Protein Alignment HUWE1 and Hace1

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_006512697.1
• Gene: Hace1 / 209462
• MGIID: 2446110
• Length: 921
• Species: Mus musculus
• Alignment Length: 819
• Identity: 242/819 - (29%)
• Similarity: 365/819 - (44%)
• Gaps: 173/819 - (21%)

  Fly  4393 IHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPT 4457
            ||..|...|:|.....|     |.|:|..:|.:.| :|.|..|..|                  |
Mouse   216 IHSHGQRDTAQILLLRG-----AKYLPDKNGVTPL-DLCVQGGYGQ------------------T 256

  Fly  4458 CELQL-------PSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDI 4515
            ||:.:       .::.::..|...:...||  ::...:....|:|. |....|:|..|..|...:
Mouse   257 CEVLIQYHPRLFQTIVQMTQNEDLRENMLR--QVLQHLSQQSESQY-LKILTGLAEVATTNGHKL 318

  Fly  4516 IDIEGDGGASGGSSSDMAPGS----------ASTISPPPPMETNQIAQDGDDDEEDDDEARSFPG 4570
            :.:        .|:.|....|          ...|.|..|.....:..:|:.
Mouse   319 LSL--------SSNYDAQMKSLLRIVRIFCHVFRIGPSSPSNGIDMGYNGNK------------- 362

  Fly  4571 VGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVAL--------EESKDEFAVLVLQPTVEAFF 4627
                  ...|:..||       |::||::|.|.||.:        |:|.|..::|:.|
Mouse   363 ------TPRSQVFKP-------LELLWHSLDEWLVLIATELMKNKEDSTDITSILLKQ------- 407

  Fly  4628 LIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGL----GAAAPSA----QEYSPFMDDVSS 4684
                  :|..:::     |:.:.|   ...|.|:...|    |.:.|..    ||.|....||.|
Mouse   408 ------KGQDQEA-----PSLSAF---EPPGPGSYESLPPGPGDSKPEVLAGEQEASADCQDVIS 458

  Fly  4685 ANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQ 4749
            ......::......|..:....|.:|:|                  :|::|..||..||...:.:
Mouse   459 VTANRLSAVIQAFYMCCSCQMPPGMTSP------------------RFIEFVCKHDEVLKCFVNR 505

  Fly  4750 SPTHLSDGPFAVLVDHTRIL-----------------DFDVKRKYFQTELERLDEG------IRR 4791
            :|        .::.||...|                 .|..:.::|   .|.|..|      :.|
Mouse   506 NP--------KIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWF---YEHLHSGQPDSDMVHR 559

  Fly  4792 ---EEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNP 4853
               |...:.|.|.::|..|..::.:....:.|....:.|..|||. ..|::|||:.|:|.||.||
Mouse   560 PVSENDILLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGM-GQGVVREWFDILSNEIVNP 623

  Fly  4854 MYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQV 4918
            .||||..| .|..|:..|.:|:.||:||:||:|.|:::..|::..:|:..||||||||||||..|
Mouse   624 DYALFTQS-ADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPV 687

  Fly  4919 KHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEY 4983
            .:.|:.|.|.|:.|.|.:::.||||.||.|||||.|...||..:...|||.|....||:.||.||
Mouse   688 NYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEY 752

  Fly  4984 VQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHK- 5047
            ||||.:|:|:.:|:.|::|||:||:..||..||.:|:|.|||||:||:|:||:.|...||||..
Mouse   753 VQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSG 817

  Fly  5048 YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRL 5112
            |..:...|||||..:....|.:|...||||||:|:||..||.::.|.:|:|.|.|.....:.:.|
Mouse   818 YEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLL 882

  Fly  5113 PCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
            |.:.||.|.|.||.|.|.:.|:..||.|:|..|.|:..|
Mouse   883 PTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	156/353 (44%)
Hace1	XP_006512697.1	ANKYR	26..261	CDD:440430	18/68 (26%)
		ANK repeat	66..95	CDD:293786
		ANK repeat	97..128	CDD:293786
		ANK repeat	130..161	CDD:293786
		ANK repeat	163..194	CDD:293786
		ANK repeat	196..233	CDD:293786	6/21 (29%)
		HECTc	566..915	CDD:238033	154/350 (44%)