DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Wwp1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_006237992.1	Gene:	Wwp1 / 297930	RGDID:	1311734	Length:	968	Species:	Rattus norvegicus

Alignment Length:	994	Identity:	266/994 - (26%)
Similarity:	427/994 - (42%)	Gaps:	203/994 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  4280 ASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVL-------THQCGT 4337
            |:.:|.|..|:..:.|.||     .:.|:.:|.:||   ||:....:..||:       |.:..:
  Rat    52 ATASPRSDTSDNHSGRLQL-----KVTVSSAKLKRK---KNWFGTAIYTEVIVDGEIKKTAKSSS 108

  Fly  4338 TEGLDNVAKLIVNLTQCSQASSAIFIQY-LTA-AILGLA---------------EEVRQAIQMLL 4385
            :.......:||||:...:.....::..: |.| |:||.|               |:|::.:::.|
  Rat   109 SSNPKWDEQLIVNVAPQTTLEFRVWSHHTLKADALLGKATVDLKQVLLTHNRKLEKVKEQLKLSL 173

  Fly  4386 NEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTV-----------SGASL---LPNLAVHEGI 4436
             |.:...:..|..............|....|..|.:           :|..|   .|.|||...|
  Rat   174 -ENKNGIVQTGELTVVLDGLVIEPEAVTNRSSSPPIEIQQNGDAVHENGDPLTRTTPRLAVEGTI 237

  Fly  4437 MQDRFTAEHVII----------------SAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIF 4485
            ..|...:...::                |.|:.|  |.....|:.|.|.|..::
  Rat   238 GIDNHVSTSTVVPSSCCSHIVNGENTPSSPPQVA--TRPQNTPAPKPLTSEPTS----------- 289

  Fly  4486 MQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGS------SSDMAPGSASTISPPP 4544
                   :..||.|:                .:..|..::.|:      |:..:..:::|:..||
  Rat   290 -------DTVNGESS----------------SVLADSTSAMGTSLPSEDSTSTSNCTSTTVQEPP 331

  Fly  4545 PMETNQIAQDGD----DDEEDDDEARSF--PGVGNHAVASASKSTKPTLSQILCLDVL----WNT 4599
            ..|....::..:    ...|...||||.  |...:...:...|..:|.    .|::.|    .||
  Rat   332 VQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSGFDKVRQPE----GCVEPLRPQSGNT 392

  Fly  4600 LSECLVA-LEESKDEFAVLVLQPTVEAFFLIH-----------------------------ASHR 4634
            .:|.|.: .|:.||        |....:::.|                             ..|.
  Rat   393 NTESLPSGWEQRKD--------PHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHN 449

  Fly  4635 GASKKSGRSFMPNAAGF--------GLRAAAGAGAIGGLGAAAPSAQEYSPF------------- 4678
            ..:....|..|.:...|        .|:.|........|.:|:..|.|..|:
  Rat   450 TRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDS 514

  Fly  4679 MDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKH-RTV 4742
            .|.|...|..:..:..::||.|......||           ....::|..|:....|.:.: ||.
  Rat   515 TDRVYFVNHNTKTTQWEDPRTQGLPNEEPL-----------PEGWEIRYTREGVRYFVDHNTRTT 568

  Fly  4743 LNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQ--TELERLDEGIRREEHTVSVRRVTVFE 4805
            ..:..|...:.::.|...:..:.:    |..|..:|:  .:...|...::     ::|.|.|:||
  Rat   569 TFKDPRNGKSSVTKGGPQIAYERS----FRWKLAHFRYLCQSNALPSHVK-----INVSRQTLFE 624

  Fly  4806 DSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMI 4870
            |||:.:..|.|.:.:.|.|::|..|||.|.|||.|||:.::|.|:.||||.||..:..:.....|
  Rat   625 DSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQI 689

  Fly  4871 NPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLD 4935
            ||:|..||:|||||.|:||.||.|:...|.::..|:..|||.:|.|::...|:||.|.|||..|.
  Rat   690 NPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLI 754

  Fly  4936 YLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQL 5000
            ::..|:|...|.|:.||.:::..|.....|||..|.:..||||||.||:.|:.:.:.|..:::|.
  Rat   755 WIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQT 819

  Fly  5001 DAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSF 5065
            .|||:||.:::|...:..|:|:|||:::.|:.::|:.|.:.||.|..||..|.||.|||:.::..
  Rat   820 KAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKET 884

  Fly  5066 DQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSY 5130
            |...|.:.|||||||.::||.||..|.|.||.|||.|.:..:.| .||.:|||||:||||.||||
  Rat   885 DNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSY 948

  Fly  5131 DKLRSCLLKAIHECSEGFG 5149
            ::|:..||.||.| :||||
  Rat   949 EQLKEKLLFAIEE-TEGFG 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	155/352 (44%)
		HECTc	4820..5148	CDD:214523	144/327 (44%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988	27/131 (21%)
		PARM	243..>400	CDD:293666	32/196 (16%)
		WW	397..426	CDD:278809	6/36 (17%)
		WW	429..458	CDD:278809	1/28 (4%)
		WW	504..533	CDD:278809	3/28 (11%)
		WW	545..574	CDD:238122	5/28 (18%)
		HECTc	614..966	CDD:238033	155/358 (43%)
		HECTc	637..965	CDD:214523	144/329 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810