DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and WWC1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_011532787.1	Gene:	WWC1 / 23286	HGNCID:	29435	Length:	1185	Species:	Homo sapiens

Alignment Length:	960	Identity:	180/960 - (18%)
Similarity:	305/960 - (31%)	Gaps:	343/960 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  3097 GTTGQHPNATLCTNGVRRRLLYLDQQ---YCVC---MPTHQNPTEETQMETFTQDALHWWLEEAT 3155
            |:.|.:.|..|... ||.||.|.:.:   .|.|   .|::...|.....:..::.|.|.:|:...
Human   288 GSFGINSNNQLAEK-VRLRLRYEEAKRRLSCQCGQATPSNSELTHYQLPQASSKTARHLYLDSHF 351

  Fly  3156 LLDMESQT----------DACL-YAAH-------------------------------------- 3171
            |..::..|          :||| :.|:
Human   352 LFSLKRTTLNLGSVPSCRNACLRWIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMR 416

  Fly  3172 FLLP----------------HLIKELKAAHQQ-------------------RKQEEAARQSTTPA 3201
            |:.|                .|.|:|:||...                   |:.|||.||..|
Human   417 FISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVAT-- 479

  Fly  3202 SGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSS--SLVVPP-------------- 3250
            ..|...:.|||..|:...::|.:.:|....|:|:::.:.:.:|  .|...|
Human   480 LHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEF 544

  Fly  3251 -VAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPTRNFSSVD--SNVSS 3312
             :...|||......|     :|:.....:....|.|.|......:.:|.| ::.:|:.  |::||
Human   545 LLLEGATGFRPSGCI-----TTIHEDEVAKTQKAEGGGRLQALRSLSGTP-KSMTSLSPRSSLSS 603

  Fly  3313 ETQTTTRPPRQ-------RGGLRQQSQLPFN------IYAEIDLTN---------EQDSEG---- 3351
            .:     ||..       ..|....:.|.|.      ...|:.|.|         |..:||
Human   604 PS-----PPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLG 663

  Fly  3352 ---------------------DRSTSTTTGT---------AADGAESQSQHNSS--STAAQVAVP 3384
                                 |.|.:..:|.         |::.|...|..:.:  :|..|:|:.
Human   664 QAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALK 728

  Fly  3385 QHQRHPPVPLLPSSGRPSRPHTRLDETEL-LLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINAR 3448
            ..:::....:|           .:..:.| .|||..|:::..|                  :...
Human   729 YDEKNKQFAIL-----------IIQLSNLSALLQQQDQKVNIR------------------VAVL 764

  Fly  3449 PNRDLPACLQRHDHPAGSIFPRPSANRTPAPTLVSMP---TPMSNAALEQLNVTAPDVVRTDRNF 3510
            |..:...||.|         .||   ...:.|||...   ..||..||.|..:.. ||..|||
Human   765 PCSESTTCLFR---------TRP---LDASDTLVFNEVFWVSMSYPALHQKTLRV-DVCTTDR-- 814

  Fly  3511 ALPSSLEVDVDVLPGI-----------------VDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLV 3558
               |.||   :.|.|.                 .:|...:...:..:.|.|.....|.|.....|
Human   815 ---SHLE---ECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKPVGVMAPASGPASTV 873

  Fly  3559 HAEDD----LWPGTVVSAGTREE-----------------SSAPAVATESTEAVNESNQPEPTPE 3602
            ..:.|    |...|.|....|:|                 |...|||.|..|.|.|....|..
Human   874 SWDQDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDV-- 936

  Fly  3603 SSESTSP--------------NPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTA 3653
            .:|..||              |.:.|:..||.:.|   .|..||     |..:.....|::...:
Human   937 FTEKASPDMDGYPALKVDKETNTETPAPSPTVVRP---KDRRVG-----TPSQGPFLRGSTIIRS 993

  Fly  3654 TITDMSPE----VRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQ-IA 3713
            ......|:    .|....|      .|.|.|:..|..:|..:.:..:||:|.....|.:::: :.
Human   994 KTFSPGPQSQYVCRLNRSD------SDSSTLSKKPPFVRNSLERRSVRMKRPSPPPQPSSVKSLR 1052

  Fly  3714 HDSLVEVNPEFLAALPLNIQS----------EVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNLP 3768
            .:.|:..:.:    |.|::|:          |:.:.:.:::|.:.|::...::          ||
Human  1053 SERLIRTSLD----LELDLQATRTWHSQLTQEISVLKELKEQLEQAKSHGEKE----------LP 1103

  Fly  3769 ENLRQ-----AILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMDAH 3813
            :.||:     .:|..:|:.|:     :.|.....|:.|...|..|: |.|
Human  1104 QWLREDERFRLLLRMLEKRQM-----DRAEHKGELQTDKMMRAAAK-DVH 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	24/106 (23%)
		DUF4414	3675..3779	CDD:291075	21/119 (18%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
WWC1	XP_011532787.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	429..>481	CDD:299846	12/53 (23%)
		C2_Kibra	721..844	CDD:176062	34/172 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900