DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Plekha5

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_647556.1	Gene:	Plekha5 / 246237	RGDID:	621175	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	1091	Identity:	198/1091 - (18%)
Similarity:	314/1091 - (28%)	Gaps:	432/1091 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  3017 NFIRISGGDSSMGSGPAIGG--------NANGGDMNVFITPSMSLERAGGAPGSG---------- 3063
            |.::::...|...||||...        |.|..|... :..|::..|.|..|.:|
  Rat   349 NSVKLNSLPSEYESGPACPPQNIHYRPINVNNSDSKA-VNVSLADVRGGSHPNTGPLATEADRVI 412

  Fly  3064 ---QTMSEL-----------LNEQPTGAGGGGGGGSASGVGGVGAN-----GGTTGQHPNA--TL 3107
               .:|.:|           |.|:|.|         ......:..|     .....::|..  ||
  Rat   413 QRTNSMQQLEQWIKVQKGRGLEEEPRG---------VISYQTLPRNMPSHRAQILARYPEGYRTL 468

  Fly  3108 CTNGVRRRLLYLDQQYCVCMPT-HQ--NPTEETQMETFTQDALHWWLEEATLLDMESQTDACLYA 3169
            ..|...|     .:..|...|: |:  .|..|.:..:...|.: |.|.|
  Rat   469 PRNSKTR-----PESICSVTPSGHEKTGPGAEEKRRSMRDDTM-WQLYE---------------- 511

  Fly  3170 AHFLLPHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLA 3234
                           .|||:...  :|||.|..      :..|:...:|..:.....||
  Rat   512 ---------------WQQRQFYH--KQSTLPRH------SCLSSPKAMGKVSDQTMHSI------ 547

  Fly  3235 NAVSAGSGSSSLVVPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGP 3299
                                                   |:|.|...:|...|.:         |
  Rat   548 ---------------------------------------PTSPSHVPAAAYQGFS---------P 564

  Fly  3300 TRNFSSVDSNVSSETQTTTRPPRQRGGL----RQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTG 3360
            .|.:.   |.|||        |.|||.:    |.:...|.::|..           || .|...|
  Rat   565 QRTYR---SEVSS--------PIQRGDVTIDRRHRPHHPKHVYVP-----------DR-RSMPAG 606

  Fly  3361 TAADGAESQSQHNSS-----------------------STAAQVAVPQHQRHPP----------- 3391
            .|......||.|..:                       .|.||:...:.:.|.|
  Rat   607 LALQAVSPQSLHGRTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQR 671

  Fly  3392 -VPLLPSSGRPSRP-----HTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPN 3450
             ...|....:.:.|     ||.: |...|..||..:.:|.:.:.|....:.....|: |...||.
  Rat   672 NTIYLDHQMKENEPIITMVHTMI-ENSALRPQLYQQFLRQKNKISLYCLSQDECRGT-LYKYRPE 734

  Fly  3451 R-DLPACLQR------------------HDH---------PAGSIFPRPSANRTPAPTLVSMPTP 3487
            . |:.|.|.|                  |..         .|.......:.|.....|:|.....
  Rat   735 EVDIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDD 799

  Fly  3488 MSNAAL---EQLNVTAPDVVRTDRNFALPSSLEVDV----------------------------- 3520
            :.|..|   .:|:....::.|..|.:   ..||.||
  Rat   800 LQNGLLSTCRELSRATAELERAWREY---DKLEYDVTVTRNQMQDQLDRLGEVQSESAGIQRAQI 861

  Fly  3521 --------DVLPGIVDLPQQEA-----------------QPEDDQLLLPPPP------------- 3547
                    ||:.|:....||..                 :.|:::::.|.||
  Rat   862 QKELWRIQDVMEGLSKHKQQRGSSETGLAGPKPFPAVKYKSEEEEVVPPRPPLPRSYDFTEQPPI 926

  Fly  3548 -PPPPSDTTPL-------VHAEDDL-------WP--GTVVSAGTREESSAPAVATESTEAVNESN 3595
             ||.|||::.|       ||..::.       :|  |:......|...|.|.:.|  ...|:|||
  Rat   927 IPPLPSDSSSLLCYSRGPVHLPEEKKSHQVQGYPRNGSHCGPDYRLYKSEPELTT--VAEVDESN 989

  Fly  3596 QPEPTPESSESTSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSP 3660
            ..|.:..:||:.:           |:..|:.....|..:|.:.|.|:::.  ||..|...|....
  Rat   990 GEEKSEPASEAEA-----------PVVRGSHFPVGVPLRTKSPTPESSTI--ASYVTLRKTKKMV 1041

  Fly  3661 EV-----RAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQI--AHDSLV 3718
            |:     |:|:..|.:.|...|....       ||.::...|.|:...|.::..:.:  |.|...
  Rat  1042 ELRTERPRSAVEQLCLAESTRPRMTV-------EEQLERIRRHQQACLREKKKGLNVLSASDPSP 1099

  Fly  3719 EVNPEFLAALPLNIQSEVLMQQRIEQ--------------QRQAAQTANPEDPVDTAA------- 3762
            ..:|..:...|..:...|......::              ...||:||:||:....:|
  Rat  1100 SQSPSSVRDSPSRVPQTVRRDDNTKELDAVHRENDGKPDYDTSAAETAHPEEAEPQSADVGRKLK 1164

  Fly  3763 -----FFQNL--PENL-----RQAILTDMEESQI------------------ASLPPELAAEAQF 3797
                 |::.|  ||.|     .:.:..:.:|.|:                  |..|||   ||:.
  Rat  1165 RTESIFYEMLYTPEPLNGLTSEEVMAKERQEEQVPEGAVCSLQEEAAMANHQAEGPPE---EAES 1226

  Fly  3798 LRRDWESRNGARMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQP 3848
            |..:.|    |.....|........|||::||..:.       |:|..|.|
  Rat  1227 LHEEEE----ALASCEPAPETPRENQTTVKSLSPSP-------DSSTAADP 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	19/75 (25%)
		DUF4414	3675..3779	CDD:291075	23/138 (17%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
Plekha5	NP_647556.1	WW	13..42	CDD:278809
		WW	59..88	CDD:278809
		PH_PEPP1_2_3	165..268	CDD:270068
		PH	171..267	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900