DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and Hecw2

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001101688.1 Gene:Hecw2 / 316395 RGDID:1593244 Length:1578 Species:Rattus norvegicus


Alignment Length:1806 Identity:401/1806 - (22%)
Similarity:636/1806 - (35%) Gaps:584/1806 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  3693 QEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAAL-PLNIQSEVLMQQRIEQQRQAAQTANPED 3756
            :|||...|.|                  ||:....| |.|:||  |..|....:..|.|.||.:.
  Rat     6 REHLLFVRRR------------------NPQMRYTLSPENLQS--LATQNSMPENMALQRANSDT 50

  Fly  3757 PVDTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGA---------RMDA 3812
            .:                :.::...|..||:......:||.|...|:.:...         .:|.
  Rat    51 DL----------------VTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDE 99

  Fly  3813 HPPSNALSRFQTTLQSLDDTRWHSSIWYDASGN--AQPQ-------HH------QHTT--IVHQH 3860
            :.|:|.   :.:..:.:..|:....:|....|.  .:|:       :|      :.||  |..::
  Rat   100 NSPANF---WDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKN 161

  Fly  3861 PHAHHAPNMG--------------KPLALLMMED-------ENILLDPDSLATLLLFLFVEDQKV 3904
            |    |..||              :.|....:.|       :.:..:||.    .|.:.::..|.
  Rat   162 P----AVMMGAEGMEGCASGSLHSRKLVSFTLSDLRAVGLKKGMFFNPDP----YLKMSIQPGKK 218

  Fly  3905 NSMRLHRVIRNLCHH-EPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEW------------- 3955
            :|      .....|| :..|..|||         |..|           |.|             
  Rat   219 SS------FPTCAHHGQERRSTIIS---------NTTN-----------PIWHREKYSFFALLTD 257

  Fly  3956 -LKLRVDAAFGYKSNI---FL------INRLYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYP 4010
             |::.:...|.....|   ||      :.||.|..|       ...||:..|       |.:..|
  Rat   258 VLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQA-------VGDQMLSYN-------LGRRLP 308

  Fly  4011 ----SSFVPFNRDVKARRILSAVFGMPSPTA-GS-------GGGAGSGSAASGGLTGYDDVPPGG 4063
                |.::.|..:|.:.....|     ||.| |:       .|..||.|.        |:..||.
  Rat   309 ADHVSGYLQFRVEVPSSAQEDA-----SPEAVGTILGVHTVNGDLGSPSD--------DEDMPGS 360

  Fly  4064 TLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVST---AGSQNKH 4125
            ..|  |..|.            :.|..:.|| .|..|..|    .:.::|.::.|   ..:.:::
  Rat   361 HHD--STICA------------NGPVSEDSV-ADGTPKHS----FRTSSTLEIDTEDLISTSSRN 406

  Fly  4126 SVP--YQTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEM 4188
            |.|  .|.:..::.|.:.:                  :.|:   :|.||   |.||.|.|...::
  Rat   407 SPPRGRQDSLNDYLDAIEH------------------NGPS---RPGTA---SSSERPMGASPKL 447

  Fly  4189 LPYKVICRSPHLTDMLVKLLASLSTE---------------LPKEEELL-----------PLSDQ 4227
                   ||...||..:..:..:.::               |.:|..|:           .|:.|
  Rat   448 -------RSSFPTDTRLNAMLHIDSDEEDHDFQQDLGYPSSLEEEGGLIMCSRTSRIDDGSLTSQ 505

  Fly  4228 MPPLVPIGPVQRAGAA----AAAAHPPPPQPPAEN----TATATEIGDGLAANIEEQAS------ 4278
            ..| ....||:...|:    |:....|...|..|:    :.||.:..:   |::|.|.|      
  Rat   506 TKP-EDDNPVENEDASVHETASLEERPENLPEVEDGSLPSGTAPDENE---ASVEPQPSADQGST 566

  Fly  4279 ----------PASGNPA-SGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLT 4332
                      |.||..| :.|::.|::|....|.|:.....||:...:....:.::.:.|.|..|
  Rat   567 ELCSSQEVDQPTSGTDAGASDTSVGSRRAASETESLDQGSEPSQVSSETEPSDPARTESVSEAST 631

  Fly  4333 HQCGTT--EGLDNVAKLIVNL------TQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIR 4389
            ...|.:  ||.|:.....|..      |:||...||.|.:  |.|.....||             
  Rat   632 RPEGESDLEGADSSCNESVTTQLSSVETRCSSLESARFPE--TPAFSSQEEE------------- 681

