Protein Alignment HUWE1 and bag3

DIOPT Version :9

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001003533.1
• Gene: bag3 / 445139
• ZFINID: ZDB-GENE-040801-40
• Length: 459
• Species: Danio rerio
• Alignment Length: 592
• Identity: 111/592 - (18%)
• Similarity: 170/592 - (28%)
• Gaps: 241/592 - (40%)

  Fly  3290 SDATTTTGGPTRNFSSVDSN---VSSETQ--------TTTRPPRQRGGLRQQSQLPFNIYAEIDL 3343
            ::.|||...|..:...:.||   :|.||.        ...|.|..|.|           |..|.:
Zfish    28 NNRTTTWNDPRHDTKKIFSNGPSMSPETPQDMHKTFINEMRQPMLRQG-----------YIPIPV 81

  Fly  3344 TNEQDSEGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQR---HPPVPLLPSSGRPSRPH 3405
            .:|                  ..|.:.|...|.:....||.|:.|   ..|.|...:..||..|.
Zfish    82 CHE------------------NPEPRLQQYPSFSYIHPAVQQNLRTDGRTPSPTPAAHCRPRSPV 128

  Fly  3406 TRLDET-----------ELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSAL---------INARPN 3450
            ....|.           |....|.|.:||       ||.....|:|.:.|         |:....
Zfish   129 QTPSEACSSCSPTSHGPEGYQPQGTHQQI-------SGLHQQPRSSNTGLRAGYIPIPVIHEGAG 186

  Fly  3451 RDLPACLQRHDHPAGSIFPRPSA------NRTPAPTLVSMPTPMSNAALEQLNVTAPDVVRTDRN 3509
            ..||:.|.:..||......|...      ||..:|  :.:|....:..:.|:....|.:.:...:
Zfish   187 GVLPSQLSQSSHPTREKIYREQVPIQIQQNRAASP--IQVPLRAQSPVMAQIMGERPQMQQHIGH 249

  Fly  3510 FALPSSLEVDVD----------VLPGIVDLPQQ-EAQPEDDQLLLPPPPPPPPSDTTPLVHAEDD 3563
            .|:||.:|..|:          .:..:.::||| ..||...|  ..|...|.|
Zfish   250 TAIPSKIEHPVEEIIRVPTFEVPIQRVSEVPQQIHHQPVQQQ--QQPTQQPQP------------ 300

  Fly  3564 LWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAAVD 3628
                                            :.:|:|:.||:::...|.|.| |.|.|..|
Zfish   301 --------------------------------KAQPSPQVSETSNITIQVPPA-PEPQETAA--- 329

  Fly  3629 ASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQ 3693
                   |.|.:|..|           :.:.|                            ||.::
Zfish   330 -------PQTPQEVPS-----------SQLQP----------------------------EETLE 348

  Fly  3694 EHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPV 3758
            :.|                :|..||:|                  ||.:|:..:.||.....|..
Zfish   349 QDL----------------SHPGLVKV------------------QQIVERVEKLAQNVKGFDGK 379

  Fly  3759 DTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQ 3823
            .....:..|.|.|.:.:|.      :.|:.||...:.:..|||     |.|           |.|
Zfish   380 KNDKRYLVLEEMLTKELLA------LDSVDPEGRPDVRQARRD-----GVR-----------RVQ 422

  Fly  3824 TTLQSLD 3830
            ..|..|:
Zfish   423 NILDELE 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	15/75 (20%)
		DUF4414	3675..3779	CDD:291075	17/103 (17%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
bag3	NP_001003533.1	WW	6..38	CDD:197736	3/9 (33%)
		BAG	358..432	CDD:214591	23/112 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900