DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and Hecw1

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_017455974.1 Gene:Hecw1 / 291209 RGDID:1561038 Length:1603 Species:Rattus norvegicus


Alignment Length:1712 Identity:381/1712 - (22%)
Similarity:597/1712 - (34%) Gaps:567/1712 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  3553 DTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSP-NPQAPSA 3616
            :.|..:||:|:     .:|.....||:  .|......:|.|::..||..:::|.... .|:|||.
  Rat   342 EITSSIHADDE-----EISLNAEPESA--EVQDSVMNSVVENSSGEPPGDAAEFLKDLKPEAPSE 399

  Fly  3617 EPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDM----SPEVRAALGDLEVPEGVDP 3677
            |          |...|::. ...|.|.....|:|...|..|.    .||   .:|:|:.||..|.
  Rat   400 E----------DGVRGSEN-ENREHARPVEEAAGAMETRDDSKFSEGPE---EVGELQDPEQHDT 450

  Fly  3678 SFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPL--NIQSEVLMQQ 3740
            .     |:...|||.:.                                 |||  .....:|.::
  Rat   451 Q-----PTLSAEEVAER---------------------------------LPLGEGCPPSLLPEE 477

  Fly  3741 RIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQIASL---PPELAAEAQFLRRDW 3802
            ......:|.:.|.||:...        .|.:::....:.||..:::|   .|.|           
  Rat   478 STALGSKAEEEAIPENGAG--------EEEMQEKGKDEEEEEGVSALEQGEPGL----------- 523

  Fly  3803 ESRNGARMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQ-PQHHQ---HTTIVHQHPHA 3863
            |.|...|..:.|.|..:|..:|.:.|             |.|.|: |:.|.   | |::|..|.|
  Rat   524 ELRASVRKKSRPCSLPVSELETVIAS-------------ACGEAETPRTHYIRIH-TLLHSMPSA 574

  Fly  3864 HHAPNMGKPLALLMMEDENIL---LDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDW 3925
            .......:..|   ||:|:.|   .:.|.|:           :|::                   
  Rat   575 QRGSTTEEEDA---MEEESTLKESSEKDGLS-----------EVDT------------------- 606

  Fly  3926 IISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQA 3990
                 |:...::.||..|.||.......       |.:.|:.||:          ::||      
  Rat   607 -----IAADPQSMEDGENNGATLCMASS-------DCSGGHFSNL----------SKSI------ 643

  Fly  3991 AQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTG 4055
                                                               |||....|......
  Rat   644 ---------------------------------------------------GAGQDGEAHPSTGS 657

  Fly  4056 YDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAG 4120
            ..|..|....|.....|             |.....||     ..|||..:::..:::...|:..
  Rat   658 ESDSSPQQGADHSCEGC-------------DASCCSPS-----CYSTSCYSSSCYSSSCYSSSCY 704

  Fly  4121 SQNKHSVPYQTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQL 4185
            :.|.                         |.|:..:|            ::.|....|||     
  Rat   705 NGNN-------------------------RFASHTRF------------SSVDSAKISES----- 727

  Fly  4186 LEMLPYKVICRSPHLTDMLVKLLASLSTELPKEE-----ELLPLSDQMPPLVP-----IGPVQRA 4240
                                   ...|::..:||     |.:|.|.|.|.|.|     .||.|..
  Rat   728 -----------------------TVFSSQEDEEEENSAFESVPDSVQSPELDPESTNGAGPWQDE 769

  Fly  4241 GAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVAL 4305
            .||           |..|.|..||   ||            .:|.:|.||  .:....|.|..:.
  Rat   770 LAA-----------PGGNAARTTE---GL------------DSPMAGPSN--RREGDCPMLHNSQ 806

  Fly  4306 PVT--PS-KPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLT 4367
            |::  || :|....|......|....|......|....:|:     ||.|...|..|      :.
  Rat   807 PISQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDH-----VNRTTTWQRPS------MA 860

  Fly  4368 AAILGL--AEEVRQAIQMLLNEIRMYNIHQ------------------------GGAGTTSQAAS 4406
            ....|:  :..|.|..|  ||. |..||.:                        ||.|:.|:|.|
  Rat   861 PTPDGMIRSGSVHQMEQ--LNR-RYQNIQRTIATERSEEDSGNQSCEQIPDGGAGGGGSDSEAES 922

