DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and Herc4

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster


Alignment Length:1084 Identity:234/1084 - (21%)
Similarity:392/1084 - (36%) Gaps:334/1084 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  4315 KIY---SKNFSQL----------------------QLVIEVLTHQCGTTEGL------------D 4342
            |:|   |.::|||                      .::|::.   ||:...|            |
  Fly    60 KVYACGSNDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQIC---CGSRHSLALSDWGQVLSWGD 121

  Fly  4343 NVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIH-----------QG 4396
            |         .|.|...|     ....|:.|.:.|||.:...:.:|...|.|           ..
  Fly   122 N---------DCGQLGHA-----TDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSW 172

  Fly  4397 GAGTTSQAASTSGAAAATASY---VPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNA---- 4454
            |:....|....|.......:|   :.|:.|   :|..|:..|       ..|..:.:...|    
  Fly   173 GSNIYGQLGVNSPNDLTHCNYPLRLTTLLG---IPLAAIACG-------GNHSFLISKSGAVFGW 227

  Fly  4455 -KPTCELQLPSMKKLMSNSSAQPYFLRTLKI-FMQVRDMYEAQNGLSTGGGV-ACGAG------- 4509
             :..|. ||....:...:...|...||||.: |:...|.:..  .|:..||| .||||       
  Fly   228 GRNNCG-QLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSV--FLTNEGGVFTCGAGAYGQLGH 289

  Fly  4510 ---DNDD------------------------DIIDIEGDGGASG-GSSSDMAPGSASTISPPPPM 4546
               .|:.                        .::...|...|.| |||..:...|..::..|..:
  Fly   290 GFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVV 354

  Fly  4547 ETNQIAQDGDDDEEDDDEARS------FPGVGNHAVASAS-----------KSTKPTLSQILCLD 4594
            ....::..|....:.:|...|      |.| |:.::.:.:           ::..|. ||||.|.
  Fly   355 IGPWVSPSGSALLQSNDSQVSLVIRQIFSG-GDQSIVTTTLFVDKVPPEDFRNYNPK-SQILTLT 417

  Fly  4595 V-LWNTLSECLVALEESKDEFAVLVLQPTVEA-----FFLIHASHRGASKKSGRSFMPNAAGFGL 4653
            . :....::|...|:...|..:.:.|....:|     |.|.|..|.|.|.::        .|..|
  Fly   418 AEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRN--------HGLDL 474

  Fly  4654 RAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPS--SASFDDEPRMQDASTNTPLVTNPSTST 4716
            :||..|                   .|::.:....|  ...:|:..:....|    ||.:|:...
  Fly   475 KAAQLA-------------------FDNLRAVENESIRQVIWDNITKELVGS----LVCSPADVE 516

  Fly  4717 AMSA-------HEAQLRQDRQKFLQ---------FAEKHRTVLNQILRQSPT----HLSDGPFAV 4761
            :|..       ||. :.....|.||         .||..|.|||:.|.|:|.    ||......|
  Fly   517 SMRLYLLLPLYHEF-VNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHV 580

  Fly  4762 LVD---------------------------------------------HTR----------ILDF 4771
            ::.                                             |.|          :.|:
  Fly   581 VIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDY 645

  Fly  4772 -DVKRKYF------------------------QTELERLDEGIRREEH----------------- 4794
             ||:::|.                        :|.|.:.|:.::....                 
  Fly   646 ADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMP 710

  Fly  4795 -----TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPM 4854
                 .::|.|..:.:||.|.|......:.|....|.|..||.:||||:.:|:::::.:::.:|.
  Fly   711 ISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPK 775

  Fly  4855 YALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVK 4919
            |.:|......|:.:..:.:.....   .|| .:|.:...|:::..::...|..:.:|.:|||.|.
  Fly   776 YGMFKEYEQSRLLWFADLTFETEN---MYF-LIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVD 836

  Fly  4920 HTDMES---------QDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAV 4975
            .:|:..         |....|:|.|:   .::    ::|||......||..:.:.|||||.:.||
  Fly   837 LSDLRQLSPPEANSMQSLLDYQGDDF---KEV----FDLTFEISRDVFGEAETKCLKPNGNEIAV 894

  Fly  4976 TEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLK 5040
            |.||:.|:|.|......:.|:....:||.:||..:....:|.||..:||..::.|..|.|.:.|:
  Fly   895 TLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQ 959

  Fly  5041 ANTEYHK-YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHR 5104
            .|.||.: |||....|:|||..:....:|::..||.|:||:.::|:||..:|:     ...|...
  Fly   960 DNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALK-----LTIQPTP 1019

  Fly  5105 DDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            |:|.   ||.||||||.||||.||:.::|:..||:||.: ::||
  Fly  1020 DERF---LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQ-TQGF 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 111/363 (31%)
HECTc 4820..5148 CDD:214523 103/337 (31%)
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826 10/52 (19%)
RCC1 114..163 CDD:278826 13/62 (21%)
RCC1 167..218 CDD:278826 10/60 (17%)
RCC1 221..270 CDD:278826 11/51 (22%)
RCC1 273..322 CDD:278826 8/48 (17%)
RCC1_2 309..339 CDD:290274 6/29 (21%)
RCC1 327..390 CDD:278826 14/63 (22%)
HECTc 715..1060 CDD:238033 111/365 (30%)
HECTc 739..1059 CDD:214523 103/339 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446936
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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