Protein Alignment HUWE1 and pub3

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_595793.1
• Gene: pub3 / 2539956
• PomBaseID: SPBC16E9.11C
• Length: 786
• Species: Schizosaccharomyces pombe
• Alignment Length: 680
• Identity: 222/680 - (32%)
• Similarity: 331/680 - (48%)
• Gaps: 88/680 - (12%)

  Fly  4525 SGGSSSDMAPGSAST----------ISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASA 4579
            :|..||..|..:.||          .:|.|...||...|...:...:...|.:..|.|..|...|
pombe   138 AGNHSSTTANRTTSTPTTTTARTTRTTPRPTATTNTSNQSTSNSTRNGTSAATSNGTGTGAGTGA 202

  Fly  4580 SKSTKP-TLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRS 4643
            |..:.| |..|......|.|:.:..:.:.|:....     |.|..|.          .:...||:
pombe   203 SHRSSPVTNRQTNNTSALSNSNAHIMSSFEDQYGR-----LPPGWER----------RADSLGRT 252

  Fly  4644 FMPN---AAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEP---RMQDA 4702
            :..:   ......|.|:....:....:.:......:..:.|.|:.:...|.|.:|.|   .|:..
pombe   253 YYVDHNTRTTTWTRPASSTNPVHNTSSDSQRLNHQNRHLPDDSNPSLMQSDSGNDLPFGWEMRYT 317

  Fly  4703 STNTPLVT--NPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPF------ 4759
            .|..|...  |..|:|.:......:|.:...        .||.:.:..||.:||  ||.
pombe   318 DTGRPYFVDHNTRTTTWVDPRNPLVRPNGGS--------STVGSLMQPQSLSHL--GPLPSGWEM 372

  Fly  4760 -------AVLVDHT------------RILDFDV-------KRK--YFQTELERLDEGIR--REEH 4794
                   ...|||.            ..||.||       :||  ||:::     .|:|  ..:.
pombe   373 RLTNSARVYFVDHNTKTTTWDDPRLPSALDQDVPQYKCDFRRKLIYFRSQ-----PGMRPLPGQC 432

  Fly  4795 TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFC 4859
            .|.|||..:||||:..:.|....:.|.|..|.|:.|:|.|.|||.||::.::|.::|:|:|.||.
pombe   433 NVKVRRDHIFEDSYAEIMRYSAHDLKKRLMIRFDGEDGLDYGGLSREFFFLLSHKMFDPIYCLFE 497

  Fly  4860 VSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDME 4924
            .|..|..|..|||.|..||.||:||:|:||||..|:...:.|:.:|..|.||.:|.|:|...|||
pombe   498 YSAVDNYTLQINPHSSINPEHLNYFRFIGRVIGLAIFHRRFLDAFFVVSLYKKLLRKKVSLADME 562

  Fly  4925 SQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQ 4989
            |.|.|||:.|.::::|||:.: .:||||.|...||..:..:|..||.:..||||||.:||.||.:
pombe   563 SIDAEFYRSLKWVLENDITGI-LDLTFSVEEDHFGEVRTVELITNGENIEVTEENKKKYVDLVTE 626

  Fly  4990 LKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQ 5054
            .::|..:.||.:||..||.:::...|:::|:|:||||||.|:.|:|:||.|::|||..|.:....
pombe   627 WRVSKRVEQQFNAFYSGFVELVSPDLVNVFDERELELLIGGISDVDVEDWKSHTEYRTYIATDPV 691

  Fly  5055 IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCF 5119
            |:|||..:..:...||:|.|||.||||::|:.||..|:|.:|.:||.|.:.. :.|:||.|||||
pombe   692 IKWFWEIIAGWKNEDRSKLLQFATGTSRIPVNGFRDLQGSDGPRKFTIEKAG-TPDQLPVAHTCF 755

  Fly  5120 NQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            |:||||.|.|.|.|...|..|: |.:.|||
pombe   756 NRLDLPDYPSKDTLHEKLSLAV-ENTVGFG 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	156/352 (44%)
pub3	NP_595793.1	HUL4	4..786	CDD:227354	222/680 (33%)