DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and HECW1

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_016867371.1 Gene:HECW1 / 23072 HGNCID:22195 Length:1639 Species:Homo sapiens


Alignment Length:2230 Identity:444/2230 - (19%)
Similarity:707/2230 - (31%) Gaps:853/2230 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  3093 GANGGTTGQHPNAT----LCTNGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQD-ALHWWLE 3152
            |.:.|.|  .|.:|    |.|:..|..|:.....|.:               ..:|| .:||   
Human    88 GPHDGVT--IPRSTSDTDLVTSDSRSTLMVSSSYYSI---------------GHSQDLVIHW--- 132

  Fly  3153 EATLLDMESQTDACLYAAHFLLPHLIKE---------LKAAHQQR--KQEEAARQSTTP------ 3200
                 |::.:.||..:...:|:..::.|         :..:|:.:  .:.:|:.....|      
Human   133 -----DIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICF 192

  Fly  3201 -----ASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVPPVAASATGGTR 3260
                 .||:..:.|.|.|  |..:|||     |...:.|:....|.||..|:...::.....|.:
Human   193 KYYHGVSGALRATTPSVT--VKNSAAP-----IFKSIGADETVQGQGSRRLISFSLSDFQAMGLK 250

  Fly  3261 RSSI----PVL-ISSTLGPSSASSATSATGNGATSDATTTTGGP-----TRNFSSVDSNVSSETQ 3315
            :...    |.| ||...|..|...|....|....|.....|..|     ..:|.|:.::| .|.:
Human   251 KGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDV-LEIE 314

  Fly  3316 TTTRPPRQRGGLRQ---QSQLPFNIYAEIDLTNEQDSEGDRSTSTTTG--TAADGAESQSQHNSS 3375
            ...:..:.|..:::   :..:|      :....|:.:.|||..|.|.|  ...|....|.|....
Human   315 VKDKFAKSRPIIKRFLGKLSMP------VQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFE 373

  Fly  3376 STAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLL------LQLTDRQIRNRLQGSSGHT 3434
            .|::        .||                 .|:.|:.|      .|:.|..:.|.::..||..
Human   374 ITSS--------IHP-----------------ADDEEISLSTEPESAQIQDSPMNNLMESGSGEP 413

  Fly  3435 NSSRTSGS--------------------ALINARPNRDLPACLQRHDH------PAGS------- 3466
            .|.....|                    ::..:||..:.....:..|.      |.|:       
Human   414 RSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQV 478

  Fly  3467 ---IFPRPSA--------------------NRTPAPT----LVSMPTPMSNAALEQ--------- 3495
               |.|.|||                    ...||.|    |....|..|.|..|:         
Human   479 QKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEG 543

  Fly  3496 -----------LNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPP 3549
                       |.:.| .|.|..|..:||.| |::..:.....|                   |.
Human   544 DVSTLEQGEGRLQLRA-SVKRKSRPCSLPVS-ELETVIASACGD-------------------PE 587

  Fly  3550 PPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNPQA- 3613
            .|......:|......|.....:...||..|     |....:.:|::.:...| .::.:.:|.| 
Human   588 TPRTHYIRIHTLLHSMPSAQGGSAAEEEDGA-----EEESTLKDSSEKDGLSE-VDTVAADPSAL 646

  Fly  3614 --PSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVD 3676
              ...||....||.|.....|...|:....||.......:|.:.:|.||...   ||... ||.|
Human   647 EEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDSSPRQG---GDHSC-EGCD 707

  Fly  3677 -----PSFLAA------------------LPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLV 3718
                 ||..::                  .||.........|.|...:      ::.:|:     
Human   708 ASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSV------DSAKIS----- 761

  Fly  3719 EVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQ 3783
                          :|.|...|..|::..:|              |:::|::::.          
Human   762 --------------ESTVFSSQDDEEEENSA--------------FESVPDSMQS---------- 788

  Fly  3784 IASLPPELAAEAQFLRRDWESRNGA---RMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASG- 3844
                 |||         |.||.|||   :.:...||..:.|....|:|            ..:| 
Human   789 -----PEL---------DPESTNGAGPWQDELAAPSGHVERSPEGLES------------PVAGP 827

  Fly  3845 ------------NAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFL 3897
                        |:||.    :.:....|..||.|.:.:||             |.:.       
Human   828 SNRREGECPILHNSQPV----SQLPSLRPEHHHYPTIDEPL-------------PPNW------- 868

