DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and hecd-1

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001368365.1 Gene:hecd-1 / 177486 WormBaseID:WBGene00016405 Length:2650 Species:Caenorhabditis elegans


Alignment Length:3332 Identity:596/3332 - (17%)
Similarity:993/3332 - (29%) Gaps:1154/3332 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  2259 ISRATLLKLLADS-TRAYQSLVPRVLLSHVYTPADSPLISAPQQTFLGVLLDRFLPITQRHHVPE 2322
            :.:..:|.|:||: .|.::|..||                    ||:..|...|:..|...:|.|
 Worm    28 LEQLCMLLLMADNIDRCFESCPPR--------------------TFIPALCKIFIDETAPDNVLE 72

  Fly  2323 VSTMTRVLICSLSDCYQQPGVQVHVAEELHAAVARALAQPDSAEKHTR--LQVLMSLFPNLI--E 2383
            |:.........:|:...:...||..|.:   |:...||..|.:::.::  .:..:.|..::.  |
 Worm    73 VTARAITYYLDVSNECTRRITQVDGAVK---AICTRLAAADISDRSSKDLAEQCVKLLEHVCQRE 134

  Fly  2384 SPMLYD-----------KVH---MHRNNMYRVLLRQGVMTYLTKVAQYKDLSNHNTLSTLAAIL- 2433
            :..:||           :||   :|::.|:..:   .|:|.|....:..|........:|.|:| 
 Worm   135 TMAVYDAGGINAMLTLVRVHGTQVHKDTMHSAM---SVVTRLCGKMEPTDPELGKCAESLGALLE 196

  Fly  2434 ----RPMEILLR-FSVSTTTLGSK------------------RILFGSGGPGGP-NASGN----- 2469
                :..|..|| |:..|.....|                  .|:..|.....| .||.|     
 Worm   197 HEDPKVSESALRCFAALTDRFVRKMMDPAELAMHSNLVEHLISIMVASNDENSPTTASANILSIV 261

  Fly  2470 ----GNNTAGGSSGNGPGSGNTYGTIINRRLYPRLAARTGFGSAMERSNAMGGEHVLRDIIR--- 2527
                ||...|.|             :|..::.......||..:.:....    |.|:.|.:|   
 Worm   262 LSLIGNLCRGSS-------------LITEKVLTSPNMITGLKATLTNKE----ERVVTDGLRFCD 309

  Fly  2528 ---NVLSDRRHAFEFIFNSDDMAVDSEDAAAPGSGVGGGGSGAGSVGGGVSGSVSGNSSAAVIDV 2589
               .:|.:.|.|...      .:|.|.|.||        ||||..|...:..::......|::|.
 Worm   310 LLLVLLCEGRSALPL------TSVVSGDYAA--------GSGAERVHRQLIDAIRQKDLTALVDA 360

  Fly  2590 VEERSNGGDTNDPPANVSSASSGAGQSSTSGGPVRPVVNFDQLWDDFLQSEGLRLASRSGGGAGS 2654
            :|  |...|.|        .:...|||.|:             |                   .|
 Worm   361 IE--SGQVDVN--------FADDVGQSLTN-------------W-------------------AS 383

  Fly  2655 GSGSVGASSSGQQNGSNTTASSTNSGNNSGIGNLRLRTNPDVDVGSGNGSGSGSGSNAGVVNDNG 2719
            ..||:.........||                          ||..|:.|.|          .:.
 Worm   384 AFGSIEMVQYLCDKGS--------------------------DVNKGHKSSS----------LHY 412

  Fly  2720 ISGGGGSDGASTSSDTGAPGGARDLNASLLGDVSTSESDSD--------PSTENDERNEED---E 2773
            .:..|..|........||....||.:.....|.:...||.|        .|.....||:||   :
 Worm   413 AACFGRPDVVKLLLQRGANPDLRDEDGKTALDKARERSDDDHNQVANILESPSAFMRNKEDPKVK 477

  Fly  2774 DEDDDAPDEDV-DEHSETDVDEERSRQFIEVFDHIYEPESSETASNDADVDNDDDDDEDDVDDDD 2837
            ......|.... .|....::..:...|.:.:|..|::                            
 Worm   478 ASTSKQPGTSTKPELPNPNLVRKVLHQLLPIFCEIFQ---------------------------- 514

  Fly  2838 DDDEDNDDDVREEVQSVMDAEIENRIDIALALVSSNNRPRRSAAVNASGDGSANRTN----PDDE 2898
               :..:..||....|:|...:||..|:..:.|...|.|...:|...|.|.||...:    ....
 Worm   515 ---KSLNGSVRRTSLSLMRKIVENIGDLRQSAVGDGNAPAAQSARKMSTDVSAGAESLVAVVVSV 576

