DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and Nedd4l

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_038952600.1 Gene:Nedd4l / 291553 RGDID:735047 Length:1259 Species:Rattus norvegicus


Alignment Length:1561 Identity:381/1561 - (24%)
Similarity:578/1561 - (37%) Gaps:512/1561 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  3722 PEFLA---ALPLNIQSEVLMQQRIEQQRQAAQTA----NPEDPVDTAAFFQNLPENLR-----QA 3774
            |:.||   |.|....|     .:|..||:||..|    .|::..|      :.|.:.:     ||
  Rat    73 PQLLAGVDARPTRSSS-----MKISLQRKAADGATDSCGPQEGPD------DRPPSAQGDLGDQA 126

  Fly  3775 ILT-------DMEESQI---ASLPPELAAEAQFLRRDWESR---NGARMDAHPPSNALS------ 3820
            ..|       ..|.|.:   .|.||..|         |:..   ||. .|...||..|:      
  Rat   127 AATRVSAQIGSSEPSPVDTPGSSPPRAA---------WDPGTLVNGT-CDHRGPSPRLAEDTEEA 181

  Fly  3821 ----RFQTTLQSLDDTRWHSSIWYDASGNAQPQHH--QHTTIVHQHPHAHHAPNMGKPLALLMME 3879
                |.|....|. |.|....:.:...|.|:|:..  ||.      |.|  :.:.||...:..::
  Rat   182 TPGLRIQHRASSA-DVRQVRLLPFGPDGQAEPRRWSLQHV------PDA--SGSSGKRCFVFQLQ 237

  Fly  3880 DEN---ILLDPDSLATLLLFLF-----VEDQKVNSMRLHRVIRNLCHHEPTRDWIIS-------- 3928
            ..:   :.|..|       |.|     ..|:.|...|: |:.|:..:....|...:|        
  Rat   238 QPHQGTVGLGSD-------FNFGFTGTKGDRLVRYPRI-RLERSTSYPTQPRAGRVSPTEDRGTP 294

  Fly  3929 -----ALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINP 3988
                 .::..|::||.:......|.      ..|:|.|...|.:....|:.|           .|
  Rat   295 EASPRRMVPEIRRTNSERTPQSPGC------MFKIRQDQNAGQQHFRILVTR-----------GP 342

  Fly  3989 QAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGL 4053
            :.|                       |.|::               .|..|.|..|:|.......
  Rat   343 EEA-----------------------PQNQE---------------ETPKSPGHPGTGVPTRDDF 369

  Fly  4054 TGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPST---------SKAAAAK 4109
            .|..|||                ::.|       |...|::   |.|.|         |..:..|
  Rat   370 LGQVDVP----------------LSHL-------PTEDPTM---ERPYTFKDFLLRPRSHKSRVK 408

  Fly  4110 AAATAKVS---TAGSQNKHSVPYQTNAKNFWDVVLNID--QQTQVRLANVAQFPLTSQPAWE--- 4166
            .....|::   ..|.|::.:...:.:.::.|:||.:.|  .|.|..|.     |....|.||   
  Rat   409 GFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELP-----PPPLPPGWEEKV 468

  Fly  4167 -----------------W-QPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASLST 4213
                             | :|:..|..|.|::...|:.:...::......|:::.|....:....
  Rat   469 DNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGG 533

  Fly  4214 ELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIE---- 4274
            |.|:..|  .:|::         |..||.:.:.|.||||..|...| :..|:.:.|:..::    
  Rat   534 EGPEPWE--TISEE---------VNMAGDSLSLALPPPPASPVSRT-SPQELSEELSRRLQITPD 586

  Fly  4275 ---EQAS------PASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEV 4330
               ||.|      |:|...:...::..|::..||        .||.|.|:..|...:        
  Rat   587 SNGEQFSALIQREPSSRLRSCSVTDTVAEQAHLP--------PPSTPTRRARSSTVT-------- 635

