DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and HERC2

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster


Alignment Length:5939 Identity:1052/5939 - (17%)
Similarity:1676/5939 - (28%) Gaps:2381/5939 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   519 SSDGA----TGAGSIVYRAYHEHIGGAGSGAGLLDIGGARSSLSG-GSSGTSGMGAGSINRDGSA 578
            :|.||    .||||....:......|.|.|.|    |||..:.:| ||:..||.|:||    |||
  Fly     6 ASGGAGSSGQGAGSSQTASAAPVSAGVGVGGG----GGASGAAAGAGSAAGSGSGSGS----GSA 62

  Fly   579 ARPPAIMYPTNSYYARPLAERKAE-LSSQLPSSLAPKKPSCV-------------TQRAALL--K 627
            | ||:   .:...|.|||....|: |.:.|.:||.......|             :..|.||  :
  Fly    63 A-PPS---HSPDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNAR 123

  Fly   628 SMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGP---------------------- 670
            ..|::|.   .|..|:..         .|.|:......||.||                      
  Fly   124 GQLSYLG---DDGKHYCG---------AQQLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLT 176

  Fly   671 --------SLFLLATD-VVTVYVFNEP-----------SLLSSLQDLGITS-------------- 701
                    :....||| |::.:::::|           |::|.||:|.:.:              
  Fly   177 TQAAAQQAAHLSQATDMVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQL 241

  Fly   702 -------VMLKALLQKD-------------------------------VPATRE----VLGSLPN 724
                   |.||...:::                               .||.::    .|| |..
  Fly   242 FIYERYFVALKRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALG-LAR 305

  Fly   725 VFSALCLN----------------------------------ERGLFE-----FLSYDPFDKVLK 750
            |.:...||                                  |..|||     .|..:..::.:|
  Fly   306 VATHAALNFSFAFLRRAWRSGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIK 370

  Fly   751 VLLSPDYLVAMRRRRSSDPLGDTAT--------------NLGNAMDDLIKHHPYLRADATEAIVR 801
            .|    .|||:     .||:|:..|              .||.....|        |...|.:|.
  Fly   371 FL----RLVAL-----GDPMGNRCTAPLNDRHTALCLLLELGVQKGTL--------AATLECVVL 418

  Fly   802 LLNELVRLGSDPSFICWRANKESSGSGS---------------------GSGSHGGGHHVASTPS 845
            ||            :.|  .|:.:|:.:                     |:.:.||| .....|:
  Fly   419 LL------------LLW--EKDRAGNDNRDMPRKTGAPLQRILLRYQKIGATAKGGG-IAGGEPA 468

  Fly   846 PMVMVAGT---------GSASSV-------------------------LQGAADTNDSSGDDDDD 876
            |:.....|         .||:.|                         |:|...|..||      
  Fly   469 PVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLLRGGQATAASS------ 527

  Fly   877 DDEMSSASQQQQQPTTPGQGGGPSTPRTQQ---AGGVVGSGAGATGTPAAA-------------- 924
                |||.||:....     |.||..:.||   |...:.....:.|.|..:              
  Fly   528 ----SSAPQQRIYAL-----GWPSLSKDQQGFSAEPTLSWSGESAGVPTLSCRFQIKQVACCETQ 583

  Fly   925 ----SQAVKVVT----PPEREAIPLIDYILNVMKFIEAIFSNSPNGDHC--REFV---------- 969
                ||..|:.|    .||.|.:|:.:...:|  ||..       ..||  |.|:          
  Fly   584 MLILSQEGKLYTWRLAKPEAEPLPMEEVAHDV--FISI-------AGHCEGRHFLAIDSNHNAYS 639

  Fly   970 -------------LHGGLKPILQLLSLPNLPVDSPVSTTSQAVANVC------------------ 1003
                         .|....| .::.:|....|.|.....|.:.|..|                  
  Fly   640 WGTGEDHRLGHGDTHARAVP-TKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHG 703

  Fly  1004 -------KAILSQAQETKVLDVAL--KQLADIVAQLKPLIKHFTFPGGSVLLAELVCCQRLEDGF 1059
                   ..::....:..|:||||  .....:....:.|:  |.:..|..        .:|.:|.
  Fly   704 NSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLV--FAWGDGDY--------GKLGNGN 758