  Fly  2899 VDDEDDDVDADPDGDPDVDPI-SGPSAAQAEAYLYE--RLG-----SGLMPTPPVGFRVRMNS-- 2953
            :|.|||.     :|...|..| .......||.::.|  |||     ..:...||.|....:|:  
 Worm   577 MDQEDDH-----EGHEQVLLILESLLEKDAELWVIELVRLGVFERVEAMAKEPPKGLEEVLNAIH 636

  Fly  2954 ----SIAQPLDIDVNGGNAGSGSNAGAT----------GSSGGSGQRSSTGGTTASIGAIASAAL 3004
                |...|::||..  |..|.|.|..|          .||||:...|::..:|           
 Worm   637 LEGRSRVTPMEIDFE--NQPSSSTAVPTANDIMDTTVPSSSGGADAESNSNPST----------- 688

  Fly  3005 RPSSGSWMAPDFNFIRISGGDSSMGSGPAIGGNANGGDMNVFITPSMSLERAGGAP---GSGQTM 3066
                          |.::..:||                    |||.|.:::...|   .|....
 Worm   689 --------------IEMADPESS--------------------TPSSSTQQSISKPKATASSTAS 719

  Fly  3067 SELLNEQPTGAGGGGGGGSASGVGGVGANGGTTGQHPNATLCTNGVRRRLLYLDQQYCVCMPTHQ 3131
            |.:|...          ...|.|..:..:.....:.|..|:.:.|...|                
 Worm   720 SAILQVV----------SKLSSVASLDKSAAAVDKKPTKTVLSQGTPYR---------------- 758

  Fly  3132 NPTEETQMETFTQDALHWWLEEATLLDMESQTDACL-YAA----HFLLPHLIKELKAAHQQRKQE 3191
              .:|.::...|.....|  .:..|:::..|::... |.|    |.   ..:....:..||..:|
 Worm   759 --WKEWRIVRGTTSLFIW--SDVLLIELPFQSNGWFRYLADNDSHV---QFVTGTASVDQQMTEE 816

  Fly  3192 EAARQSTTPASGSNASATS-----SSTTSVVG------TAAPTATSSIASGLLANAVSA------ 3239
            |.          .|...|.     |...:|.|      ::.|.|...|.|.  |..||.      
 Worm   817 EK----------DNFQKTERREMVSRWNAVKGVFDDDWSSVPIAVLGIPSN--AKKVSQKLEVPA 869

  Fly  3240 ----GSGSSSLVVPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPT 3300
                .|.||.|.:..:::||..|...:    ::::......|......||.|..::.......|:
 Worm   870 WELWSSKSSELQIKSISSSAPTGQANT----MLTTIKIQDDAGGFLFETGTGRKTNVMPEHALPS 930

  Fly  3301 RNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEG---DRSTSTTTGTA 3362
            ...:...|:..|..:...|...|:   |:..:|.:.::      |:...|.   .|........|
 Worm   931 DFHTGWSSHGVSTRKMKFRQDIQK---RKVQELAWKLW------NDHLKEAHAKPREALVRLENA 986

  Fly  3363 ADGAESQSQH---NSSSTAAQVAVPQHQR-----------HPPVPLLPSSGRPSRPHTRLDETEL 3413
            |...||..:|   .|:.....|..|:.:|           |..:               :|:..|
 Worm   987 ARTIESTIRHVKAQSNFKHRNVKQPRIERVQEYCAAISTLHESI---------------VDDRRL 1036

  Fly  3414 LLLQLTDRQIRNRLQG------------SSGHTNSSRTSGSAL------INA--RPNRDLPACLQ 3458
            ...:.:...|...|.|            .|.......:.|.||      |.|  ..|...|..| 
 Worm  1037 STFEFSVSGIVPALFGLLSMMEKFPDSFPSRIFKEQFSKGEALSYLALKIVAVLEANEKFPQHL- 1100

  Fly  3459 RHDHPAGSIFPRPSANRTPAPTLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVL 3523
             :|.|.||.|.....:|.....|..:|             .|......|.|....:...|..:.|
 Worm  1101 -YDSPGGSSFGLQLLSRRVRTKLEMLP-------------RADGKENNDENLVNKTGKIVKCEPL 1151

  Fly  3524 PGI----------VDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREES 3578
            ..:          |.....:.:..:.:.:...........:..|.|..|....|.:...||...:
 Worm  1152 ASVGAIRAYLHRMVTRQWHDRERANYRYVKEIQELKTKGKSIELRHVSDFDENGVIYWIGTNGRA 1216

