Protein Alignment HUWE1 and Nedd4

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Alignment Length: 1189
• Identity: 311/1189 - (26%)
• Similarity: 466/1189 - (39%)
• Gaps: 259/1189 - (21%)

  Fly  4026 LSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDV---PPGGTLDFRSRFCRYQVVNRLRSIFDDH 4087
            |.|...:|.|:        |.|:.:||     ||   ||      |.|........:.|..|.:.
  Fly     8 LVAAAALPVPS--------SSSSVAGG-----DVPRPPP------RRRAASVAGQQQTRQEFGNG 53

  Fly  4088 PAPKPSVPL--DEAPSTS-KAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNIDQ---Q 4146
            ..|:.|:..  |...|.. :.......:.||....|:    |.||.....|..:..:|||.   :
  Fly    54 YTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGA----SDPYVRIDLNTINGDINIDSVLTK 114

  Fly  4147 TQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASL 4211
            |:.:..|         |.|     ..:|: |...|..   ..|.::|...:....|..:.::...
  Fly   115 TKKKTLN---------PTW-----NEEFI-FRVKPSE---HKLVFQVFDENRLTRDDFLGMVELT 161

  Fly  4212 STELPKEEELLPLSDQMPPLVP---IGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANI 4273
            ...||.|:|...:.:|...|.|   :|...|........|                   ......
  Fly   162 LVNLPTEQEGRTIGEQSYTLRPRRSVGAKSRIKGTLRIYH-------------------AFIRET 207

  Fly  4274 EEQASPASGNPASGD------SNAGAKRTQ---LPTLS-VALPVTPSKPRRKIYSKNFSQLQLVI 4328
            .||:.|:||| :.|:      :|||....|   .||.. .||| ...:.|:....:.:
  Fly   208 REQSEPSSGN-SDGEWEHVEATNAGETSAQPHPFPTGGHDALP-AGWEERQDANGRTY------- 263

  Fly  4329 EVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNI 4393
             .:.|...||: .|....|..:.:|.:....|...|......:...|..|.|..:..|.|...|
  Fly   264 -YVNHTARTTQ-WDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNN- 325

  Fly  4394 HQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRF-TAEHVIISAPKNAKPT 4457
            :..|...|.:.|:||.|...|    || :...:|..:|:.....:|:. |.:|..........|.
  Fly   326 NAAGLAYTPKTAATSSAPPNT----PT-NNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPV 385

  Fly  4458 CELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLS--TGGGVACGAG----------- 4509
            ...|.......:.|.      ||.::....|.|: ...|..:  ..|.:|.|||
  Fly   386 AHRQPEISATSLQND------LRPVREAPGVPDI-AITNPFTRRAAGNMAGGAGWQQERRRQQMQ 443

  Fly  4510 -------------DNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQ------DG 4555
                         ..:..::|::.                    ....|....|..|      :.
  Fly   444 LHIQQHQQRQQQQQQNRILLDVDH--------------------RQQEPQHRGQRHQQQHRPSNE 488

  Fly  4556 DDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQ 4620
            |.|..|...............:....:..|.:.|        ||..|     ||.......:.:.
  Fly   489 DTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQ--------NTGGE-----EEPLPPRWSMQVA 540

  Fly  4621 PTVEAFFLIHASHRGA--SKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVS 4683
            |....||:.|||.|..  ..::||                         |:|...:.....||:.
  Fly   541 PNGRTFFIDHASRRTTWIDPRNGR-------------------------ASPMPNQTRRVEDDLG 580

  Fly  4684 SANTPSSASFDDEPRMQ------DASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTV 4742
                |....:::.....      |.:|.|....:|..|....|.:|
  Fly   581 ----PLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQA------------------- 622

  Fly  4743 LNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDS 4807
                                |.::|  |:..|.:||::.:.:......:.|  :.:||.::.|||
  Fly   623 --------------------VPYSR--DYKQKYEYFKSHIRKPTNVPNKFE--IRIRRTSILEDS 663

  Fly  4808 FRVLYRLGPEE-WKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMIN 4871
            :|::..:...: .|.:.::.||.|.|.|.|||.|||:.::|:|:|||.|.||..|..|..|..||
  Fly   664 YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQIN 728

  Fly  4872 PSSH-ANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLD 4935
            ..|. .|..|||||||:||:...||:..|||:.:|.|.|||.:|.|.:...||||.|.|:|..|.
  Fly   729 NGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLM 793

  Fly  4936 YLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQL 5000
            ::.:||...|  ||||..:...||.....:|||.|.:..||.|||.||::||.:.:....:::|:
  Fly   794 WIKENDPRIL--ELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQM 856

  Fly  5001 DAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRS 5064
            .:||:||..|||.:||.||:|.|||||:.|:.:||::|.:.||.|. .|......|||||||:.|
  Fly   857 SSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLS 921

  Fly  5065 FDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKS 5129
            |....|::.||||||||:||:.||..|.|.||.|.|.|.:.. :.:..|.||||||:||||.|:.
  Fly   922 FSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWG-TPNNFPRAHTCFNRLDLPPYEG 985

  Fly  5130 YDKLRSCLLKAIHECSEGF 5148
            |.:|:..|:||| |.|:||
  Fly   986 YLQLKDKLIKAI-EGSQGF 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	161/356 (45%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	30/173 (17%)
		WW	248..277	CDD:459800	7/38 (18%)
		HUL4	<523..1003	CDD:227354	192/560 (34%)