||:...:.||:                  :...|:||:          
Mouse   287 DDT-------------KPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKA 338

  Fly  3319 RPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGT-AADGAESQSQHNSSSTAAQVA 3382
            :||.:    .::::||:. :.:||             ....|| ..|....::|..:....|:..
Mouse   339 KPPEE----CKENELPYG-WEKID-------------DPIYGTYYVDHINRRTQFENPVLEAKRK 385

  Fly  3383 VPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINA 3447
            :.||               :.|||.|....|......::.:..|        ::|:..|:.|...
Mouse   386 LQQH---------------NMPHTELGAKPLQAPGFREKPLFTR--------DASQLKGTFLSTT 427

  Fly  3448 --RPNRDLPACLQRHDHP-----AGSIFPRPSANRTPAPTLVSMPTPMSNAALEQLNV---TAPD 3502
              :.|......:...|.|     ..|:.|     ..||.....|.|......:.::.|   |..|
Mouse   428 LKKSNMGFGFTIIGGDEPDEFLQVKSVIP-----DGPAAQDGKMETGDVIVYINEVCVLGHTHAD 487

  Fly  3503 VVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPP------PPPPPSDTTPLVHAE 3561
            ||:..::..:..|:.:   ||.....||   ..|||....:.||      |||            
Mouse   488 VVKLFQSVPIGQSVNL---VLCRGYPLP---FDPEDPANSMVPPLAIMERPPP------------ 534

  Fly  3562 DDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAA 3626
                  .:|:.....|:....::..|....:.:::|   |.|..|...:.|.....|.|:.....
Mouse   535 ------VMVNGRHNYETYLEYISRTSQSVPDITDRP---PHSLHSMPADGQLDGTYPPPVHDDNV 590

  Fly  3627 VDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEV 3691
            ..||.|| |.|.........||.|...||.| ||..:.....|::         ...|.....::
Mouse   591 SMASSGA-TQAELMTLTIVKGAQGFGFTIAD-SPTGQRVKQILDI---------QGCPGLCEGDL 644

  Fly  3692 IQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVL---------------MQQR 3741
            |.|         ..|||...::|..:|::    |...|:..::.::               |..|
Mouse   645 IVE---------INQQNVQNLSHTEVVDI----LKDCPVGSETSLIIHRGGFFSPWKTPKPMMDR 696

  Fly  3742 IEQQRQAAQTANPEDPVDTAAFFQNL--PENLRQAILTDMEESQIASLPP--ELAAEAQFL---R 3799
            .|.|      .:|:..:...|..|||  |..|.::...|..|:.....|.  ||..:::.:   |
Mouse   697 WENQ------GSPQTSLSAPAVPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESR 755

  Fly  3800 RDWESRNGARMDAHPPSNALSRFQTTLQSLDD--TRWHSSIWYDASGNAQPQHHQHTTIVHQHPH 3862
            :....|...|||:..|.         .:.||.  .|..|...:...|..:|              
Mouse   756 QQVPPRTSFRMDSSGPD---------YKELDVHLRRMESGFGFRILGGDEP-------------- 797

  Fly  3863 AHHAPNMGKPL---ALLMM--EDENILLDP-DSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEP 3921
                   |:|:   |::.|  .|.:..|.| |.|      ::|:...| :.:.||.:.:|.||  
Mouse   798 -------GQPILIGAVIAMGSADRDGRLHPGDEL------VYVDGIPV-AGKTHRYVIDLMHH-- 846

  Fly  3922 TRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISI 3986
                                                                      :||:..:
Mouse   847 ----------------------------------------------------------AARNGQV 853

  Fly  3987 NPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASG 4051
            |     :.||                          |::|..  |.|.|..|...|:.|...:|.
Mouse   854 N-----LTVR--------------------------RKVLCG--GEPCPENGRSPGSVSTHHSSP 885

  Fly  4052 GLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKV 4116
                            ||.:..|...|        |.||           :|.|:..:..|:   
Mouse   886 ----------------RSDYATYSNSN--------HAAP-----------SSNASPPEGFAS--- 912

  Fly  4117 STAGSQNKHSVPYQTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESP 4181
                    ||:  ||:     |||::..:........::........|....|:          .
Mouse   913 --------HSL--QTS-----DVVIHRKENEGFGFVIISSLNRPESGATITVPH----------K 952

  Fly  4182 FGQLLEMLP------YKV-----------ICRSPHLTDMLVKLL--ASLS--------------T 4213
            .|::::..|      .||           |...||..  :|||:  |.||              |
Mouse   953 IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHAD--IVKLIKDAGLSVTLRIIPQEELNSPT 1015

  Fly  4214 ELPKEEELLPLSDQMPPLVPIGPVQRAGAA---AAAAHPPPPQP 4254
            ..|..|:..|::.|..||....|:.:...|   :..|.|.||||
Mouse  1016 SAPSSEKQSPMAQQHSPLAQQSPLAQPSPATPNSPVAQPAPPQP 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 17/75 (23%)
DUF4414 3675..3779 CDD:291075 21/120 (18%)
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
Magi2XP_006535806.1 PDZ_signaling 22..96 CDD:238492
NK 118..290 CDD:388413 37/210 (18%)
WW 303..332 CDD:366073 3/28 (11%)
WW 349..378 CDD:366073 8/42 (19%)
PDZ 427..508 CDD:214570 17/88 (19%)
PDZ 601..682 CDD:214570 19/103 (18%)
MAGI_u5 681..755 CDD:374709 16/79 (20%)
PDZ 774..860 CDD:214570 27/204 (13%)
PDZ_signaling 919..1006 CDD:238492 18/98 (18%)
PDZ_signaling 1138..1218 CDD:238492
MAGI_u1 1245..1285 CDD:374706
PHA03307 <1255..>1407 CDD:223039
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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