DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and CG42797

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster


Alignment Length:1822 Identity:400/1822 - (21%)
Similarity:611/1822 - (33%) Gaps:622/1822 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  3491 AALEQLNVTAPDVVRTDRNFALPSSLEVDVDVL------PGIVDLPQQEAQPEDDQLLLPPPPPP 3549
            |..|..|....|.:......||..:.:|.|.|.      |.:....|:.|:.|:.|..|.....|
  Fly    62 AFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQLGACALP 126

  Fly  3550 PPSDTTPLVHAEDDLWPGTVVSAGTRE-ESSAPAVATESTEAVNESNQPEPTPESSESTSP---- 3609
            .||:.:            ...|..||| ......::|:|.|          ||.::.:.||    
  Fly   127 QPSEAS------------LTGSKETREPRHHQTLLSTKSCE----------TPANNATLSPTNSY 169

  Fly  3610 -----------------------NPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGT 3651
                                   :||  |...|||. ||......||  |.||   .|.|...|.
  Fly   170 NGSIGSDGGSSVGGGARRKSWTLSPQ--SGGSTPLS-GAKKKTKTGA--PTTT---LSNANGDGF 226

  Fly  3652 TATITDMSPEVRAALGDLEVP-EGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHD 3715
            ...:.....|.        || |.||...:|.:..|:.||..:|                ..|.:
  Fly   227 NLWVARECFET--------VPAEMVDTLSMAEVDEEVDEEEDEE----------------AAAVE 267

  Fly  3716 SLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDME 3780
            ||:.      ||..|...:.|   ||.:||:.......|..|       |:.|            
  Fly   268 SLLG------AAAALQASAHV---QRRQQQQHHQHLRQPSPP-------QHRP------------ 304

  Fly  3781 ESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSR--------FQTTLQSLDDTRWHSS 3837
                             |.|.|            |..|:.|        ||..:...|:......
  Fly   305 -----------------LERSW------------PPRAVGRDLKLQGDVFQFDILDTDERLAEEM 340

  Fly  3838 IWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLFVEDQ 3902
            .....|.|..|.         ..|.....|.:.|.:.            |||.            
  Fly   341 AQGSGSSNNSPL---------ATPPVRFKPLLKKKIG------------PDSY------------ 372

  Fly  3903 KVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGY- 3966
             :|::...:|..:..:..||..                 ::...|.:...|..|:      |.| 
  Fly   373 -INTISTQKVPVHQSYEFPTFP-----------------SSSAVGSSSSSPNSLQ------FPYL 413

  Fly  3967 KSNIFLINRLYEGSARS--------ISINPQAAQMIVRNC-------LDLLFVLAKHYPS----- 4011
            :.:..|...|..|.|.|        :.::|:..:.....|       ||:.....:|.|:     
  Fly   414 RQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGV 478

  Fly  4012 -----SFVP-----FNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVPPGGTLD 4066
                 ..||     |:.....:|:|..|          |||||:|  |:||.||...|.|.....
  Fly   479 GGALQDAVPPGTPTFHGQRPQQRLLKRV----------GGGAGAG--ATGGATGSPLVCPPTPTH 531

  Fly  4067 FRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQT 4131
            ...|..|.|.|....|:     |...::|.| .|:.|.                     .:.|  
  Fly   532 HARRHARLQAVTANSSL-----ASGGAIPSD-PPAVSS---------------------QLDY-- 567

  Fly  4132 NAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICR 4196
                   :.|....|.|                                  ||            
  Fly   568 -------IYLQDGGQEQ----------------------------------GQ------------ 579

  Fly  4197 SPHLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTAT 4261
                               .:.:|::.:|....|.:|    :|:.|||||             |.
  Fly   580 -------------------EQSDEVVHISSTRLPSIP----ERSAAAAAA-------------AA 608

  Fly  4262 ATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPS-KPRRKIYSKNFSQLQ 4325
            |...|   ||.:|    |.:|. .||.|.|||....        |:.|: :.|...:.:.|    
  Fly   609 AAAAG---AALME----PGTGT-VSGSSGAGAAGEP--------PLPPAWEARMDSHGRIF---- 653