  Fly  4390 MYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNA 4454
                              .||.||.    ||.||.:        ||..:...|..    |.|   
  Rat   682 ------------------DGACAAE----PTSSGPT--------EGSQESVCTPG----SLP--- 709

  Fly  4455 KPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAG-----DNDDD 4514
                .:|:||.::..|.:.|     ..|....::.::::.:..|......|..|.     ..|.|
  Rat   710 ----AVQVPSREEEGSGAEA-----TALSEQGELGEVWQRRGSLEGAAAAATAAATDSQPQEDGD 765

  Fly  4515 IIDIEG--------DGGASGGSSSD------------------------MAPGSASTI------- 4540
            ..|.:|        :.||:|||.::                        :.|...:.|       
  Rat   766 PGDTQGACEGATAQEEGATGGSQTNGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIF 830

  Fly  4541 ---------------SPPPP---METNQIAQDGD------------DDEEDDDEARSFPGVGNHA 4575
                           :||.|   ..:|.|.|...            .:|..::...:..|.|..|
  Rat   831 YVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTSAIDGAGEEA 895

  Fly  4576 ---VASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFF-----LIHA- 4631
               .|||....:..|........|...|....|....|.:.|.||...|:....|     |.|. 
  Rat   896 DFHQASADFRRENVLPHSTSRSRLTLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMI 960

  Fly  4632 ------SH--------------------------RGASKK---SGRSFM---------------- 4645
                  :|                          ||...|   .|::|.                
  Rat   961 TKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLP 1025

  Fly  4646 -----PNAA-----GFGLRAAAGAGAIGGLGAAAPSAQEYSPFMD-DVSSANTPSSASFDDEPRM 4699
                 |.:|     ....:.:..||.:|     ..|.....|.:. ..|:.||.|...:.|   |
  Rat  1026 LQSSRPTSALVHRQHLTRQRSHSAGEVG-----EDSRHAGPPVLPRPASTFNTVSRPQYQD---M 1082

  Fly  4700 QDASTNTPLVT---NPSTSTAMSAHEAQLRQD---RQKFLQFAEKHRT------------VL--- 4743
            ...:.|..:|.   .|:....:...:..|.::   |:| :||.....|            |:   
  Rat  1083 VPVAYNDKIVAFLRQPNILEILQERQPDLARNHSLREK-IQFIRTEGTPGLVRLSSDADLVMLLS 1146

  Fly  4744 ---NQILRQSPTHL------------------------------SDGPFAVLVDHTRILDFDVKR 4775
               .:|:...|.|.                              :..|:.        .||:.|.
  Rat  1147 LFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYK--------RDFEAKL 1203

  Fly  4776 KYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEE-WKNRFYIVFEDEEGQDAGGLL 4839
            :.|..:||....|....:..:.:||..:.||:|..:.....:: .:|:.|:.|..|||.|..|..
  Rat  1204 RNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPS 1268

  Fly  4840 REWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECY 4904
            ||::.::|||:|||.|.||..|..|..|..|:|.|....||..:|:|.||::..|:....||:.:
  Rat  1269 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAF 1333

  Fly  4905 FTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPN 4969
            |||.|||.:|......:|:|..|.||::.|.::..|||..: .:|||:...:.||....|:|||.
  Rat  1334 FTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPG 1397

  Fly  4970 GRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDI 5034
            |.:..|||:||.||::.:.:.::...:.||.::.:.|||:::...|:|:|:.:||||:|:|..:|
  Rat  1398 GANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEI 1462

  Fly  5035 DIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQ 5098
            |:.|.:.||||. .|......|:|||.|:..|:...|.:.||||||||.:|.:||.||.|.||.:
  Rat  1463 DLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPR 1527

  Fly  5099 KFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            :|.:.:..:.| .||.||||||:||||.|.|:..|...||.|:.|.|. ||
  Rat  1528 RFCVEKWGKIT-ALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETST-FG 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075 18/86 (21%)
HECTc 4796..5149 CDD:238033 139/354 (39%)
HECTc 4820..5148 CDD:214523 134/328 (41%)
Hecw2NP_001101688.1 HECW_N 45..162 CDD:406866 20/135 (15%)
C2_NEDL1-like 185..321 CDD:176073 32/179 (18%)
MDN1 <396..741 CDD:227596 85/440 (19%)
NESP55 <464..632 CDD:115071 32/171 (19%)
WW 815..844 CDD:395320 2/28 (7%)
HECW1_helix 921..987 CDD:408233 11/65 (17%)
WW 993..1024 CDD:197736 5/30 (17%)
HECTc 1222..1576 CDD:238033 139/356 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.