DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Ube3a

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001178766.1	Gene:	Ube3a / 361585	RGDID:	1306361	Length:	868	Species:	Rattus norvegicus

Alignment Length:	952	Identity:	230/952 - (24%)
Similarity:	371/952 - (38%)	Gaps:	244/952 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  4327 VIEVLTHQCGTTEGLDNVAKLIVNLTQCSQ---ASSAIFIQYLTAAILGLAEEVRQAIQMLLNEI 4388
            :||...||  .|||..|.|        |:.   ||...|::         .:....||:.|
  Rat    30 LIERYYHQ--LTEGCGNEA--------CTNEFCASCPTFLR---------MDNNAAAIKAL---- 71

  Fly  4389 RMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVH---EGIMQDRFTAEHV---- 4446
            .:|.|:   |.......|..||::|   |:....|||....:.::   |....|..|.|.|
  Rat    72 ELYKIN---AKLCDPHPSKKGASSA---YLENSKGASNNSEIKMNKKEEFKEVDYLTEEKVYEIY 130

  Fly  4447 -----------IISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLST 4500
                       :|........:.|..:.|.:|:..::..:   |::|:...:.:|..|.:.
  Rat   131 EFCREREDYSPLIRVIGRIFSSAEALVQSFRKVKQHTKEE---LKSLQEKDEDKDEDEKEK---- 188

  Fly  4501 GGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEA 4565
               .||.|...::|          |..|||.|...|..         .|.:.:.|.||...|.:|
  Rat   189 ---AACSAAAMEED----------SEASSSRMGDSSQG---------DNNVQKLGPDDVTVDIDA 231

  Fly  4566 --RSFPG-VGNHAVASASKSTKPTLSQILCLDVLW--------NTLSECLVALEE---SKDEFAV 4616
              |.:.. :.:..:.:|..:....||..:..|:.:        |.|:..::.:|.   ...|:..
  Rat   232 IRRVYSSLLSDEKIETAFLNALVYLSPNVECDLTYHNVYTRDPNYLNLFIIVMENRNLHSPEYLE 296

  Fly  4617 LVLQPTVEAFFLIHASHRGA-----SKKSG---RSFMPN-------------------------- 4647
            :.|....:|...:..:.:|.     ||.|.   |..|..
  Rat   297 MALPLFCKAMSKLPLAAQGKLIRLWSKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAI 361

  Fly  4648 -AAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEPRMQDASTNT----- 4706
             ||...|:....|..:||                ||.:.:...    |||..:.::|..|
  Rat   362 VAASKCLKMVYYANVVGG----------------DVDTNHNEE----DDEEPIPESSELTLQELL 406

  Fly  4707 -------------PLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHL---- 4754
                         ||.|.....|.         ..|:..:.|.|.....||.:|.....:.
  Rat   407 GEERRNKKGPRVDPLETEIGVKTL---------DCRKPLISFEEFINEPLNDVLEMDKDYTFFKV 462

  Fly  4755 -SDGPFAVL--------VDHTRILDFDVK-RKYFQ---TELERLDEGIRREEH-TVSVRRVTVFE 4805
             ::..|:.:        |.....|.:|.: |.|.:   |.|..|.:|.:...: .:.|||..:.:
  Rat   463 ETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIID 527

  Fly  4806 DSFRVLYRL------GPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGD 4864
            |:   |.||      .|.:.|.:.|:.||.|:|.|.||:.:|::.::..|||||...:|......
  Rat   528 DA---LVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEAT 589

  Fly  4865 RVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYE 4929
            |: :..||||......   |..:|.|:..|:::|.:|:.:|....|:.::||:....|:......
  Rat   590 RL-FWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFCDLGDSHPI 650

  Fly  4930 FYKGLDYLMKNDISTLGYE--------LTFS-TEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQ 4985
            .|:.|..|::       ||        :||. ::...||...:.|||.||....:|.||:.|:|.
  Rat   651 LYQSLKDLLE-------YEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVS 708

  Fly  4986 LVCQLKMSGSIRQQLDAFLEGFYDIIPKHLIS-------IFNEQELELLISGLPDIDIEDLKANT 5043
            |.....::.|:.:|..||..||      |:::       :|..:|:||||.|..::|.:.|:..|
  Rat   709 LYSDYILNKSVEKQFKAFRRGF------HMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETT 767

  Fly  5044 EYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDR 5107
            ||. .||.:|..|:.||..:.||....:..||||.|||.:.|:.|.|.|       |..|.::..
  Rat   768 EYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKL-------KMIIAKNGP 825

  Fly  5108 STDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            .|:|||.:|||||.|.||.|.|.:||:..||||| ..::|||
  Rat   826 DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYAKGFG 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	122/375 (33%)
		HECTc	4820..5148	CDD:214523	113/344 (33%)
Ube3a	NP_001178766.1	AZUL	27..81	CDD:406862	19/76 (25%)
Ube3a	NP_001178766.1	HECTc	516..866	CDD:238033	122/377 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810