  Fly  1060 ANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRTILLK------RWGVNRETGVQLLQQLVQ-- 1116
            .|....|||         |..|..:.|..:....::.|.      .||.....|.||:::.||  
  Fly   759 CNGSLQPIL---------VESLPRVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGC 814

  Fly  1117 ----------------LYISLV-------------WESTILLNLC----SDEP------------ 1136
                            :.:|:.             |.......:|    |.||            
  Fly   815 SVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPT 879

  Fly  1137 --------TQHPDLIWDE-----IAAQMSAAAGTADPLTEAELSRKLERAAEFRTKYTPEEQ--- 1185
                    |....|:|.:     :..:........:| |...|.:.|...:....:.||.::   
  Fly   880 FPASGIACTSAQSLVWTQSSHQGVPRRAPFVVDLGEP-TFRLLDQLLGMCSSQDNRQTPNQESEC 943

  Fly  1186 --------FR-YIKSL-----------LAASSRLGRALAELLGTLVKLSVGSP--QTRQRRINDL 1228
                    || .:.:|           ||:.|||   |..|...::.|:.||.  :|.|......
  Fly   944 IAVACLNLFRLQLLALIANGVEPRQVGLASGSRL---LCSLKTRILGLAGGSQVLRTIQVAAQQA 1005

  Fly  1229 ISNITKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLICSVGFTGPMLFDDKRSAFH 1293
            :.:...|..|.|.|.|:.|:|:|.:.....|                |.|         .|....
  Fly  1006 LQDGWSVLLPTAAERAQTLTSLLPSEPGQAS----------------SAG---------HRFMTD 1045

  Fly  1294 LMISQFCAENGLKAFFEMFYWALSLDNVSQKFEFDQWASMEDLMQSHEDDKRDCPEGTGEFLDAW 1358
            |::|...||.||::..:   .|:.|::.|                    ...||.:|....|   
  Fly  1046 LLVSSLMAEGGLESALQ---HAIRLESSS--------------------CSADCGDGVHLPL--- 1084

  Fly  1359 LQLLEKMVNPRAMLDSPYTMSPRL--------------NYMPDSVPFEPVFY------LIHIHQ- 1402
            |||:.::::..|.| |...:||.|              :..|.:.|...:.:      |.|||| 
  Fly  1085 LQLITRLLSNNAAL-SQTRLSPTLGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQA 1148

  Fly  1403 -----------LAMQALR----------------RIWARRPIPNYGPSMFETMI----------- 1429
                       |.:|.:.                .:..|.|    |.:.|..|:           
  Fly  1149 QPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREP----GENSFGQMVGHLGRVLQADI 1209

  Fly  1430 ------------LILK-------------HLIKSHQTLLDRYHTRMKEIKF-------------- 1455
                        |:||             .|......:|||.:..:.|.:.              
  Fly  1210 SDALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGIICR 1274

  Fly  1456 ------------ENLYIRSTD------DG-----------------LNADHIKTLTDMG------ 1479
                        |..|:|..|      ||                 ..::.::::.|.|      
  Fly  1275 GGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLT 1339

  Fly  1480 --------------FMHYHVIEALRTNASLEE-----------------ATDYLL---------- 1503
                          .:.:|.:......||.||                 |...||          
  Fly  1340 AEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRLTHFSSECALAQLLGLVANLMCSG 1404

  Fly  1504 ----------------------------NNP---------EASSLSTTGGQSSSSAPPP------ 1525
                                        :||         .:.|..:|.|.:.:..|||      
  Fly  1405 PALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAGNTPTELPPPLPMQQQ 1469

  Fly  1526 -PPPPSASTMDIDVDVPADGESTQSKSSTSPNSSYDYKHLKLMPSLIFDRFCDEAISRAFEFM-- 1587
             .|....|.:.:..|....| ..:::.|..|.:::         ..:.:|:|     :|...|  
  Fly  1470 LAPGRGKSQLQLRADAFISG-LAEARVSEPPVAAW---------LALTERYC-----KAHNLMWH 1519

  Fly  1588 --EAIPDTVNSAADLIAVLYRRHNHLNKQVFVT-----------------------NFVRN---- 1623
              .|....|.....|::.:..||.:|...|...                       :.||.    
  Fly  1520 QEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQL 1584