  Fly  4331 LTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQ 4395
                 |..|...:||.:                 :.|..:....||.:.|      :.|.|.::.
  Rat   636 -----GGEESTPSVAYV-----------------HTTPGLPSGWEERKDA------KGRTYYVNH 672

  Fly  4396 GGAGTT-----SQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDR-FTAEHVIISAPKNA 4454
            ....||     .|.|....:.:||.|           .|..|...|.:.| .::..|.:|||...
  Rat   673 NNRTTTWTRPIMQLAEDGASGSATNS-----------NNHLVEPQIRRPRSLSSPTVTLSAPLEG 726

  Fly  4455 KPTCELQLPSMKKLMSN-SSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDI 4518
            .....:: .::|..:|| .|.||....:.|                                   
  Rat   727 AKDSPIR-RAVKDTLSNPQSPQPSPYNSPK----------------------------------- 755

  Fly  4519 EGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKST 4583
                           |....|.|..||....:||.:|          |.|         ....:|
  Rat   756 ---------------PQHKVTQSFLPPGWEMRIAPNG----------RPF---------FIDHNT 786

  Fly  4584 KPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNA 4648
            |.|         .|          |:.:.:|.|                    ..:|..|..|| 
  Rat   787 KTT---------TW----------EDPRLKFPV--------------------HMRSKASLNPN- 811

  Fly  4649 AGFGLRAAAGAGAIGGLGAAAPSAQEY-----SPFMDDVSSA------NTPSSASFDD------- 4695
                           .||...|..:|.     ..|..|.||.      :|..|....|       
  Rat   812 ---------------DLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESVPLYDSKITQWE 861

  Fly  4696 EPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFA 4760
            :||:|:     |.:|.|:                                               
  Rat   862 DPRLQN-----PAITGPA----------------------------------------------- 874

  Fly  4761 VLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSF-RVLYRLGPEEWKNRFY 4824
              |.::|  :|..|..||:.:|::..:...|.|  :.:.|..:||:|: |::....|:..|.|.:
  Rat   875 --VPYSR--EFKQKYDYFRKKLKKPADIPNRFE--MKLHRNNIFEESYRRIMSVKRPDVLKARLW 933

  Fly  4825 IVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSH-ANPNHLSYFKFVG 4888
            |.||.|:|.|.||:.|||:.::|:|:|||.|.||..|..|..|..|||:|. .|.:|||||.|:|
  Rat   934 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIG 998

  Fly  4889 RVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFST 4953
            ||...||...|||:.:|.|.|||.:||||:...||||.|.|:|..|.::::||.:.|  :|.|..
  Rat   999 RVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCI 1061

  Fly  4954 EVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISI 5018
            :.:.||.|...||||||.:..||.|||.||:.||.|.:....:::|::||||||.:::|..||.|
  Rat  1062 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 1126

  Fly  5019 FNEQELELLISGLPDIDIEDLKANTEY-HKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSK 5082
            |:|.|||||:.||.|:|:.|.:.::.| :.|......|||||:|:...|...|.:.||||||||:
  Rat  1127 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSR 1191

  Fly  5083 VPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEG 5147
            ||:.||..|.|.||.|.|.|.:.. |.::||.||||||:||||.|::::.||..||.|: |.::|
  Rat  1192 VPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQG 1254

  Fly  5148 F 5148
            |
  Rat  1255 F 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075 18/75 (24%)
HECTc 4796..5149 CDD:238033 164/356 (46%)
HECTc 4820..5148 CDD:214523 156/329 (47%)
Nedd4lXP_038952600.1 C2 <365..418 CDD:417471 13/78 (17%)
WW 463..489 CDD:395320 3/25 (12%)
WW 653..682 CDD:395320 7/34 (21%)
WW 766..796 CDD:238122 12/67 (18%)
WW 815..865 CDD:197736 10/49 (20%)
HECTc 926..1255 CDD:214523 156/332 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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