DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and hyd

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster


Alignment Length:2970 Identity:555/2970 - (18%)
Similarity:938/2970 - (31%) Gaps:1015/2970 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  2626 VVNFDQ---LWDDF---LQSEGLRLASRSGGGAG--------SGSGSVGASSS------GQQNGS 2670
            |:.|||   |||.|   .:.....:|:....||.        ..|||:|.:.|      ||...|
  Fly   487 VLPFDQRRFLWDKFRTKTKKPFKVVATDINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNS 551

  Fly  2671 NTTASST------NSGNNSGIGNLRLRTN--------PDVDV-------GSGNGSGSGSGSNAGV 2714
            ..|.:..      |...|||:...:...|        ||.|:       .:|:.....|.||:..
  Fly   552 VWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPSTGSSKNGQSFSNSKE 616

  Fly  2715 VNDNGISGGGGSDGASTSSDTGAPGGARDLNASLLGDVSTSESDSDPSTENDERNEEDEDEDDDA 2779
            ..|........|..:||.||||:               .||...:..:|..         ||.:|
  Fly   617 STDRIDMPPPPSPASSTCSDTGS---------------VTSHKRTKRATTK---------EDSNA 657

  Fly  2780 PDEDVDEHSETDVDEERSRQFIEVFDHIYEPESSETASNDADVDNDDDDDEDDVDDDDDDDEDND 2844
            |.|.           .:..:..||.|.::..:..........||.|                   
  Fly   658 PQEG-----------RKDEELWEVKDVVFVEDKVGPVGKVLKVDGD------------------- 692

  Fly  2845 DDVREEVQSVMDAEIENRIDIALALVSSNNRPRRSAAVNASGDGSANRTNPDDEVDDEDDDVDAD 2909
                               .:|:...:.|  ....||..|:...::|..:...|...|||     
  Fly   693 -------------------FVAVRFPAIN--AAAVAAAAAATSSTSNTASTSKEEGKEDD----- 731

  Fly  2910 PDGDPDVDPISGPSAAQAEAYLYERLGSGLMPTPPVGFRVRMNSS-----IAQPLDIDVNGGNAG 2969
                            ..:..|..|....:       ||..|::.     ..||..|:|.|..||
  Fly   732 ----------------WQQCRLLRREDVQI-------FRTAMSTRGPDWLQKQPKKINVGGDAAG 773

  Fly  2970 SGSNAGATGSSGGSGQRSSTGGTTASIGAIASA-----ALRPSSGSWMAPDFNFIRISGGDSSMG 3029
            :.....|..|.|....:...|....|:..:.:.     .|.|:                      
  Fly   774 AQILTLAVDSRGIHVIKKVLGKIHYSLYNLYNCKQEQNCLFPT---------------------- 816

  Fly  3030 SGPAIGGNANGGDMNVFITPSMSLERAGGAPG----------SGQTMSELLNEQPTGAGGGGGGG 3084
                        |.|.||         |..||          ||.:.:.:|.:         |.|
  Fly   817 ------------DCNSFI---------GSTPGNILMACNDDCSGNSSTIVLRD---------GNG 851

  Fly  3085 SASGVGGVGANGGTTGQHPNATLCTNGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQDALHW 3149
            :.               :|.|..|...::      |.|: ..:|    |.:...|.|.:..|:  
  Fly   852 AL---------------YPLAKDCLGSIK------DPQW-FDLP----PVKSITMSTISLPAM-- 888

  Fly  3150 WLEEATLLDMESQTDACLYAAHF----LLPHL----IKELKAAHQQRKQEEAARQS--------- 3197
                  |..:..::..|:.|..|    |:||:    :|...||..:.::|:.|..:         
  Fly   889 ------LSGVNLKSKVCMTALLFDTQKLMPHILRCDVKNSFAALGRLEREDQADTALVVEERCDG 947

  Fly  3198 -----------TTPASGSNASATSSS----TTSVVGTAA----PTAT-----SSIASGLLANAVS 3238
                       ..|:|..::...|.|    ..|:||.:.    ||.:     ||||.|  |:|.|
  Fly   948 ARNIFHACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFG--ASASS 1010

  Fly  3239 AGSGSSSLVVPPVAASATGGTRRSS-------IPVLISSTLGPSSAS----------------SA 3280
            :...||...:...||.:...|.|.:       :..||:|.....|.|                :.
  Fly  1011 SNENSSFATMSSSAAGSASSTSRDNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDHAYIPWPAE 1075

  Fly  3281 TSATGNGATSDATTTTGG---------PTRNFSSVDSNVSSETQTTTRPPRQR------------ 3324
            |.|..|.:.|.:...:..         |:.:.||:.||:...:.|.|....||            
  Fly  1076 TPAASNLSASSSQNVSDSIEDDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQMC 1140

  Fly  3325 --GGLR-----------QQSQLPFNI-------YAEIDLTN------EQDSEGDRSTSTTTGTAA 3363
              ..||           .|.|.||.:       .|.|.|.|      |||.:...:.....|:.|
  Fly  1141 VSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQDPQLKEAMIFPNGSPA 1205

