DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and CG3356

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_611896.1 Gene:CG3356 / 37876 FlyBaseID:FBgn0034989 Length:1122 Species:Drosophila melanogaster


Alignment Length:757 Identity:190/757 - (25%)
Similarity:306/757 - (40%) Gaps:190/757 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  4553 QDGDDD-EEDDDEARSFPG---VGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDE 4613
            :||||| ||.:||....|.   :......:...|.:.::.:..||      |....:..|..:.:
  Fly   394 RDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECL------LESIAILNETERVD 452

  Fly  4614 FAVLVLQPTVEAFFLIHA------------SHRGASKK--SGRSFMP---NAAGFGLRAAAGAGA 4661
            |.|..|.|.:|...||:|            .|.....|  ...:|.|   .|..|.|  ||.:..
  Fly   453 FIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFKL--AAESTQ 515

  Fly  4662 IG-----------------GLGAAAPSAQEYS-------PFMDDV------------SSAN---- 4686
            :|                 |:....|....:.       |.:.||            |:.|    
  Fly   516 LGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRL 580

  Fly  4687 TPSSAS--FDDEPRMQDASTNTPLVTNPSTSTAMS----------AHEAQLRQDRQKFLQFAEKH 4739
            .|.|.:  ......::|.|.....:..|.|.:.::          |.:.:||..:|.:.......
  Fly   581 MPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVV 645

  Fly  4740 RTVLNQI----LR------------------QSPTHL---------SDGPFAVLVDHTR------ 4767
            ..|||||    ||                  ..||.|         ...||..:.|.||      
  Fly   646 VFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENG 710

  Fly  4768 -------------------ILDFDVKRKYFQTELE--------RLDEGIRREEHTVSVRRVTVFE 4805
                               ::.|:.:....|:.:.        .:...::.....::|||..::|
  Fly   711 PPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYE 775

  Fly  4806 DSFRVLYRLGPEEWKNRFYIVFE-----DEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDR 4865
            |::..|......:.:.:|.|.|.     ||.|.|.||:.||:...:.:..|:|....|.|:..::
  Fly   776 DAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNK 840

  Fly  4866 VTYMINPSSHANPN-------HLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDM 4923
            :        :.|||       :..::.|:||::.|::::|.|:|......|...:.|   |::|:
  Fly   841 L--------YPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAG---KYSDV 894

  Fly  4924 E-----SQDYEFYKGLDYL--MKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKF 4981
            :     |.|.|.|:.|.||  ...|:|.|  .|.|:......|.|||.:|||.|:...||..|:.
  Fly   895 DIHQLASLDPELYRNLLYLKDYSGDVSEL--NLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRI 957

  Fly  4982 EYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISG--LPDIDIEDLKANTE 5044
            ||:||:...|::..||:..:||.:|..:::|...:.:|:.:||::||||  :| ||:||||.:.|
  Fly   958 EYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIP-IDLEDLKKHCE 1021

  Fly  5045 Y-HKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRS 5108
            | .:::.:...|..||..|..||...|.:.|:|||..|:.||.||..|:....||      :...
  Fly  1022 YGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQ------NTGD 1080

  Fly  5109 TDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGF 5150
            .:|||.|.||.|.|.||.:|:.:::|..||.||   ..|.||
  Fly  1081 MERLPTASTCTNLLKLPPFKTVEQMREKLLYAI---QSGAGF 1119

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 121/374 (32%)
HECTc 4820..5148 CDD:214523 114/349 (33%)
CG3356NP_611896.1 HECTc 766..1120 CDD:238033 123/377 (33%)
HECTc 788..1119 CDD:214523 115/353 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446974
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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