DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and Magi

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster


Alignment Length:1090 Identity:215/1090 - (19%)
Similarity:326/1090 - (29%) Gaps:400/1090 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  2882 VNAS-GDGSANRTN-PDDEVDDEDDDVDADPDGDPDVDPISGPSAAQAEAYLYERLGSGLMPTPP 2944
            :|:| .:||:.:.| ..|.|||..|               :|..||.::.     |.|.  .|..
  Fly    99 LNSSLANGSSRKFNCSRDNVDDGGD---------------AGEMAAASQT-----LSSA--GTDV 141

  Fly  2945 VGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGSGQR-----------SSTGGTTASIGA 2998
            ||     |.|      ...||...|:|..:|.....||...|           |:..|.:||...
  Fly   142 VG-----NGS------GHGNGTVTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSASRED 195

  Fly  2999 IASAALRPSSGSWMAPDFNFIRISGGDSS-MGSGPAIGGNANGGDMNVFITPSMSLERAGGAPGS 3062
            :||.:...|..|.|:....|  |||..|: :||....||.|.|               .||.|.|
  Fly   196 VASLSGTSSLNSQMSVHNQF--ISGLPSNGIGSNGVHGGAATG---------------RGGPPNS 243

  Fly  3063 ---GQTMSELLNEQPTGAGGGGGGGSASGVGGVGANGGTTGQHPN------------------AT 3106
               |...:.|.|....|..|....||..|||.|        ||.|                  .|
  Fly   244 ILKGSKENLLQNTYYNGETGDSSLGSECGVGDV--------QHQNHESHDDPGDGLGPLPPKWET 300

  Fly  3107 LCTNGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQDALHWWLEEATLLDMESQTDAC----- 3166
            ..|.  |..|.::|         |...|.            ||.....:....:|..|.|     
  Fly   301 AYTE--RGELYFID---------HNTGTS------------HWLDPRLSKYQKKSLEDCCEDELP 342

  Fly  3167 ---------LYAAHFL----------LPHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSS 3212
                     :|..:|:          .|.|..:.:||.|.::|::..:|.      .......|.
  Fly   343 YGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQ------QQMQEQRSK 401

  Fly  3213 TTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVP------PVAASATGGTRRSSIPVLISST 3271
            |        |||.|.......|.|.......|.:.:|      |....   |.|       |::|
  Fly   402 T--------PTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQ---GQR-------INTT 448

  Fly  3272 LGPSSASSATSATGNGATSDATTTTGGPTRNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPF- 3335
            |..||.....:..|:..::      ||....|..:      :|.....|....|.|:....|.: 
  Fly   449 LLKSSRGLGFTIVGSDGSA------GGDVEEFLQI------KTVVPNGPAWLDGQLQTGDVLVYV 501

  Fly  3336 --------------NIYAEIDLTNEQDS------------EGDRSTSTTTGTAADGAESQSQHNS 3374
                          ||:..| |..|:.:            ..|.:|...|..|.||.||..|...
  Fly   502 NDTCVLGYTHHDMVNIFQSI-LPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRL 565

  Fly  3375 SSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSS--GHTNSS 3437
            :...            ....|..||..:: .|....:..:|::..:....:.::||.  |.|.:.
  Fly   566 NMDG------------NYNFLDLSGEGAK-KTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIAD 617

  Fly  3438 RTSGSAL--------------------INARPNRDLP---------ACLQRHDHPAGSIFPRPSA 3473
            ...|..:                    ||....|:.|         .|.|          ..|:|
  Fly   618 SACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQ----------TTPTA 672

  Fly  3474 ---NRTPAPTLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIV--DLPQQE 3533
               .|||       |.|.:|..|.|||... :|.:..:||           |..|:.  ..|..:
  Fly   673 VKIQRTP-------PDPPANNTLAQLNQVG-NVAKLRKNF-----------VGSGLFRSKTPTAD 718

  Fly  3534 AQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPE 3598
            ......:.:||..|..|..||                 ..:|.:..:|                 
  Fly   719 LYSTQVKEVLPMRPKTPLVDT-----------------RRSRVQIQSP----------------- 749

  Fly  3599 PTPESSESTSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEVR 3663
                ::|.......|.:||..||:                    ..|.|.|.::....|      
  Fly   750 ----NNEVDDEGDGAAAAERKPLQ--------------------LQTQGKSNSSLQELD------ 784

  Fly  3664 AALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAAL 3728
                  ::|. :||                 :.::.|:.:|..:..:|...:..:...|..:..|
  Fly   785 ------DIPY-MDP-----------------YPKISRLSERLAEVTLQGDANGGIYGMPPSMQPL 825

  Fly  3729 PL-----------NIQSEVLMQQRIEQQRQAAQ--TANPEDPVDTAAFFQNLPENLRQAI---LT 3777
            ||           :.|::........|.:|||.  |.....|:.| |..||  |.:::.:   |:
  Fly   826 PLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQT-AHLQN--ERIQRRVNELLS 887

  Fly  3778 DMEESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQ 3827
            |......|:|.|     .|.::.....||||.:|....::.....:.||:
  Fly   888 DRRRVGFANLDP-----PQQMQHSPSWRNGALLDVSEDADQCELTEVTLE 932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 11/75 (15%)
DUF4414 3675..3779 CDD:291075 22/119 (18%)
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
MagiNP_001286661.1 WW 294..323 CDD:278809 9/51 (18%)
WW 342..372 CDD:238122 3/29 (10%)
PDZ 443..534 CDD:214570 20/110 (18%)
DegQ <455..534 CDD:223343 14/91 (15%)
PDZ_signaling 606..668 CDD:238492 11/71 (15%)
PDZ 925..1011 CDD:214570 2/8 (25%)
PDZ_signaling 1029..1110 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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