DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Wwc2

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001102581.1	Gene:	Wwc2 / 498630	RGDID:	1559427	Length:	1194	Species:	Rattus norvegicus

Alignment Length:	1042	Identity:	196/1042 - (18%)
Similarity:	330/1042 - (31%)	Gaps:	401/1042 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  2895 PDDEVDDEDDDVDADPDG-DPDVDPISG-PSAAQAE----------------------AYLYERL 2935
            |.....||.:.::|:... :.::....| ||.|.||                      .|||.:|
  Rat   363 PQKRTQDELERLEAERQRLEEELVAARGLPSRALAERLKLEEKRKELLQKLEETTKLTTYLYSQL 427

  Fly  2936 GSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGSGQRSSTGGTTASIGAIA 3000
            .|             ::||..          :..|||:.|:..||.||...||.|    |:.:::
  Rat   428 KS-------------LSSSTL----------SMSSGSSLGSLASSRGSLNTSSRG----SLNSLS 465

  Fly  3001 SAALRPSS-GSWMAPDFNF-----IRISGGDSSMGSGPAIGGNANGGDMNVFITPSMSLERAGGA 3059
            |:.|..|| |..|..|:.:     ::..||  .:.|||....:.|    .|..:||.
  Rat   466 SSDLYYSSQGDQMDTDYQYKLDFLLQEKGG--YIPSGPITTIHEN----EVVKSPSQ-------- 516

  Fly  3060 PGSGQTMSELLNEQPTGAGGGGGGGSASGVGGVGANGGTTGQHPNATLCTNGV-----RRRL--- 3116
            ||.                        ||:.|:|.  ..|...|..|..:..|     |..|
  Rat   517 PGQ------------------------SGLCGLGV--AATSHTPPLTEASKSVTSLSSRSSLSSL 555

  Fly  3117 ------LYLDQQYCVCMPTHQNPTEETQMETFTQDALHWWLEEATLLDMESQTDACLYAAHFLLP 3175
                  |.||.       |....:.:|....||.|     ||:            |..:.||
  Rat   556 SPPGSPLVLDS-------TFPGSSHDTSPHQFTAD-----LED------------CELSRHF--- 593

  Fly  3176 HLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAV--- 3237
                                                              :.|  ||..|.|
  Rat   594 --------------------------------------------------ADI--GLGENQVLLD 606

  Fly  3238 -SAGSGSSSLVVPPVAASATGG-------------TRRSSIPVLISSTLGPSSASSATSATGNGA 3288
             .:|..|.||:........|||             .:|..:.:....|...|:|:|..|..|:..
  Rat   607 SDSGGPSQSLLEDKDLDECTGGLLYEGSADVEKSLPKRRGLHLRGDKTARVSAAASDESVAGDSG 671

  Fly  3289 TSDATTTTGGPTRNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSE--- 3350
            ..:|:                                 ::|..::....|.|.|:|..:.::
  Rat   672 VYEAS---------------------------------VKQPGEIEDIPYREEDVTIVETAQVQI 703

  Fly  3351 GDRSTSTTTGTAADGAESQSQH-----NSSSTAAQVAVPQHQRHPPVPLLPSSGRPS-------R 3403
            |.|..:.::......|:.::.|     :||....:|||           ||||...|       .
  Rat   704 GLRYDTKSSSFMVIIAQLRNLHAFSIPHSSKVYFRVAV-----------LPSSADVSCLFRTKVH 757

  Fly  3404 PHT---------RLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSAL--------------- 3444
            |.|         |:..::::|.|.|   :|..|...|........:|:.:
  Rat   758 PPTESVLYNDVFRVAISQVVLQQKT---LRVDLCSVSKRRREECLAGTQISLADLPFSNEIFMLW 819

  Fly  3445 INARPNRDLPACLQRHDHPAGSIFPRPSANRTPAPTLVSMPTPMSNAALEQLNVTAPDVVRTDRN 3509
            .|..|::.:| |.::.:  .|.   :|.| ::|.|.|.|......:|.|.:   |:.:::..::
  Rat   820 YNLLPSKQIP-CKKKEE--GGG---QPGA-QSPQPALDSADLDAVSALLAR---TSAELLAVEQ- 873

  Fly  3510 FALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGT 3574
                              :|.|:|.:.|:::  |.|....|..|...::
  Rat   874 ------------------ELAQEEEEEEEEE--LRPEHRGPGEDCLTML---------------- 902

  Fly  3575 REESSAPAVATES----TEAVNESNQPEPT---PESSESTSPNPQAPSAEPTPLEPGAAVDASVG 3632
            ||.|:....|.||    .|..:....|.|.   |.:|.......:..:.:|.  :|..||...|.
  Rat   903 REASAETVAAKESGVHLAEGGHCPEDPSPCTRGPGTSRDQCRKEKGRTEDPG--QPATAVPTLVD 965

  Fly  3633 AQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVP------------------------- 3672
            .:|  .|:||..:..|         :.|:.|::|.....|
  Rat   966 KET--NTDEAVDSNIA---------VRPKDRSSLSSQHHPFVRSSVIVRSQTFSPGERSQYICRL 1019

  Fly  3673 --EGVDPSFLAALPSEMREEVIQEHLRMQR------IRQRAQQNAIQIAHDSLVEVNPEFLAALP 3729
              ...|.|.||.....:|....:..||::|      :|:.||:..::.:.|..:::.........
  Rat  1020 NRSDSDSSTLAKKSLFVRNSTERRSLRVKRAVCQPTLRRTAQECPVRTSLDLELDLQASLTRQSR 1084

  Fly  3730 LNIQSEVL--MQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPELA 3792
            ||.:.:.|  :||::|:.:...:|..|...:....|.:.|.:..:||..|..|:.|      :|.
  Rat  1085 LNDELQALRGLQQKLEELKAQGETDLPPGMLGDERFQKLLKQAEKQAEQTKEEQKQ------DLN 1143

  Fly  3793 AE 3794
            ||
  Rat  1144 AE 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	21/82 (26%)
		DUF4414	3675..3779	CDD:291075	25/111 (23%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
Wwc2	NP_001102581.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		DUF342	<283..385	CDD:302792	4/21 (19%)
		YlqD	351..>420	CDD:287979	10/56 (18%)
		C2_Kibra	699..822	CDD:176062	24/136 (18%)
		Phage_Nu1	<1095..>1153	CDD:294991	15/57 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900