DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and Herc6

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_008761185.1 Gene:Herc6 / 362376 RGDID:1561739 Length:1027 Species:Rattus norvegicus


Alignment Length:517 Identity:117/517 - (22%)
Similarity:207/517 - (40%) Gaps:84/517 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly  4677 PFMDDVSSANT--------------PSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQ 4727
            |.|.|.|:...              .:|...::.|:|:|.|....|:     ......|||..:.
  Rat   546 PMMKDTSNLKVSLEMMKEVQKILEKTNSHLHNEVPKMEDTSNLKVLL-----EVMKEVHEANCQL 605

  Fly  4728 DRQKFL-----QFAEKHRTVLNQ---ILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELER 4784
            ....|:     .|..:...:..|   .::......:|.||        |||...|     ..|.:
  Rat   606 PENAFIMNDIFNFNTEEGIMAKQQMFFIKYYSMVFNDFPF--------ILDLPSK-----IILMK 657

  Fly  4785 LDEGIRREEHT---------------VSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQD 4834
            .|..::..:..               :.|||..:.||:.|.|.:....:.:....:.|.:|...:
  Rat   658 HDSSVKLSDEVKVAASPEKMGCPFFILKVRRSHLVEDTLRQLRQAEDFDLRKTLSVGFINEIRPE 722

  Fly  4835 AGGLLREWYVIISREIFNPMYALFCV-SPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDN 4898
            .||:..|::..|..|:.:|.|.:|.. ..|..:.:.:||....:    .||.| |.:...::::.
  Rat   723 GGGVSSEFFHCIFEEMTDPKYEMFMYPENGSNMWFPVNPKFEKS----RYFLF-GILCGLSLNNL 782

  Fly  4899 KLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTL-GYELTFSTEVQEFGVTQ 4962
            .::...|..:.||.:|.::....|::.......:.|..::..:...: ...:.||....:..|  
  Rat   783 NVINLSFPLALYKKLLEQKPSLEDLKDLSLLLGRNLQEVLNCEAGVIEELHMYFSIYWDQRDV-- 845

  Fly  4963 IRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELL 5027
              ||.|:|....|.|.||.:||........:.||:...|.|..|||.:..:..|..|..:||...
  Rat   846 --DLIPDGISVPVNETNKRDYVSKCVDYIFNISIKTIYDEFHRGFYKVCNRDSIRHFQPEELMAA 908

  Fly  5028 ISGLPDIDIEDLKANTEYHKYTSKS-AQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSL 5091
            |.|.|..|.:..:.|::|....||| ..|..||:|.......::.|||.|:||..::.::|..: 
  Rat   909 IIGNPTCDWKQFENNSKYENGYSKSHPTILLFWKAFHELTLDEKKKFLLFLTGCDRLHVKGLQN- 972

  Fly  5092 EGMNGIQKFQI-----HRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            ||:    :|:.     .||:      |.:.||.:.||||.|.:..:::..|..||:. ::||
  Rat   973 EGI----RFRCPEVFSERDN------PRSLTCHSILDLPKYSTMRRMKEALQVAINN-NKGF 1023

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 92/361 (25%)
HECTc 4820..5148 CDD:214523 83/335 (25%)
Herc6XP_008761185.1 RCC1 39..88 CDD:278826
RCC1 92..141 CDD:278826
RCC1 144..194 CDD:278826
RCC1_2 182..210 CDD:290274
RCC1_2 236..265 CDD:290274
RCC1 252..299 CDD:278826
HECTc 682..1023 CDD:238033 90/361 (25%)
HECTc 706..1023 CDD:214523 83/337 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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