  Fly  1624 ----------IIQWVDFTLQLFEPAKTTGSKASRLEECLT-----GMTATRLFVRLKTS------ 1667
                      |::.:.|.|....||.:...:..|....|.     .|...||...|::|      
  Fly  1585 NRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPAKP 1649

  Fly  1668 ------TLLLEENYSDLHRPLVEAITAQDAMVSLVK----------------LLDCMSQWMLEQS 1710
                  ::..|:.......|..| :..|:...:|::                |:..:..:.|:.|
  Fly  1650 EDLLNASIQQEQEKKPQSMPKQE-LEEQEEEETLLRRLNERQIHGEGELDPALMQDIVDFALQDS 1713

  Fly  1711 TETNTG-----------QQRATVPRWVQNLVDLIDAIDSISHILQR---KANMRAVSSDVWRWYD 1761
            .:..|.           |.|....:.||.|::|...:|:..:.|..   ..::::.||.     .
  Fly  1714 CDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQYSLLNGFLGLHLKSTSSG-----G 1773

  Fly  1762 ASTGKW------------NAYSEA---------------------NNE----------------- 1776
            .|||..            :||.:|                     |.|                 
  Fly  1774 GSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQGHARGKDSTNLGTYV 1838

  Fly  1777 ----------------LIRNAYAAGERWLYINIGRQRCTVSLNCMTQVSEASG--THRPVC---- 1819
                            |:.......|....||.|.....:.|...|....|:|  .|..:.    
  Fly  1839 LLKRLPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTGGEGATGGQVHGELSILYE 1903

  Fly  1820 -PALKLSEAITSLNNPVALHKVEHILNRVVRTA----------PDGSGTVHS----DELISLRQL 1869
             ..||...:...|:.| .|.|:..|..|:||.|          |.|.|.:.|    |..:.:...
  Fly  1904 DSVLKQKSSKAQLSGP-DLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWY 1967

  Fly  1870 VNFT-------DGQQPQQSENSANPSEEATSEDGPAAANSGSPPATMTTRSKTRQKSAAAA---- 1923
            ...|       :||...|..:||......|..:....:.|.:.|.:.:..||..:..||..    
  Fly  1968 TGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEASPTSDSHPSKLLRHCAAKLLQIL 2032

  Fly  1924 -------AAAKNKSQSGGSPPI------PKRTQKII------LNEEQVGLSKFDCGRIIGSIVDL 1969
                   .|..:|....|...:      ||.:...|      ||...:.....||.|:   .::|
  Fly  2033 AVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYALGWLNLGFIRAISGDCPRL---CLEL 2094

  Fly  1970 LQP---SHQML-------NETKLSLLRLCARLTRNYDNAQVFIRRGGV----RMLLHLQQACSFM 2020
            ..|   ||.:.       ||..:.....|.||      .|:.:.:.|.    ||...:.|..:.:
  Fly  2095 STPGWLSHYLSLLEQPAGNEAGVYRQLHCLRL------LQLILAQWGAEEEPRMPALVHQLFATL 2153

  Fly  2021 GFPTYANIILRHVLEAP------PVLQEAMERVLGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQ 2079
            |         |..|..|      |..:.....:|....:|.|.   .:|:.:|.::.:..|.||.
  Fly  2154 G---------RIALHCPGDASLLPTAEGKARVLLTASHSGSVA---EELVALLRRLHTLPSWNPV 2206

  Fly  2080 I--FVAAAKEMLKGEYLINTNSTTLADDARVMVKSKFGQQPTAAAGGATPHNQTP---------- 2132
            |  |: |.|..:..|.|...:.:|..|..:|.|....|     |.||   |:..|          
  Fly  2207 INSFL-AQKLCVAAELLAEQSHSTALDSEQVFVLGVLG-----AMGG---HDLRPRVGLHCFHEG 2262

  Fly  2133 --------TPP---------------------PAAKDELKDDPQVQSSVAVLKEL-LHGLVQPCW 2167
                    ||.                     ||..      |.:..:|..|..| ::.::...|
  Fly  2263 SHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVM------PHLDHTVFSLSRLPMNEMLLNAW 2321

