DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and CG4238

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	131/397 - (32%)
Similarity:	211/397 - (53%)	Gaps:	29/397 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  4771 FDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDA 4835
            |..|:.:|..|:.:.......|:..:.|:|..:.|.|.:.:......:|...|.:.|:.|:|.|.
  Fly   590 FKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDW 654

  Fly  4836 GGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNH--LSYFKFVGRVIAKAVHDN 4898
            |||.|||:.::...:|:....|||.. .|:...:::|:. ..|.|  |.:|:|.|:::.|.:.::
  Fly   655 GGLRREWFELVCSALFDARGGLFCTF-HDKHQALVHPNP-TRPAHLKLKHFEFAGKMVGKCLFES 717

  Fly  4899 -------KLLECYFTRSFYKHILGKQVKHTDMESQDYEFY-KGLDYLMKNDI-STLGYELTFSTE 4954
                   :|:...|:|||...::|.:|.:...|..|.:.| ..:.|::..|: :|...||.|..|
  Fly   718 ALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEE 782

  Fly  4955 VQEFGVTQIR---DLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLI 5016
            :.:....|:.   :|.|||..|.||...|.:|:..:.|.::..:::.::|:||:|...|||.:|:
  Fly   783 MYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLL 847

  Fly  5017 SIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQ----IQWFWRALRSFDQADRAKFLQFV 5077
            |||:|.|||||:.|..:..|.|.||   :|.....||:    :.|||..:.:|.|.:.|:.|||.
  Fly   848 SIFDENELELLMCGTGEYSISDFKA---HHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFT 909

  Fly  5078 TGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIH 5142
            ||.|::|..||..|.     .:|||.... :...||.||||||||.||.|:||::....||.||.
  Fly   910 TGCSQLPPGGFQELN-----PQFQITAAP-TFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAIS 968

  Fly  5143 ECSEGFG 5149
            |.|||||
  Fly   969 EGSEGFG 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	124/370 (34%)
		HECTc	4820..5148	CDD:214523	118/345 (34%)
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	124/370 (34%)
		HECTc	642..974	CDD:214523	118/342 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850