DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and ctrip

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster


Alignment Length:3559 Identity:678/3559 - (19%)
Similarity:1086/3559 - (30%) Gaps:1298/3559 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  2443 SVSTTTLGSKRILFGSGGPGGPNASGNGNNTAGGSSGNGPGSGN--------------TYGTIIN 2493
            :.::.||.:|        ..|.|.:...|:::.....|...|..              |.|..::
  Fly    24 TATSATLANK--------TSGTNTTSASNHSSQRRRNNNTNSNRNKSHHKNEKRNAPATSGPAVS 80

  Fly  2494 RRLYPRLAARTGFGSAMERSNAMGGEHVLRDIIRNVLSDR------------RHAFEFIFNSDDM 2546
            ..:....|..|...::..||.:.|     |......||.:            |......|||  :
  Fly    81 SSVDVVPATSTASATSTRRSRSQG-----RHSSAAALSSKESQIPKRSVGAIRSPSSPAFNS--I 138

  Fly  2547 AVDSEDAAAPGS--------------------GVGGGGSGA----------GSVGGGV-SGSVSG 2580
            .|.|:.:.:|||                    ...||....          .|:|.|: .|:|..
  Fly   139 PVVSDQSLSPGSRKRQLNQHNNSNNKASSSHQSAPGGDQLVCAPLKKRRLQQSLGSGICEGAVEI 203

  Fly  2581 NSSAAVIDVVEERSNG--------GDTNDPPANVSSASSGAGQSSTSGGPVRPVVNFDQLWDDFL 2637
            |..||..|....:::|        ..|..|....|::|:.|.:..    .:||..:         
  Fly   204 NLGAASFDHTPRQASGDCVAQRTRSKTISPEELPSTSSAAAARHH----QIRPSAS--------- 255

  Fly  2638 QSEGLRLASRSGGGAGSGSGSVGASSSGQQNGSNTTASSTNSGNNSGIGNLRLRTN--------- 2693
                  ..|.|.........|:|.|.:..:...:...::..:|.:..:.|...:|.         
  Fly   256 ------STSFSSSHRNKRKASIGGSIAAVETTPHRGTAAARAGRSGNLLNYYRKTRKVSHTRSSQ 314

  Fly  2694 -------PDVD-VGSGNGS-GSGSGSNAGVVNDN---------GISGGGGSDGASTSSDTGAPGG 2740
                   |..| ..:.||| ||||.|.:||:..|         .:.....::..|.:::||....
  Fly   315 KSEKQSIPAEDTTANRNGSAGSGSSSKSGVIPKNRKSLRHSQQNLLDTEAAEVESAAAETGGEQQ 379

  Fly  2741 ARDLNASLLGDVSTSESDSDPS----TENDERNEED-----EDEDDDAPDEDVDEHSETDVDEER 2796
            :...|..::..:.|.|:..:.|    ..|..:.|.|     :||||:..||:.:|..|.:|.   
  Fly   380 SEHGNLDVIDQLPTPEAGPNQSEASGIHNQSQLEADRQPVVQDEDDEEDDEEEEEEEEEEVG--- 441

  Fly  2797 SRQFIEVFDHIYEPESSETASNDAD----VDNDDDDDEDDVDDDDDDDEDNDDDVREEVQSVMDA 2857
                      .|...:|..:|.:.|    .:.|:...|::|||:|||:.:.:|....|....:..
  Fly   442 ----------FYGIVNSAGSSYEEDTQIVAEEDEITTEEEVDDEDDDEIEEEDLSESEFAQQLIG 496

  Fly  2858 EI------------------ENRIDIA---------LALVSSNNRPR-----RSAAVNASGDG-- 2888
            |:                  .|...:|         .|..||..:.|     :.||..|.|.|  
  Fly   497 ELGGERQQPQRATNNAKKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHGQGAAPGAGGGGPR 561

  Fly  2889 ---SANRTNPDDEVDDEDDDVDADPDGDPDVDP------ISGPSAAQAEAYLYERLGSGLMPTPP 2944
               |:|..:.::.|             |..:.|      .:.|.|...:.:..:|    ..|.||
  Fly   562 ATRSSNSNSSNNVV-------------DYSIMPHLTTVATTTPHALTPQQHQQQR----QPPQPP 609

