DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and ube3c

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_956767.2	Gene:	ube3c / 393445	ZFINID:	ZDB-GENE-040426-1211	Length:	1081	Species:	Danio rerio

Alignment Length:	439	Identity:	133/439 - (30%)
Similarity:	212/439 - (48%)	Gaps:	65/439 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  4737 EKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQ-----TELERLDEGIRREEHTV 4796
            |:|..:|.::           ||        ::.|:.:.|.||     .:.|...||...:...|
Zfish   678 ERHLAILTEL-----------PF--------VVPFEERVKIFQKLIYADKREVQGEGPFLDGVNV 723

  Fly  4797 SVRRVTVFEDSFRVLYRLGPE---EWKNRFYIVF-----EDEEGQDAGGLLREWYVIISREIFNP 4853
            ::||..::||::.   :|.||   :.|.|..:..     .||.|.|.||:.||:...:.:..|||
Zfish   724 TIRRNYIYEDAYD---KLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNP 785

  Fly  4854 MYALF-CVSPGDRVTYMINPSSHA----NPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHI 4913
            ....| ..:.|     ::.||..|    ..:...::.|:||::.||:::|.|:|..|...|...:
Zfish   786 NQGFFKTTNEG-----LLYPSPTAEMLVGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKL 845

  Fly  4914 LGK----QVKHTDMESQDYEFYKGLDYL--MKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRD 4972
            ||.    .:.|  :.|.|.|.|:.|.:|  .:.|:..||  |.|:....:.|..|:.:|||.|:|
Zfish   846 LGTSADVDIHH--LASLDPEMYRNLLFLKSYEGDVEDLG--LNFTVVNNDLGEAQVVELKPGGKD 906

  Fly  4973 TAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISG--LPDID 5035
            ..||..|:..|:.||...:::..||....||.:|..:::....:.:|::||:::|:||  :| |.
Zfish   907 IPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLVSGAHVP-IC 970

  Fly  5036 IEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQK 5099
            :||||..|.|. .|::....|:.||..:.||...::.|.|:|||..|:.||.||..|     ...
Zfish   971 LEDLKRFTNYSGGYSATHPVIKIFWDVVESFSDEEKRKLLKFVTSCSRPPLLGFKEL-----YPA 1030

  Fly  5100 FQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            |.||......:|||.|.||.|.|.||.:.....:|:.||.|| |.|.||
Zfish  1031 FCIHNGGTDLERLPTASTCMNLLKLPEFCDPQLMRNKLLYAI-ESSAGF 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	121/375 (32%)
		HECTc	4820..5148	CDD:214523	111/346 (32%)
ube3c	NP_956767.2	IQ	47..64	CDD:197470
		HECTc	723..1079	CDD:238033	121/375 (32%)
		HECTc	745..1078	CDD:214523	111/348 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910