DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Smurf

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster

Alignment Length:	1047	Identity:	272/1047 - (25%)
Similarity:	404/1047 - (38%)	Gaps:	331/1047 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  4251 PPQPPAENTATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTL---------SVALP 4306
            |.||..        :|...|.:.:::.:..:||  |||..|.|..|:..|.         |..|.
  Fly   198 PRQPGV--------VGSSHATSPQQRHNTHNGN--SGDRQAPAGPTRSTTCTNLMNNGHRSRDLS 252

  Fly  4307 VTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAIL 4371
            ||.|..||.                     :||.|.:|.|
  Fly   253 VTASDERRH---------------------STEILSSVGK------------------------- 271

  Fly  4372 GLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGI 4436
                                   :..:.||..:|:|:.....::|...:..|.:|
  Fly   272 -----------------------ENTSPTTPVSATTTPGKKTSSSNSSSAGGRTL---------- 303

  Fly  4437 MQDRFTAEHVIISAPKNAKPTCELQLPS------MKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQ 4495
             :.|.|.|.   :.|.::..:..::|.|      ..|..:|..|.|....|.....|......||
  Fly   304 -EQRPTNEP---ATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQ 364

  Fly  4496 NGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMA-PGSASTISPPP--------------- 4544
            ||.::|.|....|          :....::|.:..|.| ..|.||.:.||
  Fly   365 NGSTSGNGSGQAA----------QPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPA 419

  Fly  4545 ---------------------------------PMETNQIAQDGDDDEEDDDEARSFPGVGN--- 4573
                                             |.:.:|........||.....||..|..|
  Fly   420 SVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGT 484

  Fly  4574 ---------------HAVASASKSTKPTL------------------------------------ 4587
                           .|:|:|:::.:|.|
  Fly   485 SGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRD 549

  Fly  4588 --SQILCLDVL------WNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSF 4644
              :|.|.||.:      |          |:.|        ..:...:|:.|      :.::.:..
  Fly   550 FDTQHLTLDAIGPLPSGW----------EQRK--------TASGRVYFVDH------NNRTTQFT 590

  Fly  4645 MPNAAGFGLR----------AAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEPRM 4699
            .|..:|..|:          :||.||.     .|.|||...:|            ||:....|:.
  Fly   591 DPRLSGSILQMIRRGTVPPTSAANAGT-----PAPPSATPATP------------SAAAAVPPQA 638

  Fly  4700 QDASTNTP----LVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFA 4760
            ..||..||    ..|||                         .||     |:...|..|.:|  |
  Fly   639 TPASNATPTTLTTTTNP-------------------------PHR-----IVPDLPQGLLEG--A 671

  Fly  4761 VLVDHTRILDFDVKRKYFQTELERLDEGIRREEH-TVSVRRVTVFEDSFRVLYRLGPEEWKNRFY 4824
            .|:...| .|...|.:..:|||:.:..   :..| .:.|.|..:||:|:|::.::..::.:.|..
  Fly   672 DLLPKYR-RDLVGKLRALRTELQTMQP---QSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLM 732

  Fly  4825 IVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGR 4889
            :.|:.|||.|.||:.|||..::|||:.||.|.||..|..|..|..|||.|..||:|||||.||||
  Fly   733 VKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGR 797

  Fly  4890 VIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTE 4954
            .:..||.....|:..||..|||.:|.|.:...|:|..|.:.::.|.::::::||.: .|.|||.|
  Fly   798 TLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFSVE 861

  Fly  4955 VQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIF 5019
            ...||...:.:|||.|....||||||.|||:|....:....|.||..|..:||.::||.||:..|
  Fly   862 NNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPF 926

  Fly  5020 NEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVP 5084
            :|:||||:|.|:..||:.|.:.||.....|:::.|:.|||:.:.|:....||:.||||||:|:||
  Fly   927 DERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVP 991

  Fly  5085 LQGFGSLEGMNGI---QKFQIH-RDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHE-C 5144
            ||||.:|:|..|.   :.|.|| ..|..|..||.||||||::|||.|::|..|...|.:|:.| |
  Fly   992 LQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETC 1056

  Fly  5145 SEGFGFA 5151
                |||
  Fly  1057 ----GFA 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	150/357 (42%)
		HECTc	4820..5148	CDD:214523	144/332 (43%)
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	272/1047 (26%)
		WW	514..546	CDD:197736	0/31 (0%)
		WW	562..594	CDD:197736	6/55 (11%)
		HECTc	702..1058	CDD:238033	150/360 (42%)
		HECTc	726..1058	CDD:214523	144/336 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840