DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and Yap1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_006509915.1	Gene:	Yap1 / 22601	MGIID:	103262	Length:	494	Species:	Mus musculus

Alignment Length:	468	Identity:	102/468 - (21%)
Similarity:	163/468 - (34%)	Gaps:	126/468 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  3188 RKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVP-PV 3251
            ||..::..:...|.|.|..::|.:.|...:......|.||.|| |...|||.|:.::|.||. |.
Mouse    74 RKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPAS-LQLGAVSPGTLTASGVVSGPA 137

  Fly  3252 AASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPTRNFSSVDSNVSSETQT 3316
            ||.|....|:||..:.....| |:....|.:::|.              |.|      ::...||
Mouse   138 AAPAAQHLRQSSFEIPDDVPL-PAGWEMAKTSSGQ--------------RYF------LNHNDQT 181

  Fly  3317 TT-RPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADGAESQSQHNSSSTA-- 3378
            || :.||:  .:..|..:|......:..|....:.|............||......|.:.:|:
Mouse   182 TTWQDPRK--AMLSQLNVPAPASPAVPQTLMNSASGPLPDGWEQAMTQDGEVYYINHKNKTTSWL 244

  Fly  3379 -----AQVAVPQHQR--------HPPVPLLPSS-------GRPSRPHTRLD------ETELLLLQ 3417
                 .:.....:||        .|| ||.|.|       |..|....::.      |.|.|.|:
Mouse   245 DPRLDPRFGKAMNQRITQSAPVKQPP-PLAPQSPQGGVLGGGSSNQQQQIQLQQLQMEKERLRLK 308

  Fly  3418 LTD--RQIRNRLQGSSGHTNSSRTSGSALINARPN-RDLPAC--------LQRHDHPAGSIFPRP 3471
            ..:  ||:|.:                |:.|..|: .:.|.|        |...:...|:    |
Mouse   309 QQELFRQVRPQ----------------AIRNINPSTANAPKCQELALRSQLPTLEQDGGT----P 353

  Fly  3472 SANRTP--APTLVSMPTPMSNAALEQ-------------LNVTAPDVVRTDRNFALPSSLEVDVD 3521
            :|..:|  :..|.:|.|..|:..|..             |::::..:.||..:| |.|..|:|..
Mouse   354 NAVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSIPRTPDDF-LNSVDEMDTG 417

  Fly  3522 VLPGIVDLPQQEAQ-PEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVAT 3585
            .......||.|::: |:..:.|                       |||.|..||.|..:......
Mouse   418 DTISQSTLPSQQSRFPDYLEAL-----------------------PGTNVDLGTLEGDAMNIEGE 459

  Fly  3586 ESTEAVNESNQPE 3598
            |...::.|:...|
Mouse   460 ELMPSLQEALSSE 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	4/24 (17%)
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
Yap1	XP_006509915.1	FAM181	<61..>141	CDD:373671	23/67 (34%)
		WW	159..188	CDD:238122	9/48 (19%)
		WW	217..246	CDD:366073	4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900