Protein Alignment HUWE1 and Bag3

DIOPT Version :9

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001011936.1
• Gene: Bag3 / 293524
• RGDID: 1307794
• Length: 574
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 138/639 - (21%)
• Similarity: 209/639 - (32%)
• Gaps: 181/639 - (28%)

  Fly  3196 QSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVP----------- 3249
            |:..|....:.|.|::.....|....|..|:|.|:|        .|...|.::|
  Rat    35 QTGWPFFVDHNSRTTTWNDPRVPPEGPKETASSANG--------PSRDGSRLLPAREGHPIYPQL 91

  Fly  3250 -----PVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPTRNFSSVDSN 3309
                 |:.....|...|.  |.|..:...|......|.|           ....|.|:.|.:...
  Rat    92 RPGYIPIPVHHEGSENRQ--PHLFHAYSQPGVQRFRTEA-----------AAAAPQRSQSPLRGG 143

  Fly  3310 VSSETQT-----------TTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAA 3363
            |:..|||           |.:||...|..|.||.      |..|.:         |:|::....:
  Rat   144 VTETTQTDKQCGQVPAAATAQPPTAHGPERSQSP------AASDCS---------SSSSSASLPS 193

  Fly  3364 DGAESQSQH---------------NSSSTAAQVAVPQHQR-HPPVPLLPSSGRPSRP---HTRLD 3409
            .|..|...|               |.:..|||.:..|.|: |  .|......:|.:|   ..:.|
  Rat   194 SGRSSLGSHQLPRGYIPIPVIHEQNITRPAAQPSFHQAQKTH--YPAQQGEYQPQQPVYHKIQGD 256

  Fly  3410 ETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPRPSAN 3474
            :.|...|:.|. ..|:.::|:|....|...||:.:....|.| :...:.|         |:|..:
  Rat   257 DWEPRPLRATS-PFRSPVRGASSREGSPARSGTPVHCPSPIR-VHTVVDR---------PQPMTH 310

  Fly  3475 RTPAPTLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDD 3539
            |.|.|.......|.|...|     ..||         ||          ||  .:|.|..:.|.|
  Rat   311 REPPPVTQPENKPESKPGL-----AGPD---------LP----------PG--HIPIQVIRREAD 349

  Fly  3540 QLLLPPPPPPPPS------DTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPE 3598
            ...:...||||..      .:.|:....    ||...||   ..||...||.|...|      |.
  Rat   350 SKPVSQKPPPPAEKVEVKVSSAPIPCPS----PGPAPSA---VPSSPKNVAAEPKAA------PS 401

  Fly  3599 PTP-ESSESTSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEV 3662
            |.| |::...|.:.:||...|..|:..|.::...|.:......|...|   ......|.:...:.
  Rat   402 PAPAEAASLKSGDAEAPHKHPGVLKVEAILEKVQGLEQAVDNFEGKKT---DKKYLMIEEYLTKE 463

  Fly  3663 RAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQI-AHDSLVEVNPEFLA 3726
            ..||      :.|||...|.:....|:.|    .::|.|.::.:|.||.: ....:.|:.|.
  Rat   464 LLAL------DSVDPEGRADVRQARRDGV----RKVQTILEKLEQKAIDVPGQVQVYELQPS--- 515

  Fly  3727 ALPLNIQSEVLMQQ-------------------RIEQQRQAAQTANPEDPVDTA 3761
                |::.|..:|:                   :.|.|:..|:.|.|.:|..||
  Rat   516 ----NLEPEQPLQEIMGAVAADKDKKGPENEDPQTESQQLEAKAATPPNPSSTA 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	19/76 (25%)
		DUF4414	3675..3779	CDD:291075	24/107 (22%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
Bag3	NP_001011936.1	WW	23..55	CDD:197736	4/19 (21%)
		BAG	423..500	CDD:214591	17/89 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900