  Fly  2168 H---YG-----------GTGSLD---------------------RGQGAAELLQPDQPPGTAQGC 2197
            .   ||           ..|.||                     |.|.|...:...:.||:.. .
  Fly  2322 TVLLYGPAPELRELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIY-A 2385

  Fly  2198 HDDELYFRFQETPAPVSSKKQSSSGGGAAAAGQTGQATEKFEPCCCTWHIPTSGHTHAKPT---- 2258
            ..||......|:..|....:|.|||        :||..:....|...      ..|.|.|.    
  Fly  2386 SPDEPDRSDAESQQPGEQDQQLSSG--------SGQEPQLLIQCILL------RATQASPVKACY 2436

  Fly  2259 ----ISRATLLKLLADSTRAYQSL-----VPRVLLSHVYTPADSPLISAPQQTFLGVLLDRFLPI 2314
                ::.|.|..:.:.:|:|:|.|     ||         |....|.|.||.|.:          
  Fly  2437 SYMDLATAALNCIQSLATQAHQELSEGGGVP---------PNGRALSSPPQPTMV---------- 2482

  Fly  2315 TQRHHVPEVSTMTRVLICSLSDCYQQPGVQVHVAEELHAAVARALAQPDSAEKHTRLQVLMSLFP 2379
               |.||         :.:::...|:|..||....:..||...|                 .|..
  Fly  2483 ---HGVP---------VYNVARKEQKPSEQVEQKSKWPAAATDA-----------------QLIG 2518

  Fly  2380 NLIESPMLYDKVHMHRNNMYRVLLRQGVMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSV 2444
            .::|.......|.:   .:.::.|:..:|....::.|:                    ||....|
  Fly  2519 QIMEMGFTRRTVEL---ALKQLSLQAEIMPTPEQIVQW--------------------ILEHPDV 2560

  Fly  2445 STTTLGSKRI-LFGSGGPGGPNASG-----NGNNTAGGSSG-----------NGPG--------- 2483
            ...|:....: |..|.....|.|..     :.|:|...|:.           :||.         
  Fly  2561 CANTIEEDTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRK 2625

  Fly  2484 ---SGNTYGTIINRRLYPRLAARTGFGSAMERSNAMG--------GEHVLRDIIRNVLSD-RRHA 2536
               :.:.|...:...:.|.:..|........:...||        |.|.|     ||..| |.|.
  Fly  2626 DFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDL-----NVQVDWRNHG 2685

  Fly  2537 ---------FEFIFNSDDMAVDSEDAAAPGSGVGGG------------------GSGAGSVGGGV 2574
                     .|.:    :.|........|...||..                  |...||...||
  Fly  2686 STYWVCFVHIELV----EAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGV 2746

  Fly  2575 SGSVSGNSSAAVIDVVEERSNGGDTNDPPANVSSASSGAGQSSTSGGPVRPVVNFDQLWDDFLQS 2639
            ..||  .|....:|..::.:..|..|:.....|..:|....|........|..:..:.|...::|
  Fly  2747 VSSV--RSKQLTVDFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRS 2809

  Fly  2640 EGLRLASRSGGGAGSGSGSVGASSSGQQNGSNTTASSTNSG------------------------ 2680
              |.::|..            |::....||||....|.:||                        
  Fly  2810 --LTVSSNE------------AAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILVHSLTLKVS 2860

  Fly  2681 ----------------------------------------------------------NNS---- 2683
                                                                      ||.    
  Fly  2861 PEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCK 2925

  Fly  2684 --GIGNLRLRTNPDVDVGSGNGSGSGSGSNAGVVNDNGISGGGGSDGASTSSDTGAPGGARDLNA 2746
              ||..:..|..||:.....|.....|..:|||       |.|.:.||                 
  Fly  2926 IHGIKFVGRRQQPDLQHILANAQFLASEYSAGV-------GPGSTAGA----------------- 2966

  Fly  2747 SLLGDVSTSESDSDPSTEND--------ERNEEDEDEDDDAPDEDVDEHSETDVDEERSRQFIEV 2803
               |.||||..::..:.|.|        ..|::::..........|...|:|          |..
  Fly  2967 ---GAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQT----------ISR 3018

