DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Su(dx)

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	1068	Identity:	286/1068 - (26%)
Similarity:	429/1068 - (40%)	Gaps:	303/1068 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  4255 PAENTATATEIGDGLAANIEEQASP----ASGNPASGDSNAGAKRTQL--------------PTL 4301
            ||...:...|.|.  ..|....|||    :||..|||.:|.|..:..:              |..
  Fly     8 PAGAASGGMEAGQ--TVNGAGSASPTPTSSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKPNP 70

  Fly  4302 SVALPVTPSKPRRKI----------YSKNFSQL-----QLVIEVLTHQCGTTEGLDNVAKLIVNL 4351
            .|.| :..||.:||.          :::.|:.|     .|..:||.|.....:.:  :.:.|:||
  Fly    71 YVEL-LIDSKSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAM--LGERIINL 132

  Fly  4352 TQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATAS 4416
                    |..:|:..    |..|.:...|.:.:               ||::.:..
  Fly   133 --------AHILQHYN----GRCEFLELTIDLFV---------------TSKSDNRQ-------- 162

  Fly  4417 YVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRT 4481
               |.||..    :|:..|:..|....:...::..:|..|..:...||   ::|:::|.    |:
  Fly   163 ---TKSGEL----VAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPS---VVSDAAAG----RS 213

  Fly  4482 LKIF------MQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTI 4540
            ..|:      |::|......||..|...:..|.||:                        ..||.
  Fly   214 CMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDH------------------------RRSTQ 254

  Fly  4541 SPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLV 4605
            :||...:..|.:|:      .....|...|.|.....:|....:|.      ...|...|::...
  Fly   255 APPVWEQQQQQSQN------QQQPLRMVNGSGAAVPQTAPYPQQPP------APALARPLTQVYG 307

  Fly  4606 ALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAP 4670
            ||.|:....||                           ::|         |.|..|:|..|.|.|
  Fly   308 ALPENTQPAAV---------------------------YLP---------AGGGAAVGPPGVAGP 336

  Fly  4671 SAQEYSPFMDDVSSANTP--SSASFDDEP------------------------------------ 4697
            ..::....: .||.:..|  .:...||||
  Fly   337 PIEQPGVGL-PVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPG 400

  Fly  4698 ---------RMQDASTNTPLVT--NPSTSTAM-----------------------------SAHE 4722
                     |:.....||...|  .|::...|                             :|..
  Fly   401 WEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVT 465

  Fly  4723 AQLRQDR-----------QKFLQ-------FAEKHRTVLNQILR---QSPTHLSDGPF------- 4759
            ||:.||.           :|.:|       ...|:||...:..|   |..:.:::||.
  Fly   466 AQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIR 530

  Fly  4760 ------AVLVDH-TRILDFD---------------VKRKY---FQTELER---LDEGIRREEH-T 4795
                  ...||| ||...|:               |.|.|   |:.:|.:   |.:......| .
  Fly   531 YTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIK 595

  Fly  4796 VSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCV 4860
            ::|.|.|:||||:..:.||...|.:.|.||:|..|||.|.||:.|||:.::|.|:.||||.||..
  Fly   596 ITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEY 660

  Fly  4861 SPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMES 4925
            :..:..:..|||:|:.||:||.||||:||.||.|::..:.:...||..|||.:|.|::...|:|:
  Fly   661 ANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIET 725

  Fly  4926 QDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQL 4990
            .|.|||..|.::..|:|...|.||.||.:.:..|.....:||.||....||||||.||:.|:.:.
  Fly   726 IDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEW 790

  Fly  4991 KMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQI 5055
            :|:..|.||...|||||.:::|...:..|:|:||||::.|:.|:|:||.:.||.|..|...|.|:
  Fly   791 RMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQV 855

  Fly  5056 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFN 5120
            .|||:.:|..|...||:.|||||||.:||:.||..|.|.||.|:|.|.:..:.| .||.:|||||
  Fly   856 VWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFN 919

  Fly  5121 QLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            :||||.|||||:|...|..||.| :|||
  Fly   920 RLDLPPYKSYDQLVEKLTFAIEE-TEGF 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	160/353 (45%)
		HECTc	4820..5148	CDD:214523	148/327 (45%)
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	27/169 (16%)
		WW	364..396	CDD:197736	1/31 (3%)
		WW	397..426	CDD:278809	4/28 (14%)
		WW	478..509	CDD:197736	5/30 (17%)
		WW	522..554	CDD:197736	7/31 (23%)
		HECTc	594..946	CDD:238033	158/353 (45%)
		HECTc	620..946	CDD:214523	148/327 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446986
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840