  Fly  2945 VGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGSGQRSSTGGTTASIGAIASAALRPSSG 3009
            ...:.:::.....|..:..:                 .....||....||:..|.|:||..|.:.
  Fly   610 SHQQQQVHQQQQPPQLLPTH-----------------QFAHLSSFVTPTAAAAAAAAAAHYPPAS 657

  Fly  3010 SWMA----------------------------------------PDFNFIRISGGDSSMGSG--P 3032
            :..|                                        |..:|       :|.|:|  |
  Fly   658 AAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHF-------TSTGAGPPP 715

  Fly  3033 AIGGNANGGDMNVFITPSMSLERAGGAPGSGQTMSELLNEQP-------TGAGGGGGGGSASGVG 3090
            |:........:..: ||:.:...|...|...|.:  :.|.|.       ..:.|..|...:|...
  Fly   716 ALFQQQAPPQLTRY-TPATATTAATFVPPQQQQV--VYNPQQQQHSSLRRSSRGKTGSCVSSAAA 777

  Fly  3091 GVGANGGTTGQHPNATLCTNGVRRRLL-----YLDQQY----CVCMPTHQNPTEETQMETFTQDA 3146
            ..........||.:|..   .|:::||     |..||.    .|....||...::.|.:. .|.|
  Fly   778 AQQQQHHQQQQHSSAAA---AVQQQLLPPPGTYQYQQVGGNTVVVAVRHQQQLQQQQQQQ-QQLA 838

  Fly  3147 LHWWLEEATLLDMESQTD---------ACLYAAHFLLPHLIKELKAAHQQRKQEEAARQSTTPAS 3202
            ||...::......:.|..         |.|....||..:      .::|.::|::.|:|......
  Fly   839 LHHQHQQQQHQQQQQQHQQQQHQQQQRATLVQPGFLFSY------RSNQPQQQQQPAQQIHQGPK 897

  Fly  3203 GSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVPPVAASAT----GGTRRSS 3263
            .:::||.|.:.|..:....|.:....|.|   ..::.|:.|::|.:...|.||.    ||:.   
  Fly   898 VTHSSAASDALTYSLMAQQPPSGPPHAGG---QQITPGANSANLSIVAAALSAARDVGGGSD--- 956

  Fly  3264 IPVLISSTLGPSSASSATSATGNGATS-DATTTTGGPTRNFSSVDSNVSSETQ--TTTRPPRQRG 3325
                     |..||..||.|||..|:| ..|:..|..:.:.||.....||.:.  |.|......|
  Fly   957 ---------GGGSAGGATPATGASASSVGNTSAVGASSSSNSSAGQAASSNSNNVTATGSGSAPG 1012

  Fly  3326 GLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHP 3390
            |                        |..||.||:||         ||.|.|.|| .||.......
  Fly  1013 G------------------------GPTSTGTTSGT---------QHGSGSGAA-AAVDSESDDS 1043

  Fly  3391 PV----PLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNR 3451
            .|    .||.:.|.|  ||         |......::.:.|..:.|:::||:.:           
  Fly  1044 EVGRLQALLEARGLP--PH---------LFGALGPRVTHILHRTIGNSSSSKAN----------- 1086

  Fly  3452 DLPACLQRHDHPAGSIFPRPSANRTPA------------PTLVSMPTPMSNAALEQLNVTAPDVV 3504
            .|...||.||.         |.....|            .||...|......||.||       :
  Fly  1087 QLLQGLQSHDE---------SQQLQAAIEMCQMLVMGNEDTLAGFPIKQVVPALIQL-------L 1135

  Fly  3505 RTDRNF--------ALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAE 3561
            |.:.||        ||...||.          ||:..                            
  Fly  1136 RMEHNFDIMNNACRALAYMLEA----------LPRSS---------------------------- 1162

  Fly  3562 DDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAA 3626
                 ||||.|       .| |..|..:.:...:                              .
  Fly  1163 -----GTVVEA-------VP-VFLEKLQVIQCMD------------------------------V 1184

  Fly  3627 VDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEV 3691
            .:.|:.|....:.....:...|:|.:|.:|.:                   .|.:.:        
  Fly  1185 AEQSLSALEILSRRHNKAILQANGISACLTYL-------------------DFFSIV-------- 1222

  Fly  3692 IQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPE---FLA-ALPLNIQSEVLMQQRIEQQRQAAQTA 3752
                         ||:.|:.||.:..:.::||   |:| :|||      |.:...:|.::..::.
  Fly  1223 -------------AQRAALAIAANCCLNMHPEEFHFVAESLPL------LARLLSQQDKKCIESV 1268