  Fly  2804 FDHIYEPESSET---ASNDADVDNDDDDDEDDVDDDDDDDEDNDDDVREEVQSVMDAEIENRIDI 2865
            ...|:....|::   .|.|..|                      ....|.....:...:.:.:.:
  Fly  3019 LRPIHIAGGSKSLFIVSQDGKV----------------------YACGEGTNGRLGLGVTHNVPL 3061

  Fly  2866 ALALVSSNNRPRRSAAVNASGD----------------------GSANRTNPDDEVDDEDDDVDA 2908
            ...|........:..||::.|.                      |..|||..|            
  Fly  3062 PHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLD------------ 3114

  Fly  2909 DPDGDP------------DVDPISGPSAA---QAEAYL-----YERLGSG-----LMP---TPPV 2945
                .|            ||...|..|||   |.|.|.     |.|||.|     |.|   |...
  Fly  3115 ----KPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALA 3175

  Fly  2946 GFR---VRMNSSIAQPLDIDVNGG--NAGSGSNAGATGSSGGSG--------QRSSTGGTTASIG 2997
            |.|   |...|..||.|.:..:|.  :.|.| :.|..|..|..|        :.|..|......|
  Fly  3176 GRRVVQVACGSRDAQTLALTEDGAVFSWGDG-DFGKLGRGGSEGSDTPHEIERLSGIGVVQIECG 3239

  Fly  2998 AIASAALRPSSGSWMAPDFNFIRIS-GGDSSMGSGPAIGGNANGGDMNVFI--TPSMSLERAG-- 3057
            |..|.||..:...|.....::.|:. |||..:.....|||......::|.:  ...:::..||  
  Fly  3240 AQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQV 3304

  Fly  3058 --------GAPGSGQTMSELLNEQPTGAGGGGGGGSASGVGGVGANGGTTGQH-------PNATL 3107
                    |..|||.|   .:|::|         ....|:..|..|....|..       |||: 
  Fly  3305 YAWGDNDHGQQGSGNT---FVNKKP---------ALVIGLDAVFVNRVACGSSHSIAWGLPNAS- 3356

  Fly  3108 CTNGVRRRLLYLDQQYCVCMP--THQNPTEETQMETFTQDALHWWLEEATLLDMES-------QT 3163
                       .|::....:|  :.::|...:.:..:..:.:....:||..|:..|       :|
  Fly  3357 -----------SDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSSLSESLALET 3410

  Fly  3164 DACLYAAHFLLPHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVG---TAAPTAT 3225
            .|...||   |.|:::.:... |.|:...||..|.:..:.....|.......::|   ..||.. 
  Fly  3411 PAARQAA---LGHVLRAMSIL-QARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQ- 3470

  Fly  3226 SSIASGLLANAVSAGSGSSSLVVPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATS 3290
                   ||..::.|.|.:     |..|:..|....|           |.:|..|.:...:|..:
  Fly  3471 -------LAETIAQGGGEA-----PADATDAGLQEHS-----------PEAAVDALTGGMSGGAN 3512

  Fly  3291 DATTTTGGPTRNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRST 3355
            .....:.||...|.|                                     ||......|..|:
  Fly  3513 TLPPLSAGPLSAFQS-------------------------------------LTGSLSMSGSLSS 3540

  Fly  3356 STTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTD 3420
            |                         |:|||:                 |:|:..:.:.::..|.
  Fly  3541 S-------------------------ALPQHK-----------------HSRMSASAMSVMAATM 3563

  Fly  3421 RQIRNRLQGSSGHTNSSRTSGSALINARPNR-------DLPACLQRHDHPAGSIFPRPSANRTPA 3478
            .|....|...| |.:.....|..|  ..|..       .|..|        |...| ||.::|.|
  Fly  3564 TQQEEMLSHIS-HCHGLDDFGGLL--GEPEAKSLVELLKLAVC--------GRCGP-PSTSQTIA 3616

  Fly  3479 PTLVSM--PTPMSNAALEQLNVTAPDVVRTDRNF--ALP-------SSLEVDVDVLPGIVDLP-- 3530
            .||:|:  .||...|.|.:..:|..:.:.|.|:.  .||       |...||...:.|:|.:|  
  Fly  3617 DTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGA 3681