  Fly  3364 D------------------GAESQSQH----------NSSSTAAQVAVPQHQRH--------PPV 3392
            |                  ||:..:|:          .|.....:.|...|:.|        |..
  Fly  1206 DQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKLKRTAPTA 1270

  Fly  3393 --------------------------PLLPSSGRPSRPHTRLDETELLLLQLTDRQI-------- 3423
                                      .|:..:...::.:::.:...|.|:|...|||        
  Fly  1271 YCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQRQYRF 1335

  Fly  3424 ----RNRLQGSSGHTNSS------RTSGSALINARPNRDLPACLQRHDHPAGSIFPRPSANRTPA 3478
                ||....::|.|.::      :||.:.:.|..|:.||.                        
  Fly  1336 SVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLE------------------------ 1376

  Fly  3479 PTLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLL 3543
                  |...:..|||:|.:....|    |:..:..:...||   |.......:.:..|...:.:
  Fly  1377 ------PPKFARKALERLLIDWNAV----RSMIMSGAERGDV---PNPAGSASENSNSEGFNMFI 1428

  Fly  3544 PPPPPPPPSD--TTPLV--HAEDDLWPGTVVSAGTREESSAPAVATESTEA-------------- 3590
            .........|  |..|:  ...|.|  .|::....||..:| :|:..|.||              
  Fly  1429 QTQHGSTLLDKFTHSLIVKCTSDHL--DTLLLTLVRELQNA-SVSNRSKEAEEVVRRFVRSVARV 1490

  Fly  3591 ---VNESNQPEPTPESSESTSPNPQAPSA-------------EPTPLEPGAAVDASVGAQTPATT 3639
               .|...||.|....|.| |.|....|.             |...:.........:|...|.  
  Fly  1491 FVIFNLEKQPNPEKRKSHS-SCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPT-- 1552

  Fly  3640 EEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQR 3704
              |..|..:|......:|          ||   ..|||...:.:.|...:.::.:....|.....
  Fly  1553 --APFTMSSSNLDVRNSD----------DL---FSVDPLAPSNVESPSEQILVHDAGNDQSANFN 1602

  Fly  3705 AQQN-------AIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQT--------ANP 3754
            .|||       .|:.|.:|...:|.|   |...|...|::..||.|...|..::        |..
  Fly  1603 IQQNYDVVAMETIRDASESEEVINRE---ANSHNQDDELIENQRNEDGMQDDESDNDFTFNDAET 1664

  Fly  3755 EDPVDTAAFFQNLPENLRQAILTDMEESQIASL---------------------PPELAAEAQFL 3798
            |...|.....|.:..:: ||..|...|:.|..|                     ..:.:.|..|.
  Fly  1665 ESDSDDNQSNQEVQRSV-QAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFN 1728

  Fly  3799 RRDWESR---NGARMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGN---AQPQHHQHTTI- 3856
            .:..|.|   :.||.|..|.:     .|..::|.|..|  ||:......|   ..|...:.:|: 
  Fly  1729 EQQLERRSTNSNARSDLAPQT-----MQWAIRSRDTAR--SSVRVPTGSNMVFIDPMALRRSTVP 1786

  Fly  3857 ---------VHQHPHAHHAPNMGKPLALLMMEDENI--LLDPDSLATLLLFLFVEDQKVNSMRLH 3910
                     :..|..|..|.|:.:...:.:.:...:  :|..:.|..:...|.:::.:..:::..
  Fly  1787 ASTTVTTPSIEPHTMATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAF 1851

  Fly  3911 RVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINR 3975
             |.:.|   :.|.||:.:     :....|....|||                   |.:|.     
  Fly  1852 -VEKRL---KATWDWMFT-----VMDGTEAQLKFGA-------------------YLTNY----- 1883

  Fly  3976 LYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFGMPSPTAGSG 4040
                      .:|                   ::|  ..|.|...:|....:     |:|     
  Fly  1884 ----------TDP-------------------NHP--LHPLNLSAQASSSQT-----PAP----- 1907

  Fly  4041 GGAGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKA 4105
                   |.|..:.|.:.:......||.: :|    ::.:||...:|   :.::|:.:..:....
  Fly  1908 -------ATSSSVNGVNIMGSNSRRDFFT-YC----LSLMRSHTSEH---RDALPVLDITALRHI 1957

  Fly  4106 AAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDV-------VLNIDQQTQV-----RLANVAQF- 4157
            |....|              .|.|..|...|:|.       :.|:...|:.     .|||:.:| 
  Fly  1958 AYVLDA--------------FVYYMRNDSGFYDKQDTISGRINNLSPMTESYDTDDELANLEEFN 2008

  Fly  4158 -----PLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPK 4217
                 ..:|.|:.........|.:.|||..         .:.|.:|.            ..|||.
  Fly  2009 ADVQMSASSMPSGSQGTRRHAFFARSESTL---------SLGCSAPE------------GFELPL 2052