  Fly  3753 NPEDPVDTAAF------FQNLPENLRQAILTDMEES--QIASLPPELAAEAQFLRRDWESRNGAR 3809
                   .:||      ||:..:.|:|....|:.::  |:..:.|.:.....|..   ..|..:.
  Fly  1269 -------CSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILNTGTFTA---VVRMLSL 1323

  Fly  3810 MDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQP--QHHQHTTIVHQHPHAHH------- 3865
            |....|..|:|..:..:.        :::.|..:|||:|  ....|..::.:.|...:       
  Fly  1324 MCCSCPDLAISLLRNDIA--------ATLLYLLTGNAEPAAASATHVELISRSPSELYELTCLIG 1380

  Fly  3866 --APNMGKPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLH---RVIRNLCHHEPTRDW 3925
              .|.:  ||..:...|.  |||..:|.|       :||      :|   |..|...|:..|.| 
  Fly  1381 ELMPRL--PLDGIFAVDS--LLDRPTLNT-------QDQ------VHWQWRDDRGSWHNYSTID- 1427

  Fly  3926 IISALIS------------------------IIQKTNED-----------NANF----------- 3944
              |.||.                        .:|:.|||           |.|:           
  Fly  1428 --SRLIEAANQSSEDEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLT 1490

  Fly  3945 ----GAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAAQMIVRNCLD----- 4000
                |:..|||..  ......||....:|    |........|:::|    |:..|..||     
  Fly  1491 TTSAGSAAAGGAS--TSAAAAAASSNNNN----NNNNNPPGNSVNLN----QVKRRPSLDARIAC 1545

  Fly  4001 --------------LLFVLAKHYPSSFVPFNRDVKARRILSAVFG--------------MPSPTA 4037
                          :..||.:.|.||..|..|....|.:|..|:.              :.|..|
  Fly  1546 LKEERGLAADFIKHIFNVLYEVYSSSAGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSSHIA 1610

  Fly  4038 GSGGG------AGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDD------HPAP 4090
            |..|.      .|:...|...:....||       |.:.|.|..|:.:...:.|.      :|:|
  Fly  1611 GMLGSNDLRIVVGALQMAEILMRQLPDV-------FGTHFRREGVIYQFTQLTDPNNPICANPSP 1668

  Fly  4091 KP---------------SVP------------LDEAPSTSKA----------------------- 4105
            ||               |.|            :|.||..|.|                       
  Fly  1669 KPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNA 1733

  Fly  4106 --AAAKAA------ATAKVSTAGSQN-KHSVPYQTN---AKNFWDVVLNIDQQTQVRLANVAQFP 4158
              |:||..      ||:..:|||..| ..|.|..::   |..|      :.||...|     |:.
  Fly  1734 LTASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYF------VTQQGDPR-----QYV 1787

  Fly  4159 LTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEELL- 4222
            ...|||....|...:.|.......||.:..:.|:     ||.......:|||.|:......... 
  Fly  1788 HFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQ-----PHHQQPAHLVLASTSSGAASSSSSSS 1847

  Fly  4223 ----------PLSDQMPPLVPIGPVQRAG----------AAAAAAHPPPPQPPA-------ENTA 4260
                      .::|.:....|.....::|          |.|.|...|...||:       |..:
  Fly  1848 SSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLS 1912

  Fly  4261 TATEIGDGLAANIEEQASPASGNP-----ASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKN 4320
            .||.:|.|........:...||:.     |...||||:.::     |....:.|::..|:.:..:
  Fly  1913 RATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKS-----SFLASLNPARWGRQTHQNH 1972

  Fly  4321 F-----SQLQ---------------------LVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASS 4359
            .     ||.|                     |...|..|..|:..|..|.|.:..::      |.
  Fly  1973 HHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASI------SK 2031

  Fly  4360 AIFIQYLTAAILGLAEEVRQAI-QMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYV----- 4418
            :|....|.||  ...|..||.: :..::.::.|...:   ...|:|||.|||..:.:|.|     
  Fly  2032 SISHANLLAA--ANRERARQWVREQAVDFVKRYTEQE---AKRSKAASESGATQSGSSGVGLSST 2091

  Fly  4419 -----PTVSGASLLPNLAV----------------------------------HEGI---MQDRF 4441
                 .|....::|..|:.                                  |.|:   |.:..
  Fly  2092 GNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKAMLNYM 2156

