DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and yki

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	439	Identity:	84/439 - (19%)
Similarity:	153/439 - (34%)	Gaps:	127/439 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  3276 SASSATSATGNGATSDATTTTGGPTRNF-----SSVDSNVSSETQTTTRPPRQRGGLRQQSQLPF 3335
            ||||.|::.......|....:...:.|.     ...|.|:.:...:...|    |..::..|||.
  Fly    29 SASSNTNSLIEKEIDDEDMLSPIKSNNLVVRVNQDTDDNLQALFDSVLNP----GDAKRPLQLPL 89

  Fly  3336 NIYAEIDLTNE-------QDSEGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVP 3393
            .:.   .|.|.       ..|..:.:.||.      .|.|||..|..:.|:.|..|..|  .|:.
  Fly    90 RMR---KLPNSFFTPPAPSHSRANSADSTY------DAGSQSSINIGNKASIVQQPDGQ--SPIA 143

  Fly  3394 LLPS-SGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSAL-----INAR---- 3448
            .:|. ..:||..|:||                      :.|.:.:|:|.::|     :.||
  Fly   144 AIPQLQIQPSPQHSRL----------------------AIHHSRARSSPASLQQNYNVRARSDAA 186

  Fly  3449 ----PNRDLPACLQRHDHPAGSIFPRPSANRTP--APTLVSMPTPMSNAALEQ-LNVTAPDVVRT 3506
                ||.: |:..|:   |||..||..||...|  ||...::.....|..:.| :.::...|.:.
  Fly   187 AANNPNAN-PSSQQQ---PAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSMQTVHKK 247

  Fly  3507 DRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVS 3571
            .|::.:.|.::::..:  |.:....::|:..|.|:..       .:.||.....||
  Fly   248 QRSYDVISPIQLNRQL--GALPPGWEQAKTNDGQIYY-------LNHTTKSTQWED--------- 294

  Fly  3572 AGTREESSAPAVATES------TEAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAAVDAS 3630
                     |.:....      .|.:.:::..:.|.:::.||..|...|
  Fly   295 ---------PRIQYRQQQQILMAERIKQNDVLQTTKQTTTSTIANNLGP---------------- 334

  Fly  3631 VGAQTPATTEEAASTAG----ASGTTATITDMSPEVRAALGDLEVPEGV 3675
                .|...|:|.:.:|    .:....|.:...|.:::.|..|:.|:.:
  Fly   335 ----LPDGWEQAVTESGDLYFINHIDRTTSWNDPRMQSGLSVLDCPDNL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	11/85 (13%)
		DUF4414	3675..3779	CDD:291075	0/1 (0%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	24/166 (14%)
		WW	266..295	CDD:395320	7/53 (13%)
		WW	335..364	CDD:395320	5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900