DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Hectd3

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_008762291.1	Gene:	Hectd3 / 313525	RGDID:	1309823	Length:	861	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	111/466 - (23%)
Similarity:	197/466 - (42%)	Gaps:	97/466 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  4723 AQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDE 4787
            ::::|.:| ||..:.:..:::.|.||.|.:  |...|             :.|.|....|..
  Rat   437 SEIKQVKQ-FLLLSRQRPSLVTQCLRDSES--SKPSF-------------MPRLYINRRLAM--- 482

  Fly  4788 GIRREEHTVSVRRVTVFEDS-FRVLYR-LGPEE---------WKNRFYIVFEDE---EG-QDAGG 4837
                 ||.....|....::: |..:|. |.|.:         |..|:...:|.:   || .|.||
  Rat   483 -----EHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGG 542

  Fly  4838 LLREWYVIISREIFNPMYALFCVSPGD---------------------RVTYMINPSSHANPNHL 4881
            ..|:....:|.|:        |.|..|                     |..|:.|||.    ...
  Rat   543 GFRDSLADMSEEL--------CPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSC----RDF 595

  Fly  4882 SYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHT-DMESQDYEFYKGLDYLMKNDIST- 4944
            :.::::|:::..|:...:.|........:|.:.|::|..: |..:.|....|.|:.:...|..|
  Rat   596 AKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGVDKETF 660

  Fly  4945 ---LGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEG 5006
               .|.||||:|.:.:   .|:.:|.|.|....|..|::..::|||.:.::..| ::|:.|...|
  Rat   661 EFKFGKELTFTTVLSD---QQVVELIPGGTGIVVGYEDRLRFIQLVQKARLEES-KEQVAAMQAG 721

  Fly  5007 FYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRA 5071
            ...::|:.::.:...||||..:.|.|::.::.|:..|.:..:.....::|:||.||.:|...||:
  Rat   722 LLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRS 786

  Fly  5072 KFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDD---RSTDRLPCAHTCFNQLDLPMYKSYDKL 5133
            :||:||||.|::|             .:..|:.|.   .:||.||.:.||.:.|.||.|.|....
  Rat   787 RFLRFVTGRSRLP-------------ARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVC 838

  Fly  5134 RSCLLKAIHEC 5144
            ...|..|.:.|
  Rat   839 EEKLRYAAYNC 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	96/393 (24%)
		HECTc	4820..5148	CDD:214523	90/358 (25%)
Hectd3	XP_008762291.1	APC10-HECTD3	238..371	CDD:176487
Hectd3	XP_008762291.1	HECT	579..845	CDD:395507	75/286 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810