  Fly  4407 TSGAAAATASYVPTVSGASLLPNLAV-HEGIMQDRFTAEHVIISAPKNA-KPTCELQLPSMK--- 4466
            :..                   ||.: .||.:            :|.|: |.|..||.|::|   
  Rat   923 SQS-------------------NLDLRREGSL------------SPVNSQKVTLLLQSPAVKFIT 956

  Fly  4467 ------KLMSNSSAQPYFLRT-------LKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDII-- 4516
                  .|.:|.||...|..:       ||:....|:....|               ::.|::  
  Rat   957 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQ---------------HNRDLVNF 1006

  Fly  4517 ---------------DIEGDGGASGGSSSDMAPGSAST--ISPPPPMETNQIAQD---------- 4554
                           :|:.|   ..|.|..:...|.:|  |.|..|::..::...          
  Rat  1007 INMFADTRLELPRGWEIKTD---HQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRL 1068

  Fly  4555 -----GDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEF 4614
                 |:..|...:...|......|::.:|.:|.    .|...|.:.:|             |:.
  Rat  1069 RSYSAGEASEVSRNRGASLLARPGHSLIAAIRSQ----HQHESLPLAYN-------------DKI 1116

  Fly  4615 AVLVLQPTVEAFFLIHASH----RGASKKSGRSFMPNAAGFGL-RAAAGAGAIGGLGAAAPSAQE 4674
            ...:.||.:  |.::....    |..:.:....::......|| :.:..|..:..|.........
  Rat  1117 VAFLRQPNI--FEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMS 1179

  Fly  4675 YSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKH 4739
            |.|    :.||..|   .:...||....|       :|..|..:....|:               
  Rat  1180 YVP----LQSAFHP---GYSFSPRCSPCS-------SPQNSPGLQRASAR--------------- 1215

  Fly  4740 RTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVF 4804
                           :..|:.        .||:.|.:.|..:||....|....:..:.:||..:.
  Rat  1216 ---------------APSPYR--------RDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL 1257

  Fly  4805 EDSF-RVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTY 4868
            |.:| :|:.....|..:|:.||.|..|||.|..|..||::.::|:|:|||.|.||..|..|..|.
  Rat  1258 EGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTV 1322

  Fly  4869 MINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKG 4933
            .|:|.|....|:|.:|:|.||::..|:....||:.:|||.|||.:|......:|:|..|.||::.
  Rat  1323 QISPMSAFVENYLEWFRFSGRILGLALIHQYLLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQS 1387

  Fly  4934 LDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQ 4998
            |.::..|:|:.: .:|||:...:.||....|:||..|.:|.|||:||.||::.:.:.::...:.|
  Rat  1388 LQWMKDNNITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQ 1451

  Fly  4999 QLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRAL 5062
            |.:|.:.|||:::...|:|:|:.:||||:|:|..:||:.|.:.||||. .|......|:|||.|:
  Rat  1452 QTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAV 1516

  Fly  5063 RSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMY 5127
            ..|:...|.:.||||||||.||.:||.:|.|.||:::|.|.:..:.|. ||.||||||:||||.|
  Rat  1517 ERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPY 1580

  Fly  5128 KSYDKLRSCLLKAIHECSEGFG 5149
            .||..|...||.|:.|.|. ||
  Rat  1581 PSYSTLYEKLLTAVEETST-FG 1601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 18/76 (24%)
DUF4414 3675..3779 CDD:291075 14/105 (13%)
HECTc 4796..5149 CDD:238033 142/354 (40%)
HECTc 4820..5148 CDD:214523 136/328 (41%)
Hecw1XP_017455974.1 HECW_N 66..185 CDD:293170
C2_NEDL1-like 206..342 CDD:176073 381/1712 (22%)
WW 827..857 CDD:197736 8/34 (24%)
WW 1017..1048 CDD:197736 8/33 (24%)
HECTc 1247..1601 CDD:238033 142/356 (40%)
HECTc 1271..1600 CDD:214523 137/331 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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