DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Wwc1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_002727807.1	Gene:	Wwc1 / 303039	RGDID:	1308329	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	840	Identity:	164/840 - (19%)
Similarity:	273/840 - (32%)	Gaps:	275/840 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  3114 RRLLYLDQQYCVCMPTHQNPTEETQMETFTQ--------DALHWWLEEATLLDMESQTDACLYAA 3170
            ||.|..|.|          ...:||.:..|:        :.|...|||||
  Rat   374 RRRLEKDLQ----------AARDTQSKALTERLKLNSKRNQLVRELEEAT--------------- 413

  Fly  3171 HFLLPHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGL--- 3232
                    :::.|.|.|.|...::.||.  :|||:..:.:||..|:..::..::||:..:.|
  Rat   414 --------RQVAALHSQLKSLSSSMQSL--SSGSSPGSLTSSRGSLAASSLDSSTSASFTDLYYD 468

  Fly  3233 --------LANAV-------SAG---SGSSSLVVPPVAA---SATGGTRRSSIPVLIS-----ST 3271
                    |.:.|       :.|   ||..:.:.....|   .|.||:|..::..|..     ::
  Rat   469 PFEQLDSELPSKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGSRLQALRSLSGTPRSMTS 533

  Fly  3272 LGPSSASSATSATGNGATSDA-------------TTTTGGPTRNFSSVDSNVSSETQTTTRPPRQ 3323
            |.|.|:.|:.|...:...:|.             ..|...||....|:.::.:.|......|..:
  Rat   534 LSPRSSLSSPSPPCSPLIADPLLAGDAFLTPLEFEDTELSPTLCELSLGTDGARERFRLEEPGPE 598

  Fly  3324 RGGLRQQSQLP----FNIYAEIDLTNEQDSEGD--------RSTSTTTGTAADGAESQSQHNSSS 3376
            ...|.|.:.:.    ..:.......:::...||        :...|:...|.|..||::   ...
  Rat   599 GKPLGQAASVAPGCGLKVACVSAAVSDESVAGDSGVYEASMQRLGTSEAAAFDSDESEA---VGV 660

  Fly  3377 TAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSG 3441
            |..|:|:...::.....:|.         .:|.....|||| .|:::..|:
  Rat   661 TQVQIALKYDEKSKQFAILV---------IQLSNLSALLLQ-QDQKVNIRV-------------- 701

  Fly  3442 SALINARPNRDLPACLQRHDHPAGSIFPRPSANRTPAPTLV---SMPTPMSNAALEQLNVTAPDV 3503
             |::   |..:...||.|         .||..:   |.:||   :....||..||.|..:.. ||
  Rat   702 -AIL---PCSESSTCLFR---------TRPLDS---ADSLVFNEAFWVSMSYPALHQKTLRV-DV 749

  Fly  3504 VRTDRNFALPSSLEVDVDV---------------LPGIVDLPQQEAQPEDDQLLLPPPPPPPPSD 3553
            ..|||:..........:.:               |.....|.:|..:|:       |...|.|..
  Rat   750 CTTDRSHTEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQGREPQ-------PAEAPGPDH 807

  Fly  3554 TTPLVHAEDDLWPGTVVSAGTREESSAPAVATEST----------EAVNESNQPEP--------- 3599
                |.|...|...|.|....|:|..:.:...|.:          |||.|..:.|.
  Rat   808 ----VDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASENEAVAEEEEREEEEGEEDVFA 868

  Fly  3600 ---TPESSE--------STSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTA 3653
               :||:.|        .|:.:...||  ||.:.|   .|..|||.:|..... .:|...|.|.:
  Rat   869 EKVSPEAEECPALKVDRETNTDSVTPS--PTVVRP---KDRRVGAPSPGPFLR-GNTIIRSKTFS 927

  Fly  3654 TITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQR---IRQRAQQNAIQIAHD 3715
            .........|....|      .|.|.|:..|..:|..:.:..:||:|   ::....:..|:.:.|
  Rat   928 PGPQSQYVCRLNRSD------SDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRTERLIRTSLD 986

  Fly  3716 SLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDME 3780
                        |.|::|:......::.|:               .:..:.|.|:|.||.....:
  Rat   987 ------------LELDLQATRTWHSQLTQE---------------ISVLKELKEHLEQAKNHGEK 1024

  Fly  3781 ESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQSLD---DTRWHSS 3837
            |     ||       |:||.|                  .||:..|:.|:   |...|.|
  Rat  1025 E-----LP-------QWLRED------------------ERFRLLLRMLEKRVDRGEHKS 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	24/105 (23%)
		DUF4414	3675..3779	CDD:291075	19/106 (18%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
Wwc1	XP_002727807.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	378..>420	CDD:299846	12/74 (16%)
		C2_Kibra	661..784	CDD:176062	31/163 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900