  Fly  4326 LVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAI--------Q 4382
                .:.|...||..               |...|.    .:....|..:..||.:        :
  Fly   654 ----YIDHTTRTTSW---------------QRPGAA----PSGGPAGREQHHRQQLDRRYQSIRR 695

  Fly  4383 MLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYV-PTV------SGASLLPNLAVHEGIMQDR 4440
            .:.||.|...::.......|.|.||:.||...|:.: |.:      ...|||........|....
  Fly   696 TITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRN 760

  Fly  4441 FTAEHVIISAPKNAKPTC--------------------ELQLPSMKKLMSNSSAQPYFL-----R 4480
            ...:|:::...::  |.|                    ..:|||..:...:.|.:.:|:     |
  Fly   761 AALKHMVMRIRRD--PPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRR 823

  Fly  4481 TLKIFM------------QVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMA 4533
            |  .||            :.|..:..|..         ..|....|::    ||.....:|..:.
  Fly   824 T--SFMDPRLPVECPRVVRHRQQHSQQQS---------SVGYYYPDLV----DGNCLSATSGHIN 873

  Fly  4534 PGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWN 4598
            ...||::|..||:...:       .......:||..|.|::.                      |
  Fly   874 ASPASSVSGVPPLPPPR-------PSSSSSSSRSSHGHGHNC----------------------N 909

  Fly  4599 TLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIG 4663
            |.|....||...:..:                                .|||.   |:|||.|.|
  Fly   910 TTSAISCALNADRSAY--------------------------------GAAGM---ASAGATAAG 939

  Fly  4664 GLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMS--------- 4719
                           .:||..|......:|..:|.:.:      ::........||         
  Fly   940 ---------------YEDVPIAYNEKVIAFLRQPNILE------ILRERQGQHTMSRQLREKINI 983

  Fly  4720 ------------AHEAQL-------RQDRQKFLQFAEKH---RTVLNQILRQSPTHLSDGPFAVL 4762
                        .|:.||       .|:...|:...|:.   ..|||..:.|.    :..||.  
  Fly   984 LRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQR----APPPFR-- 1042

  Fly  4763 VDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEE-WKNRFYIV 4826
                  .||:.|.:.|..:||....|....:..:.:||..:.||:||.:.....:: .:.|..::
  Fly  1043 ------RDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVL 1101

  Fly  4827 FEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVI 4891
            ::.|||.|.||..||::.::|||:|||.|.||..|..|..|..::|.|....|...:|:|.|||:
  Fly  1102 WDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVL 1166

  Fly  4892 AKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDIST---LGYELTFST 4953
            ..|:....||:.:|||.|||.:|...|..:|:||.|.||::.|.::..|||.|   ||  |||..
  Fly  1167 GLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLG--LTFCV 1229

  Fly  4954 EVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISI 5018
            ..:..|....|:|||.|::..:.|:||.||::.:.:.::...:::|.::.:.|||::|...|:|:
  Fly  1230 TEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSV 1294

  Fly  5019 FNEQELELLISGLPDIDIEDLKANTEYHK-YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSK 5082
            |:.:||||:|:|..:||..|.:.||||.. |......|.|||:.:..|....|.:.||||||||.
  Fly  1295 FDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSS 1359

  Fly  5083 VPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEG 5147
            :|.:||.:|.|..|.::|.|.:..: .:.||.||||||:||||.|.:.:.|...||.|:.| :..
  Fly  1360 IPYEGFSALRGSTGPRRFCIEKWGK-PNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE-TNT 1422

  Fly  5148 FG 5149
            ||
  Fly  1423 FG 1424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 24/103 (23%)
DUF4414 3675..3779 CDD:291075 22/103 (21%)
HECTc 4796..5149 CDD:238033 135/357 (38%)
HECTc 4820..5148 CDD:214523 129/331 (39%)
CG42797NP_572574.2 WW 638..667 CDD:278809 7/51 (14%)
HECTc 1068..1424 CDD:238033 135/359 (38%)
HECTc 1092..1423 CDD:214523 129/334 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446984
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11254
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

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