  Fly  4218 EEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDG-------------- 4268
             :..:||:|:...|.|....|.     ..|:.|.......|.:.||..|||              
  Fly  2053 -DMAMPLADKPHLLQPNSKRQE-----LFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFS 2111

  Fly  4269 --LAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVL 4331
              |..|.....:....:..:||.|...|.......::.:.:     ::|..|.:|.         
  Fly  2112 NSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQL-----KKKQGSDDFK--------- 2162

  Fly  4332 THQCGTTEG-LDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQ 4395
            :|:  ..:| .....|:::..|..|..|::    ..|.|::....||..|               
  Fly  2163 SHK--EADGNQSKYEKVVLMETDDSLPSTS----KSTEALMATRPEVIIA--------------- 2206

  Fly  4396 GGAGTTSQAASTSGAAAATASYVPTVSGASLL------------PNLAVHEGIMQD----RFTAE 4444
                  ...||.|.|.||.:  |..::|.|.|            .||:..|....|    :.|::
  Fly  2207 ------PNKASVSPATAARS--VIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSD 2263

  Fly  4445 HVIISAPKNAK--PTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQV------------------- 4488
            |:::...:.::  .:...:|||...|:|.      :..||.:|.:|                   
  Fly  2264 HLLLFPARGSQFYQSNFSELPSWNFLLSR------WKLTLDLFGRVFMDDVGMEHGSVLPELRGF 2322

  Fly  4489 --------RDMYEAQNGLSTGGGVACGAGDNDDD-IIDIEGDGGASGGSSSDMAPGSASTISPPP 4544
                    |.|.:.:|| .....|.|....|.:. |:....:.....|:.|...         .|
  Fly  2323 PVKEMRFRRHMEKLRNG-QQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRI---------QP 2377

  Fly  4545 PMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEE 4609
            |:..|::.....|:          ||.|:....|                 .:.:::|.|:|..:
  Fly  2378 PITFNRVKVTFKDE----------PGEGSGVARS-----------------FYTSIAEALLASAK 2415

  Fly  4610 SKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQE 4674
            .          |.:|: ..:..:|       .:..:|.::....|..:|            |:::
  Fly  2416 I----------PNLES-VQVGTNH-------SKYVVPFSSILRSRTVSG------------SSRD 2450

  Fly  4675 YSPFMDDVS-------SANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQD-RQK 4731
            .|......|       ||....:.:.|..|.....|::.  .|..|.:..:|.|..|:.:. ..|
  Fly  2451 QSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDN--ATPESLNDHLSVHLQQIGERLYPK 2513

  Fly  4732 FLQFAEKHRTVLNQILRQSPTH--LSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEH 4794
            .....:.|...:..:|.:.||.  ||            ::..|      :|..::::|.|  |..
  Fly  2514 IHSINQTHAPKITGMLLEIPTPQLLS------------VISSD------ETLRQKVNEAI--EII 2558

  Fly  4795 TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFE--DEEGQDAGGLLREWYVIISREIFNPMYAL 4857
            |...:..|..:.|         :..|:...:|.:  |::.:                   |::  
  Fly  2559 TFKQKSETSAQSS---------QPKKSPSVVVVDPVDDDNE-------------------PLF-- 2593

  Fly  4858 FCVSPGDRVTYMINP-SSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHT 4921
              .|||.|..|  .| ...|:...::.|:.:||:|...:..|:||..:..|...|:|||:::|..
  Fly  2594 --YSPGKRGFY--TPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFH 2654

  Fly  4922 DMESQDYEFYKGLDYLMKNDISTLG------YELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENK 4980
            |:...|...|:....:::|..:..|      .||.|..::.:......|:|.|.|||.|||..|.
  Fly  2655 DLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNI 2719

  Fly  4981 FEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEY 5045
            ||||:...:.::..|..:.|:|..:|.:|::|.:.:.....::|.||::|:.||::..|.:.|.:
  Fly  2720 FEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTF 2784

  Fly  5046 HKYTSKSAQ-----IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRD 5105
            :..:|:...     .:|||..:...:..:|...:.|.||:..:|    .|.||...:....|...
  Fly  2785 NDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALP----ASEEGFQPLPSVTIRPA 2845

  Fly  5106 DRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGF 5150
            |.|  .||.|:||.::|.:|:|.|...|||.:|.||.  |:.|||
  Fly  2846 DDS--HLPTANTCISRLYIPLYSSKSILRSKMLMAIK--SKNFGF 2886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 22/105 (21%)
DUF4414 3675..3779 CDD:291075 27/118 (23%)
HECTc 4796..5149 CDD:238033 93/366 (25%)
HECTc 4820..5148 CDD:214523 91/341 (27%)
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698 8/66 (12%)
ASF1_hist_chap 1535..1733 CDD:304562 40/218 (18%)
PolyA 2498..2561 CDD:197769 16/82 (20%)
HECTc 2589..2885 CDD:238033 88/328 (27%)
HECTc 2589..2884 CDD:214523 88/327 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446988
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.830

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