  Fly  3531 ---------QQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESS--APAVA 3584
                     |...:..:|.|::        .|.|           |.|::..:..|.:  ||.:.
  Fly  3682 EMLRLEFDSQCSTEKRNDPLVI--------MDGT-----------GRVLAMRSGREFAHWAPEIR 3727

  Fly  3585 T---------ESTEAVN--------ESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAAVDASVG 3632
            .         .|..:||        .:..|..|...|.|    .:|..::|:.....:.:|:.:.
  Fly  3728 VLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGS----DRAVLSQPSMALVMSLLDSRLA 3788

  Fly  3633 AQTP------ATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEV 3691
            .:.|      |:...|.|..||..|...|..:. ::.|.|...:.|...|||.     |.:.:.:
  Fly  3789 PRQPSVLLRLASALAACSQLGALTTAQRIWSLR-KLHAVLLLEQAPRPQDPSL-----STLLQPL 3847

  Fly  3692 IQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQ--TANP 3754
            |.|.||.....:...:..|.:.|....:.    ||||..::|.:..:.........:|.  ..:.
  Fly  3848 IPELLRQYEYEEPQVRGGIHLMHSDYFKT----LAALACDMQLDAALPATSSSSSSSAAPGAISS 3908

  Fly  3755 EDPVDTAAFFQNLPENLRQAILTDMEESQI--ASLPPELAAEAQFLRRDWESRNGARMDAHP--- 3814
            ...|...|:|:      |..|...:.:|.|  ..||.....|.:....:....:.:..:|:|   
  Fly  3909 TGDVHKWAWFK------RYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQ 3967

  Fly  3815 -PSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQPQHHQHTTIVHQHPHAH-HAPNMGKPLALLM 3877
             |..::....|:|.|       |::     .|..|.    ..|..:.|..| ||..: :..:.|:
  Fly  3968 SPGASMLNSTTSLSS-------STV-----SNVSPP----PGITGEQPDLHCHAHQL-ESTSTLL 4015

  Fly  3878 MEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIIS-ALISIIQKTNEDN 3941
            .||..:...|.. |.||.:|                    :..|. ||.:| ...|.|.....::
  Fly  4016 HEDHTLFQAPHD-AQLLQWL--------------------NRRPD-DWALSWGGASTIYGWGHNH 4058

  Fly  3942 ANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLA 4006
                .||.||                         .||| |..:..|..|       |.||    
  Fly  4059 ----RGQLGG-------------------------LEGS-RIKTPTPCEA-------LSLL---- 4082

  Fly  4007 KHYPSSFVPFNRDVKARRILSAVFGMPSPTA-------GSGGGAGSGSAASGGLTGYDDVPPGGT 4064
                       |.|:......::|.: :|..       ||||..|.|.:.|..:.          
  Fly  4083 -----------RPVQLAGGEQSLFAV-TPDGKLFATGYGSGGRLGVGGSDSWAIP---------- 4125

  Fly  4065 LDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPY 4129
                      .::..|:.:|                             .|.....|..||.:..
  Fly  4126 ----------TLLGSLQHVF-----------------------------VKKVAVNSGGKHCLAL 4151

  Fly  4130 QTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVI 4194
            .|..:.:                           ||            .|...|:|         
  Fly  4152 TTEGEVY---------------------------AW------------GEGEDGKL--------- 4168

  Fly  4195 CRSPHLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENT 4259
               .|...|        |.:.||..|.|            ..:..|..|..:||          :
  Fly  4169 ---GHGNRM--------SYDRPKLVEHL------------NGMSVADIACGSAH----------S 4200

  Fly  4260 ATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQL-PTLSVALPVTPSKPRRKIYSKNFSQ 4323
            |..|..|..|          ..|....|....|....|| |.|..||                  
  Fly  4201 AAITASGHVL----------TWGKGRYGRLGHGDSEDQLRPKLVEAL------------------ 4237

  Fly  4324 LQLVIEVLTHQCGTTEGL-------DNV--------AKLIVNLTQCSQASSAIFIQYLTAAILGL 4373
              |....:...||:.:..       |||        .||      ....|....:.|...::.||
  Fly  4238 --LGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKL------GRGGSDGCKLPYKIESLAGL 4294

