Protein Alignment HUWE1 and CG3356

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_611896.1
• Gene: CG3356 / 37876
• FlyBaseID: FBgn0034989
• Length: 1122
• Species: Drosophila melanogaster
• Alignment Length: 757
• Identity: 190/757 - (25%)
• Similarity: 306/757 - (40%)
• Gaps: 190/757 - (25%)

  Fly  4553 QDGDDD-EEDDDEARSFPG---VGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDE 4613
            :||||| ||.:||....|.   :......:...|.:.::.:..||      |....:..|..:.:
  Fly   394 RDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECL------LESIAILNETERVD 452

  Fly  4614 FAVLVLQPTVEAFFLIHA------------SHRGASKK--SGRSFMP---NAAGFGLRAAAGAGA 4661
            |.|..|.|.:|...||:|            .|.....|  ...:|.|   .|..|.|  ||.:..
  Fly   453 FIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFKL--AAESTQ 515

  Fly  4662 IG-----------------GLGAAAPSAQEYS-------PFMDDV------------SSAN---- 4686
            :|                 |:....|....:.       |.:.||            |:.|
  Fly   516 LGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRL 580

  Fly  4687 TPSSAS--FDDEPRMQDASTNTPLVTNPSTSTAMS----------AHEAQLRQDRQKFLQFAEKH 4739
            .|.|.:  ......::|.|.....:..|.|.:.::          |.:.:||..:|.:.......
  Fly   581 MPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVV 645

  Fly  4740 RTVLNQI----LR------------------QSPTHL---------SDGPFAVLVDHTR------ 4767
            ..|||||    ||                  ..||.|         ...||..:.|.||
  Fly   646 VFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENG 710

  Fly  4768 -------------------ILDFDVKRKYFQTELE--------RLDEGIRREEHTVSVRRVTVFE 4805
                               ::.|:.:....|:.:.        .:...::.....::|||..::|
  Fly   711 PPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYE 775

  Fly  4806 DSFRVLYRLGPEEWKNRFYIVFE-----DEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDR 4865
            |::..|......:.:.:|.|.|.     ||.|.|.||:.||:...:.:..|:|....|.|:..::
  Fly   776 DAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNK 840

  Fly  4866 VTYMINPSSHANPN-------HLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDM 4923
            :        :.|||       :..::.|:||::.|::::|.|:|......|...:.|   |::|:
  Fly   841 L--------YPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAG---KYSDV 894

  Fly  4924 E-----SQDYEFYKGLDYL--MKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKF 4981
            :     |.|.|.|:.|.||  ...|:|.|  .|.|:......|.|||.:|||.|:...||..|:.
  Fly   895 DIHQLASLDPELYRNLLYLKDYSGDVSEL--NLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRI 957

  Fly  4982 EYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISG--LPDIDIEDLKANTE 5044
            ||:||:...|::..||:..:||.:|..:::|...:.:|:.:||::||||  :| ||:||||.:.|
  Fly   958 EYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIP-IDLEDLKKHCE 1021

  Fly  5045 Y-HKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRS 5108
            | .:::.:...|..||..|..||...|.:.|:|||..|:.||.||..|:....||      :...
  Fly  1022 YGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQ------NTGD 1080

  Fly  5109 TDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGF 5150
            .:|||.|.||.|.|.||.:|:.:::|..||.||   ..|.||
  Fly  1081 MERLPTASTCTNLLKLPPFKTVEQMREKLLYAI---QSGAGF 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	121/374 (32%)
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	123/377 (33%)