DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and Hace1

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_006512697.1 Gene:Hace1 / 209462 MGIID:2446110 Length:921 Species:Mus musculus


Alignment Length:819 Identity:242/819 - (29%)
Similarity:365/819 - (44%) Gaps:173/819 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  4393 IHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPT 4457
            ||..|...|:|.....|     |.|:|..:|.:.| :|.|..|..|                  |
Mouse   216 IHSHGQRDTAQILLLRG-----AKYLPDKNGVTPL-DLCVQGGYGQ------------------T 256

  Fly  4458 CELQL-------PSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDI 4515
            ||:.:       .::.::..|...:...||  ::...:....|:|. |....|:|..|..|...:
Mouse   257 CEVLIQYHPRLFQTIVQMTQNEDLRENMLR--QVLQHLSQQSESQY-LKILTGLAEVATTNGHKL 318

  Fly  4516 IDIEGDGGASGGSSSDMAPGS----------ASTISPPPPMETNQIAQDGDDDEEDDDEARSFPG 4570
            :.:        .|:.|....|          ...|.|..|.....:..:|:.             
Mouse   319 LSL--------SSNYDAQMKSLLRIVRIFCHVFRIGPSSPSNGIDMGYNGNK------------- 362

  Fly  4571 VGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVAL--------EESKDEFAVLVLQPTVEAFF 4627
                  ...|:..||       |::||::|.|.||.:        |:|.|..::|:.|       
Mouse   363 ------TPRSQVFKP-------LELLWHSLDEWLVLIATELMKNKEDSTDITSILLKQ------- 407

  Fly  4628 LIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGL----GAAAPSA----QEYSPFMDDVSS 4684
                  :|..:::     |:.:.|   ...|.|:...|    |.:.|..    ||.|....||.|
Mouse   408 ------KGQDQEA-----PSLSAF---EPPGPGSYESLPPGPGDSKPEVLAGEQEASADCQDVIS 458

  Fly  4685 ANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQ 4749
            ......::......|..:....|.:|:|                  :|::|..||..||...:.:
Mouse   459 VTANRLSAVIQAFYMCCSCQMPPGMTSP------------------RFIEFVCKHDEVLKCFVNR 505

  Fly  4750 SPTHLSDGPFAVLVDHTRIL-----------------DFDVKRKYFQTELERLDEG------IRR 4791
            :|        .::.||...|                 .|..:.::|   .|.|..|      :.|
Mouse   506 NP--------KIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWF---YEHLHSGQPDSDMVHR 559

  Fly  4792 ---EEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNP 4853
               |...:.|.|.::|..|..::.:....:.|....:.|..|||. ..|::|||:.|:|.||.||
Mouse   560 PVSENDILLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGM-GQGVVREWFDILSNEIVNP 623

  Fly  4854 MYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQV 4918
            .||||..| .|..|:..|.:|:.||:||:||:|.|:::..|::..:|:..||||||||||||..|
Mouse   624 DYALFTQS-ADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPV 687

  Fly  4919 KHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEY 4983
            .:.|:.|.|.|:.|.|.:::.||||.||.|||||.|...||..:...|||.|....||:.||.||
Mouse   688 NYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEY 752

  Fly  4984 VQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHK- 5047
            ||||.:|:|:.:|:.|::|||:||:..||..||.:|:|.|||||:||:|:||:.|...||||.. 
Mouse   753 VQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSG 817

  Fly  5048 YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRL 5112
            |..:...|||||..:....|.:|...||||||:|:||..||.::.|.:|:|.|.|.....:.:.|
Mouse   818 YEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLL 882

  Fly  5113 PCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
            |.:.||.|.|.||.|.|.:.|:..||.|:|..|.|:..|
Mouse   883 PTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 156/353 (44%)
HECTc 4820..5148 CDD:214523 151/328 (46%)
Hace1XP_006512697.1 ANK repeat 66..95 CDD:293786
Ank_2 69..194 CDD:372319
ANK repeat 97..128 CDD:293786
ANK repeat 130..161 CDD:293786
ANK repeat 163..194 CDD:293786
Ank_2 168..263 CDD:372319 18/70 (26%)
ANK repeat 196..233 CDD:293786 6/21 (29%)
HECTc 566..915 CDD:238033 154/350 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11254
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.