Protein Alignment HUWE1 and Herc3

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001102101.1
• Gene: Herc3 / 362377
• RGDID: 1307803
• Length: 1050
• Species: Rattus norvegicus
• Alignment Length: 1029
• Identity: 216/1029 - (20%)
• Similarity: 357/1029 - (34%)
• Gaps: 312/1029 - (30%)

  Fly  4337 TTEGLDNVAKLIVNLTQ-------CSQ------ASSAIFIQY--LTAAILGLAEE---------V 4377
            |||....|.:||..|.|       |..      |:...|..:  .:...|||.:|         |
  Rat   120 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRV 184

  Fly  4378 RQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFT 4442
            |.     |..|.:..:..|||  .|.|.|.|||          |.|..:  |.|...|
  Rat   185 RS-----LEGIPLAQVAAGGA--HSFALSLSGA----------VFGWGM--NNAGQLG------- 223

  Fly  4443 AEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLK-IFMQVRDMYEA----QNGLSTGG 4502
                 :|..|:.:..|.::|                |||.| :::...:.:.|    ..|:.|.|
  Rat   224 -----LSDEKDRESPCHVKL----------------LRTQKVVYISCGEEHTAVLTKSGGVFTFG 267

  Fly  4503 GVACGAGDND---DD-----IIDIEGDG---------------GASG-------GSSSDMAPGSA 4537
            ..:||...:|   |:     ::::.|..               .:||       |:...:..|..
  Rat   268 AGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHT 332

  Fly  4538 STISPPPPMETNQIAQDGDDDEEDD--------------DEA--------RSFPGVGNHAVASA- 4579
            ..:..|.|::.:..|..|......|              |:.        .|.|.|....|..|
  Rat   333 CNVKCPSPVKGHWAAHSGQLSARADRFKYRVVKQIFSGGDQTFVLCSTYENSSPAVDFRTVNQAH 397

  Fly  4580 ---------------------SKSTKPTLSQILCLDVLWNTLSECLVALEESKDE-FAVLVLQPT 4622
                                 :.:|...:.|||.....||.     ..||:..|| |......|.
  Rat   398 YTNLINDETIAVWRQKLTEHNNANTVNGVVQILSSAACWNG-----SFLEKKIDEHFKTSPKIPG 457

  Fly  4623 VE-----AFF--LIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMD 4680
            ::     ..|  |:|:.|....::...||             .:..|..|.::.|..:....::
  Rat   458 IDLNSTRVLFEKLMHSQHSMILEQILNSF-------------ESCLIPQLSSSPPDVEAMRIYL- 508

  Fly  4681 DVSSANTPSSASFDDEPRMQDA----STNTPLV-------TNPS-----------------TSTA 4717
                       ...:.|.:||:    :...||.       ||||                 ..|.
  Rat   509 -----------ILPEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTL 562

  Fly  4718 MSAHEAQLRQDRQKF-------------LQFAEK---------------------------HRTV 4742
            ..:....|.:.|:.|             |:..||                           ....
  Rat   563 YKSAVLYLLRGRKTFLIPVLFNNYMTATLKLLEKLYKVNLKVKHVEYDKFYIPEISSLVDIQEDY 627

  Fly  4743 LNQILRQS-----PTHLSDGPFAVLVDHTRILDFDVKRKYFQTELE------------------- 4783
            |...|.||     |:.:.|.  ..|..:..|.|...|.|..||:.|
  Rat   628 LMWFLHQSGMKARPSIMQDA--VTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLL 690

  Fly  4784 RLDEGIRREEHTV-SVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIIS 4847
            .|:..:.|....| .|||..:..|:.|.|......:.|....::|:.|||.||||:.:|:::::.
  Rat   691 TLEPLLARSPFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLL 755

  Fly  4848 REIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKH 4912
            :|:.||:|.:|.......:.:.   |......| ::|..:|.....|::::.:::.:|..:.||.
  Rat   756 KELLNPIYGMFTYYQDSNLLWF---SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKK 816

  Fly  4913 ILG--------KQVKHTDMES-QDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKP 4968
            :|.        |::..|:..| |:...|.|      .||... :.|.|:...:.:||.:.:.|.|
  Rat   817 LLNVKPSLEDLKELSPTEGRSLQELLDYPG------EDIEET-FCLNFTVCRESYGVIEQKKLIP 874

  Fly  4969 NGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPD 5033
            .|...||.::|:.|:|..........|:.:...||..||..:....::.:|...||..::.|..:
  Rat   875 GGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSN 939

  Fly  5034 IDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGI 5097
            .:.|:|:....|. .|:|....::.||.....|....:.:||.|:||:.::|:.|..||:
  Rat   940 YNWEELEETAVYKGDYSSTHPTVKLFWETFHEFPLEKKKRFLLFLTGSDRIPIYGMASLQ----- 999

  Fly  5098 QKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
              ..|.......|.||.||||:|.||||.|.|.:.:::.|.:|: :..|||..|
  Rat  1000 --IVIQSTATGEDYLPVAHTCYNLLDLPKYSSKEIMKARLTQAL-DNYEGFSLA 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	96/363 (26%)
Herc3	NP_001102101.1	ATS1	3..341	CDD:444065	55/267 (21%)
		RCC1	313..377	CDD:395335	10/63 (16%)
		HECTc	702..1048	CDD:238033	96/364 (26%)