  Fly  3898 FVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDA 3962
               :.:::|   |..:..:.|...|..|         |:..          |...|:.::     
Human   869 ---EARIDS---HGRVFYVDHVNRTTTW---------QRPT----------AAATPDGMR----- 903

  Fly  3963 AFGYKSNIFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILS 4027
            ..|....:..:||.|:...|:|:..........::|                             
Human   904 RSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSC----------------------------- 939

  Fly  4028 AVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKP 4092
                 ....||.|||.||.|.|....:..|....|......|:    ::...|:|         |
Human   940 -----EQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQ----KITLLLQS---------P 986

  Fly  4093 SVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSV-PYQTNAKNFWDVVLNIDQQTQVRLANVAQ 4156
            :|.....|.......|..:| .:|.|:.:..||.: ..:.:|:||                    
Human   987 AVKFITNPEFFTVLHANYSA-YRVFTSSTCLKHMILKVRRDARNF-------------------- 1030

  Fly  4157 FPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEEL 4221
                     |...:..|.::|                           :.:.|....|||:..|:
Human  1031 ---------ERYQHNRDLVNF---------------------------INMFADTRLELPRGWEI 1059

  Fly  4222 LPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQASPASGNPAS 4286
              .:||.            |.:....|         |:...|.|                 :|  
Human  1060 --KTDQQ------------GKSFFVDH---------NSRATTFI-----------------DP-- 1082

  Fly  4287 GDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNL 4351
                      ::|..:..||                      ..|||                  
Human  1083 ----------RIPLQNGRLP----------------------NHLTH------------------ 1097

  Fly  4352 TQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATAS 4416
                                      ||.:|.|    |.|                   :|..||
Human  1098 --------------------------RQHLQRL----RSY-------------------SAGEAS 1113

  Fly  4417 YVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRT 4481
            .|....|||||..             ..|.:::|.::......|.|....|:::       |||.
Human  1114 EVSRNRGASLLAR-------------PGHSLVAAIRSQHQHESLPLAYNDKIVA-------FLRQ 1158

  Fly  4482 LKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPM 4546
            ..||..:::.                                                   .|.:
Human  1159 PNIFEMLQER---------------------------------------------------QPSL 1172

  Fly  4547 ETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESK 4611
            ..|...:         ::.......|||.           |.::.|                   
Human  1173 ARNHTLR---------EKIHYIRTEGNHG-----------LEKLSC------------------- 1198

  Fly  4612 DEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYS 4676
            |...|::|....|...               |::|      |:||...|              ||
Human  1199 DADLVILLSLFEEEIM---------------SYVP------LQAAFHPG--------------YS 1228

  Fly  4677 PFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRT 4741
             |....|..::|.::     |.:|.||...|                                  
Human  1229 -FSPRCSPCSSPQNS-----PGLQRASARAP---------------------------------- 1253

  Fly  4742 VLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFED 4806
                    ||             :.|  ||:.|.:.|..:||....|....:..:.:||..:.|.
Human  1254 --------SP-------------YRR--DFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEG 1295

  Fly  4807 SF-RVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMI 4870
            :| :|:.....|..:|:.|:.|..|||.|..|..||::.::|:|:|||.|.||..|..|..|..|
Human  1296 TFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQI 1360

  Fly  4871 NPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLD 4935
            :|.|....|||.:|:|.||::..|:....||:.:|||.|||.:|......:|:|..|.||::.|.
Human  1361 SPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQ 1425

  Fly  4936 YLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQL 5000
            ::..|:|:.: .:|||:...:.||....|:||..|.:|.|||:||.||::.:.:.::...:.||.
Human  1426 WMKDNNITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQT 1489

  Fly  5001 DAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRS 5064
            :|.:.|||:::...|:|:|:.:||||:|:|..:||:.|.:.||||. .|......|:|||.|:..
Human  1490 EALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVER 1554

  Fly  5065 FDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKS 5129
            |:...|.:.||||||||.||.:||.:|.|.||:::|.|.:..:.|. ||.||||||:||||.|.|
Human  1555 FNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPYPS 1618

  Fly  5130 YDKLRSCLLKAIHECSEGFG 5149
            |..|...||.|:.|.|. ||
Human  1619 YSMLYEKLLTAVEETST-FG 1637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 17/78 (22%)
DUF4414 3675..3779 CDD:291075 15/126 (12%)
HECTc 4796..5149 CDD:238033 142/354 (40%)
HECTc 4820..5148 CDD:214523 136/328 (41%)
HECW1XP_016867371.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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