  Fly  4374 AEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQ 4438
                                     |.......:..:.|.|.|.             ||:.....
  Fly  4295 -------------------------GVVKVECGSQFSVALTKSG-------------AVYTWGKG 4321

  Fly  4439 DRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGG- 4502
            |.....|..:...:..|....||   .||::|                           ::||. 
  Fly  4322 DFHRLGHGSVDHVRRPKKVAALQ---GKKIIS---------------------------IATGSL 4356

  Fly  4503 -GVACGA-------GDNDDDIIDIEGDG------------GASGGSSSDMAPGSASTISPPPPME 4547
             .|||..       ||||:..:   |||            ...|.....:..|||.|::    :.
  Fly  4357 HCVACSDSGEVYTWGDNDEGQL---GDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLA----LS 4414

  Fly  4548 TNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKD 4612
            |:|::          :..|..|              .|.|...|..|:....|...|:.|.    
  Fly  4415 TSQLS----------ERLRPLP--------------NPPLEYDLVRDLAPEALHARLILLH---- 4451

  Fly  4613 EFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSP 4677
            .|:.||. |.:                   :.:|.:....|.|                      
  Fly  4452 HFSELVC-PCL-------------------AMLPISGDLSLGA---------------------- 4474

  Fly  4678 FMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKF--LQFAEKHR 4740
             :.||...|...:|.        .....|.:|.:......:..:..|:::.|.:.  |...:..:
  Fly  4475 -LKDVLVYNIKEAAF--------RKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMK 4530

  Fly  4741 TVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFE 4805
            :|..|::::.|....:   |:.:.|                                        
  Fly  4531 SVFGQMVQKLPLLTQE---ALALPH---------------------------------------- 4552

  Fly  4806 DSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSP-------G 4863
               ||        ||    :.|..|...|.||...|....:..|:.|....|...:|       .
  Fly  4553 ---RV--------WK----VKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGA 4602

  Fly  4864 DRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDY 4928
            :|..::::|:. ::...::.|:|:|.::..||.....|........::.:.|:.::.||:...|.
  Fly  4603 NRDCFLLDPTL-SSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDR 4666

  Fly  4929 EFYKGLDYLMKNDIST---LGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQL 4990
            ::..||..:...|...   ...||.|||     ...:..::..:.|.|.::..|:.|||:|....
  Fly  4667 DYVAGLLCIRNMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHISPRNRAEYVRLALGF 4726

  Fly  4991 KMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQI 5055
            ::. ...:|:.|..:|...:||..|:|:|:..||:.::.|.|||.:..||:...|..:...||.:
  Fly  4727 RLH-EFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALV 4790

  Fly  5056 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFN 5120
            .|||..:..|...:|:.||:||.|.:::| :......|.:.:  .|:...:.....||.::|||.
  Fly  4791 TWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFV--LQVLEKNPPDHFLPESYTCFF 4852

  Fly  5121 QLDLPMYKSYDKLRSCLLKAIHEC 5144
            .|.:|.|.....|...|..|||.|
  Fly  4853 LLKMPRYSCKAVLLEKLKYAIHFC 4876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803 105/625 (17%)
UBA_like_SF 1467..1506 CDD:473871 10/113 (9%)
WWE 1756..1828 CDD:128922 20/144 (14%)
DUF5585 3288..3672 CDD:465521 79/437 (18%)
UBM 3670..3700 CDD:464159 9/29 (31%)
UBM 3719..3746 CDD:464159 5/26 (19%)
HECTc 4796..5149 CDD:238033 87/359 (24%)
HERC2NP_608388.2 ATS1 625..>894 CDD:444065 42/288 (15%)
Cyt-b5 1292..1364 CDD:459698 7/71 (10%)
MIB_HERC2 1928..1988 CDD:461991 13/59 (22%)
UBA_HERC2 2515..2559 CDD:270585 8/66 (12%)
Cul7 2624..2699 CDD:463286 14/83 (17%)
APC10-HERC2 2762..2932 CDD:176485 22/183 (12%)
ATS1 2987..3320 CDD:444065 74/381 (19%)
RCC1 3302..3350 CDD:395335 12/59 (20%)
ATS1 4050..4389 CDD:444065 99/628 (16%)
HECTc 4509..4880 CDD:238033 95/436 (22%)
Blue background indicates that the domain is not in the aligned region.

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