DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and kibra

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster


Alignment Length:1327 Identity:233/1327 - (17%)
Similarity:419/1327 - (31%) Gaps:430/1327 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1219 QTRQRRINDLISNITKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLICSVGFTGPM 1283
            |.:|:..:|.       |.|:..:||:        .|..::.....:.| |.|:|.....:|.|.
  Fly    45 QQQQQHHSDF-------PLPDGWDIAK--------DFDGKTYYIDHINK-KTTWLDPRDCYTKPQ 93

  Fly  1284 LFDDKRSAFHLMISQFCAENGLKAFFEMFY----WALSLDNVSQKFEFD----QWASMEDLMQSH 1340
            .|:|            |..:.|...:|..|    ....:::::|..:.:    :|.::::.|.| 
  Fly    94 TFED------------CVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLS- 145

  Fly  1341 EDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYMPDSVPFEPVFYLIHIHQLAM 1405
                        ::|.|....||   |.|.|.|                               :
  Fly   146 ------------DYLSAAQDQLE---NKREMFD-------------------------------V 164

  Fly  1406 QALRRIWARR-------------------PIPNYGPSMFETMILILKHLIKSHQTLLDRYHTRMK 1451
            :..|.:||:.                   .:..:.|.:....:::.:          :|.|...:
  Fly   165 KQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLAR----------ERVHQLKQ 219

  Fly  1452 EIKFENLYIRSTDDGLNADHIKTLTDMG------------FMHYHVI--EALRTNASL------- 1495
            |:......|..|:.|:|     ||..:|            ....|.|  |.|:.:.||       
  Fly   220 ELTHITNDISYTERGMN-----TLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVR 279

  Fly  1496 EEATDYLLNNPEASSLSTTGGQSSSSAPPPPPPPSASTMDIDVDVPADGESTQ--SKSSTSPNSS 1558
            ||....|:.............::|..|.|......||..|:   ..:.||:..  ::.:....:.
  Fly   280 EELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDL---CGSSGENLNGGARFAEMAKTK 341

  Fly  1559 YDY----KHLKLMPSLIFDRFCDEAISRAFEFMEAI-PDTVNSAADLIAVLYRRHNHLN------ 1612
            :.|    ||:|.:...:.|.            :|.| |..:.|..|.|.::..:...||      
  Fly   342 WQYAEWRKHIKKLQQQLADH------------VERIEPGQLESDKDRILLIQEKEKLLNDLNSIS 394

  Fly  1613 ------KQVFVTNFVRNIIQWVDFTLQLFEPAKTTGSKASRLEECLTGMTATRLFVRLKTSTLLL 1671
                  ::..|.:..|:.::  :...:.:|...|..:...|..| ...:...:|...|| ||.||
  Fly   395 LKSRSEEEKRVIHQTRHKLE--EDLKEAYEANNTCVANRLRFHE-EKQLLLDKLQEALK-STKLL 455

  Fly  1672 EENYSDLHRPLVEAITAQDAMVSLVKLLDCMSQWMLEQSTETNTGQQRATV--------PRWVQN 1728
            ||...........:|::..::.||                  :|...::.:        |..|.:
  Fly   456 EERLKSFSSESTFSISSGSSLGSL------------------STASSKSALSFTDIYIDPFAVDS 502

  Fly  1729 LVDLID---------------AIDSISHILQRKANMRAV----SSDVWRWYDASTGKWNAYSEAN 1774
            .:|::|               .:..:..:||::.:....    ||.......||..|:||.::..
  Fly   503 PIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQT 567

  Fly  1775 NELIRNAYAAGERWLYINIGRQRCTVSLNCMTQVSEASGTHRPVCPALKLSEAITSLNNPVALHK 1839
            .:.::      |...|.|                            ||....|.|: ..||.:..
  Fly   568 PQALK------EEPTYAN----------------------------ALPAPPAYTA-PPPVPISG 597

  Fly  1840 VEHILNRVVRTAP-DGSGTVHSDELISLRQLVNFTDGQQPQQSENSANPSEEATSEDGPAAANSG 1903
                    ||..| |...||....::..:           .|..|...|...|.:   |.:..|.
  Fly   598 --------VRARPYDLDSTVLDCMMLEAK-----------LQKLNMGTPLNLAVA---PLSPISE 640

  Fly  1904 SP-----PATMTTRSKTRQKSAAAAAAAKNKSQSGGS-------PPIPKRTQKIILNEEQVGLSK 1956
            .|     |..|.:||.:...:.:.:||..|:|.:|.|       ..:|::.    |.:.|:||..
  Fly   641 KPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKE----LAQVQIGLKY 701

  Fly  1957 FDCGRIIGSIVDLLQPSHQMLNETKLSLLRLCARLTRNYDNAQVFIRRGGVRMLLHLQQACSFMG 2021
            .   :..|.:|..|:.::.:|           |..|.:.||:||::|   ..:|.:...:.....
  Fly   702 L---KQEGVLVVSLERANNLL-----------ALWTASADNSQVYLR---AALLPNSLTSIRTKA 749

  Fly  2022 FPTYANIILRHVLEAPPVLQEAMERVLGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAK 2086
            ...:...:.......|..|.:.:.:  .::...:...|.::.|....|:|.| ..||:.......
  Fly   750 LGDFQKPVFNDTFAVPITLDKLLTK--SLQVTVVTMTGQKEEIIGTVQISMA-EFNPEDSTLKWY 811

  Fly  2087 EMLKGEYLINTNS----TTLADDARVMVKSKFGQQP-------------TAAAGGATPHNQTP-- 2132
            .:|..:::.:..|    :|.|..|...|.:.....|             |::.......||.|  
  Fly   812 NVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCM 876

  Fly  2133 ----------------TPPPAAKD------ELKDDPQVQSSVAVL--KELLHGLVQPCWHYGGTG 2173
                            ..|..:.|      |..||.|:.|.|.::  ..:||..:|..    ...
  Fly   877 ELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNM----KQE 937

  Fly  2174 SLDRGQGAAELLQPDQPPGTAQGCHDDELYFRFQE-TPAPVSSKKQ-----SSSGGGAAAAGQTG 2232
            ..|:.........|::..|.:| ..||....|.|. ||:...||.:     :.|...:|      
  Fly   938 FADKETNTDRAYLPEKSRGQSQ-LMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSA------ 995

  Fly  2233 QATEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVL--LSHVYTPADSPL 2295
                        .|...:.||..:....|.:|         .:.|..|:.:  |.|.:.|..|  
  Fly   996 ------------MHCGVAPHTFQRGAAERRSL---------RFHSKAPKSVTKLHHTHIPRTS-- 1037

  Fly  2296 ISAPQQTFLGVLLDRFLPITQRH--------HVPEVSTMTRVL--ICSLSDCYQQPGVQVHVA-- 2348
                        ||..|.:..:|        .:.::..:..||  .|...|    |.|.....  
  Fly  1038 ------------LDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKD----PLVAAWAIEN 1086

  Fly  2349 EELHAAVARALAQPDSAEKHTRLQVLM 2375
            ||....|||  |.|....:..:||.|:
  Fly  1087 EEFQRLVAR--ADPAKCPEERQLQKLL 1111

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366 13/59 (22%)
WWE 1756..1828 CDD:128922 10/71 (14%)
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
kibraNP_001034055.1 WW 57..87 CDD:238122 8/38 (21%)
WW 103..132 CDD:278809 4/28 (14%)
C2_Kibra 693..813 CDD:176062 24/139 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.