Protein Alignment HUWE1 and Ube3a

DIOPT Version :9

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001380595.1
• Gene: Ube3a / 22215
• MGIID: 105098
• Length: 870
• Species: Mus musculus
• Alignment Length: 950
• Identity: 230/950 - (24%)
• Similarity: 371/950 - (39%)
• Gaps: 238/950 - (25%)

  Fly  4327 VIEVLTHQCGTTEGLDNVAKLIVNLTQCSQ---ASSAIFIQYLTAAILGLAEEVRQAIQMLLNEI 4388
            :||...||  .|||..|.|        |:.   ||...|::         .:....||:.|
Mouse    30 LIERYYHQ--LTEGCGNEA--------CTNEFCASCPTFLR---------MDNNAAAIKAL---- 71

  Fly  4389 RMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQD-----RFTAEHV-- 4446
            .:|.|:   |.......|..||::|   |:....|||....:.:::...:|     ..|.|.|
Mouse    72 ELYKIN---AKLCDPHPSKKGASSA---YLENSKGASNNSEIKMNKKEGKDFKDVIYLTEEKVYE 130

  Fly  4447 -------------IISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGL 4498
                         :|........:.|..:.|.:|:..::..:   |::|:...:.:|..|.:.
Mouse   131 IYEFCRESEDYSPLIRVIGRIFSSAEALVLSFRKVKQHTKEE---LKSLQEKDEDKDEDEKEK-- 190

  Fly  4499 STGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDD 4563
                 .||.|...::|          |..|||.|...|..         .|.:.:.|.||...|.
Mouse   191 -----AACSAAAMEED----------SEASSSRMGDSSQG---------DNNVQKLGPDDVTVDI 231

  Fly  4564 EA--RSFPG-VGNHAVASASKSTKPTLSQILCLDVLW--------NTLSECLVALEES---KDEF 4614
            :|  |.:.. :.|..:.:|..:....||..:..|:.:        |.|:..::.:|.|   ..|:
Mouse   232 DAIRRVYSSLLANEKLETAFLNALVYLSPNVECDLTYHNVYTRDPNYLNLFIIVMENSNLHSPEY 296

  Fly  4615 AVLVLQPTVEAFFLIHASHRGA-----SKKSG---RSFMPN------------------------ 4647
            ..:.|....:|...:....:|.     ||.|.   |..|..
Mouse   297 LEMALPLFCKAMCKLPLEAQGKLIRLWSKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDD 361

  Fly  4648 ---AAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANT--------PSSAS------FDD 4695
               ||...|:....|..:||                ||.:.:.        |.|:.      ..|
Mouse   362 AIVAASKCLKMVYYANVVGG----------------DVDTNHNEEDDEEPIPESSELTLQELLGD 410

  Fly  4696 EPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHL-----S 4755
            |.|.:......||.|.....|.         ..|:..:.|.|.....||.:|.....:.     :
Mouse   411 ERRNKKGPRVDPLETELGVKTL---------DCRKPLISFEEFINEPLNDVLEMDKDYTFFKVET 466

  Fly  4756 DGPFAVL--------VDHTRILDFDVK-RKYFQ---TELERLDEGIRREEH-TVSVRRVTVFEDS 4807
            :..|:.:        |.....|.:|.: |.|.:   |.|..|.:|.:...: .:.|||..:.:|:
Mouse   467 ENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDA 531

  Fly  4808 FRVLYRL------GPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRV 4866
               |.||      .|.:.|.:.|:.||.|:|.|.||:.:|::.::..|||||...:|......::
Mouse   532 ---LVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATKL 593

  Fly  4867 TYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFY 4931
             :..||||......   |..:|.|:..|:::|.:|:.:|....|:.::||:....|:.......|
Mouse   594 -FWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLY 654

  Fly  4932 KGLDYLMKNDISTLGYE--------LTFS-TEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLV 4987
            :.|..|::       ||        :||. ::...||...:.|||.||....:|.||:.|:|.|.
Mouse   655 QSLKDLLE-------YEGSVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLY 712

  Fly  4988 CQLKMSGSIRQQLDAFLEGFYDIIPKHLIS-------IFNEQELELLISGLPDIDIEDLKANTEY 5045
            ....::.|:.:|..||..||      |:::       :|..:|:||||.|..::|.:.|:..|||
Mouse   713 SDYILNKSVEKQFKAFRRGF------HMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY 771

  Fly  5046 H-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRST 5109
            . .||.:|..|:.||..:.||....:..||||.|||.:.|:.|.|.|       |..|.::...|
Mouse   772 DGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKL-------KMIIAKNGPDT 829

  Fly  5110 DRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            :|||.:|||||.|.||.|.|.:||:..||||| ..::|||
Mouse   830 ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYAKGFG 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	121/375 (32%)
		HECTc	4820..5148	CDD:214523	112/344 (33%)
Ube3a	NP_001380595.1	AZUL	27..81	CDD:406862	19/76 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..223		15/80 (19%)
		HECTc	518..868	CDD:238033	121/377 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810