DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and WWTR1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001161750.1	Gene:	WWTR1 / 25937	HGNCID:	24042	Length:	400	Species:	Homo sapiens

Alignment Length:	324	Identity:	65/324 - (20%)
Similarity:	107/324 - (33%)	Gaps:	117/324 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  3545 PPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPT-------PE 3602
            |||.|||..  .::|...||                   .|:.....|....|:|:       ||
Human     7 PPPLPPPGQ--QVIHVTQDL-------------------DTDLEALFNSVMNPKPSSWRKKILPE 50

  Fly  3603 S--------SESTSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTA------ 3653
            |        |.|...:..:....|.|...|.|  ..|.:.:...:.:..:.|||:|:.|
Human    51 SFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGA--QHVRSHSSPASLQLGTGAGAAGSPAQQHAHL 113

  Fly  3654 -----TITDMSPEVRAALGDLEVPEGVDPSFLA-------------ALPSEMREEVIQ--EHLRM 3698
                 .:||          :|.:|.|.:.:|.|             ....:.|:.:.|  .|:.:
Human   114 RQQSYDVTD----------ELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNL 168

  Fly  3699 ----------QRIRQRAQQNAI-------QIAHDSLVEVN------PEFLAALPLNI-----QSE 3735
                      ||....:|.|.:       |:|..:|.:.|      |..|.::|..:     |.:
Human   169 HPAVSSTPVPQRSMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQ 233

  Fly  3736 VLMQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQIASL-----PPELAAE 3794
            .|..|||:.:|:..:....|.....||..:.||          ||...:|.:     ||.:..:
Human   234 KLRLQRIQMERERIRMRQEELMRQEAALCRQLP----------MEAETLAPVQAAVNPPTMTPD 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	17/90 (19%)
		DUF4414	3675..3779	CDD:291075	27/146 (18%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
WWTR1	NP_001161750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..117		12/66 (18%)
		WW	125..156	CDD:197736	4/30 (13%)
		Required for interaction with PALS1. /evidence=ECO:0000269\|PubMed:21145499	222..400		17/76 (22%)
		PDZ-binding	394..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900