  Fly  4442 TAE--------------HVIISAP-----KNA--KPT---------------CELQL-------- 4462
            |:|              ||....|     :|.  .||               |..||        
  Fly  2157 TSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVH 2221

  Fly  4463 --PSMKKLMSNSSAQPYF-----------------LR-----TLKI----FMQVRDMYEAQNGLS 4499
              |:.....||.||..:|                 ||     |:||    .:|..:.|....|. 
  Fly  2222 DFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGY- 2285

  Fly  4500 TGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISP-----------------PPPME 4547
              ||:   ..|:|||             |..||....|:.:..                 |..|.
  Fly  2286 --GGI---RADSDDD-------------SEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMT 2332

  Fly  4548 TNQIAQD----GDDDEEDDDEARSFPG-------------------VGNHAVASASKSTKPTLSQ 4589
            ..|..:.    ..:..|.|:|:.:..|                   |.:.|.|.|:.|:....|.
  Fly  2333 VYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSG 2397

  Fly  4590 I-----------LCLDV----------------------------------LWN------TLSEC 4603
            :           .|::.                                  ||:      .:|..
  Fly  2398 VQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISAL 2462

  Fly  4604 LVALEESKDEFAVLVLQPTVEAFFL---IHASHRGASKKSG----RSFMPNAAGFGLRAAAGAG- 4660
            ...|..|.....|.|...:::|..:   |||.:|......|    ::.:|.:.....:..|.|. 
  Fly  2463 KPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANR 2527

  Fly  4661 --------AIGGLGAAAPSAQEYSPFMDDVSSANTPSSA-SFDDEPRMQDASTNTPLVTNPSTST 4716
                    ..|.|....|......||:....:.:....| |||     :|.:....|.|.|..:.
  Fly  2528 QLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFD-----RDRALQRLLDTTPDLNA 2587

  Fly  4717 AMSAHEAQLRQDRQK-------FLQFAEK------HRTVLNQILRQSPTHLSDGP---FAVLVDH 4765
            |.|:.....|.||:|       .|:.||.      |...|.:|..::......||   |..||  
  Fly  2588 AESSERVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALV-- 2650

  Fly  4766 TRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTV------------FEDSFRVL------- 4811
                         ..||:|.|.|:.....:.....||:            .||:....       
  Fly  2651 -------------SAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTP 2702

  Fly  4812 ---------------------YRLGPEEWKNRFYIVFE-------DEEGQDAGGLLREWYVIISR 4848
                                 ::..|....:|.:::..       :.....||.......::|::
  Fly  2703 AVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQ 2767

  Fly  4849 E-----------IFNPMYALFCVSPGDRVTYMINPSSHANPNHLSY------------------- 4883
            :           |.||.......:.....|...|.|........||                   
  Fly  2768 QFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLP 2832

  Fly  4884 --------FKFVGRVIAKAVHDNKLLECYFTRSFYK------HILG--------KQVKHTDMESQ 4926
                    |||:|:.:||||.|:::|:..|:..||:      |.:|        .:|::|.:..|
  Fly  2833 QMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQ 2897

  Fly  4927 DYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLK--------------PNGRDTAVTE 4977
            |  ..:..:|:: :|.:....|.|...|..:.....|.||.              ..||||.||.
  Fly  2898 D--LVRQREYIL-SDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTV 2959

  Fly  4978 ENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLP--------DI 5034
            .|..:|:.||....:...:::|.:|..|||..:.|...:.:|..:|||.:..|..        :|
  Fly  2960 HNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEI 3024

  Fly  5035 DIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQK 5099
            .:......|: |.:...|..||:.:..|.|:::.::..|||||||:.::|..||.:|.....|.:
  Fly  3025 KMLQESCRTD-HGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVR 3088

  Fly  5100 FQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            ..:..:....|.||...||.|.|.||.|.|.:.:|..|..|.:|.|..|
  Fly  3089 KTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSF 3137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 6/75 (8%)
DUF4414 3675..3779 CDD:291075 21/113 (19%)
HECTc 4796..5149 CDD:238033 102/474 (22%)
HECTc 4820..5148 CDD:214523 96/408 (24%)
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669 7/50 (14%)
WWE 1409..1481 CDD:128922 15/74 (20%)
FAM199X <1985..2074 CDD:292442 18/99 (18%)
HECTc <2818..3138 CDD:294058 85/324 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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