DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and arel1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001011393.1	Gene:	arel1 / 496863	XenbaseID:	XB-GENE-5852856	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	525	Identity:	158/525 - (30%)
Similarity:	251/525 - (47%)	Gaps:	79/525 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  4683 SSANTP----SSASFDDEPRMQDASTNTPLVTNPS------TSTAMSAHEAQLRQDRQKFLQFAE 4737
            ||.|.|    ||::.:||....|..| ...:..|.      |...:|..|..||....:...|..
Frog   301 SSPNIPGQHRSSSTSNDEESNADGHT-VDRLKKPKKVYFYITPKQLSVKEFYLRIIPWRLFTFRV 364

  Fly  4738 KHRTVLNQILRQSPTH------LSDG---PFAV--------LVDHTRILDFDV--------KRKY 4777
            ...|.. ..|...|.|      :.||   |..:        ....||.|..::        |..:
Frog   365 CPGTKF-LYLPPDPLHGLLSLQVDDGLQPPIEISCKDRNIMAATFTRFLHLNIGGSETFQDKVTF 428

  Fly  4778 FQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREW 4842
            ||.||.::.....|.:.|:.|.|.::.|.|.|........:|...|.:||:|||..|.||..|||
Frog   429 FQKELRQIHCKKTRCKVTLKVNRHSLLESSLRATRNFSASDWCKNFEVVFQDEEALDWGGPRREW 493

  Fly  4843 YVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPN-HLSYFKFVGRVIAKAVHDN-------K 4899
            :.:|.:.:|:....|| :...|....:::|:....|| .:..::|.|||:.|.:.::       :
Frog   494 FELICKTLFDTNNQLF-IRFSDSNQGLVHPNPCRPPNIRVKLYEFAGRVVGKCLFESSLGGGCEQ 557

  Fly  4900 LLECYFTRSFYKHILGKQVKHTDMESQDYEFYK-GLDYLMKNDISTLGYELTFSTEVQEFG---- 4959
            |:...|||||...|:|.::.:...|:.|.:|:: .:.|::.||:  :..||:|:.|  ::|
Frog   558 LVRARFTRSFLAQIIGLRMHYKYFETDDPDFFQTKVQYILTNDV--IDTELSFAEE--KYGRAGQ 618

  Fly  4960 VTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQEL 5024
            :.::.:|.|.|....||.|||..|:.|:...::|..:|:::|.||:|..:::|.:|:.||:|.||
Frog   619 LEKVVELIPGGSQILVTNENKVYYLNLLANHRLSNQVREEVDHFLKGLNELVPDNLLGIFDENEL 683

  Fly  5025 ELLISGLPDIDIEDLKANT-----EYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVP 5084
            |||:.|...|.::|.:|:.     .:|   .:...:.|||..:.|..|.:.|:.|||.||:|::|
Frog   684 ELLMCGTGHIAVQDFQAHAVVIGGSWH---FREKVMSWFWAVVSSLTQEELARLLQFTTGSSQLP 745

  Fly  5085 LQGFGSLEGMNGIQKFQI-----HRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHEC 5144
            ..||.:|.     ..|||     |      ..||.||||||||.||.|.||:::...|..||.|.
Frog   746 PGGFAALS-----PSFQIIGSPTH------GTLPTAHTCFNQLCLPTYDSYEEMHKMLKLAISEG 799

  Fly  5145 SEGFG 5149
            .||||
Frog   800 CEGFG 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	122/375 (33%)
		HECTc	4820..5148	CDD:214523	115/350 (33%)
arel1	NP_001011393.1	Filamin	56..153	CDD:366210
arel1	NP_001011393.1	HECTc	447..804	CDD:238033	122/375 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920