  Fly  3579 SA----PAVATESTEAVNESNQPEPTPESSESTSPNP--------------------QAPSAEPT 3619
            :.    ||.........:::.||...||...|...||                    ..|::...
 Worm  1217 APLWTNPATVKAVKITCSDTRQPFGKPEDLLSRDQNPINCHTSDDKNAHFTIDLGLFVVPTSYSL 1281

  Fly  3620 PLEPG------------AAVDASVGAQTPATTE-----EAASTA----GASGTTATITDMSPEVR 3663
            ....|            .:|||.........|:     |..|||    |..||||          
 Worm  1282 RHSRGYGRSALRNWMLQGSVDAKRWENVIVHTDDKGLGEPGSTATWHVGEKGTTA---------- 1336

  Fly  3664 AALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAAL 3728
                                            .|..||.|..:.::.|          ..:|:..
 Worm  1337 --------------------------------FRFFRIAQNGKNSSGQ----------THYLSCS 1359

  Fly  3729 PLNIQSEVLMQQRIEQQRQAAQTANPEDP--VDTAAFFQNLPENLRQAILTDMEESQIASLPPEL 3791
            ...|..:::         .....|..|||  .|:.|...:.|.:...|.|..:.:.|:..:.|  
 Worm  1360 GFEIYGDIV---------DVVTEAICEDPPKKDSPAGTSSTPGSSSSAALPPLTKEQVLEMLP-- 1413

  Fly  3792 AAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQPQHHQHTTI 3856
                            ||.:.:...:.|| .:|....|..:|..|...|..|.:..         
 Worm  1414 ----------------ARENNNRLKSGLS-LETVTSMLQRSRHRSRGSYKISESKS--------- 1452

  Fly  3857 VHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEP 3921
                                                                  :|:|.      
 Worm  1453 ------------------------------------------------------KVVRG------ 1457

  Fly  3922 TRDWIISALISIIQKTNEDNANFGAGQAGGKPE--WLKLRVDAA------FGYKSNIFLINRLYE 3978
             :||         :..::|......|:....||  |:.:..|..      ||...| |.|.|:..
 Worm  1458 -KDW---------RWEDQDGGEGKFGRITSPPESGWVDVTWDNGNANSYRFGANGN-FDIERVTS 1511

  Fly  3979 GSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFGMPSPTA-GSGGG 4042
            ...|..:.:                 ||.|.|:|.:...|..:|........|.||.:. |:...
 Worm  1512 TGHRYSTPS-----------------LASHVPTSVMEAVRRNRAFYTPKTTGGPPSSSVFGTSSS 1559

  Fly  4043 AGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAA 4107
            |||...|:..|               |||.         |:.:..||..||    ...|:..|..
 Worm  1560 AGSSRGAASAL---------------SRFA---------SVKNTTPAGTPS----SGGSSGGAIG 1596

  Fly  4108 AKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTA 4172
            .|:.:|..:                          :|::.:....:||.   |.|.|      :|
 Worm  1597 KKSMSTTNL--------------------------VDERQKTSGPSVAS---TGQAA------SA 1626

  Fly  4173 DFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPV 4237
            :.|..                  ::|.|.::|.:.:......:.:.:|        |...|:|..
 Worm  1627 ESLQH------------------QTPSLENLLARAMPHAFGRIAENQE--------PEDEPMGGE 1665

  Fly  4238 QRAGAA----AAAAHP-------------------------PPPQPPAENTATATEIGDGLAANI 4273
            :...||    ||:::.                         .|..|..:...|.:.....|||..
 Worm  1666 ESDSAASMRSAASSNSQMSMGSSSQQQQQQDSDMTPRDSAGTPSTPRDDKNQTLSVSAPDLAAAR 1730

  Fly  4274 EEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIY-------------SKNFSQLQ 4325
            :.|||..:    .||::|....::..|:.....:.......:..             |.|.:|.:
 Worm  1731 QRQASAET----DGDADADETNSEDKTVGADDAMEEDDEEEETMEDEEDDDDDDDDESSNENQEK 1791

  Fly  4326 LVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAI-------------------------FIQY 4365
            || |:|    |...||.:..|.::.....|.|||:.                         :...
 Worm  1792 LV-ELL----GGERGLFDKLKEVITGESLSDASSSAKDATTNEAQKKGGKKPKKWFKKMSSYTDV 1851

  Fly  4366 LTAAI-----LGLAEEVRQAIQM--LLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSG 4423
            |...:     :.|.:.....|:|  ::::...|:..:.|..                      .|
 Worm  1852 LKGLMQNRYPVALLDPAAAGIEMDEMMDDDDYYDFSEDGPD----------------------DG 1894

  Fly  4424 ASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCEL------QLPSMKKLMSNSSAQPY-FLRT 4481
            .|:...:|.|.|:..|.| |..|....|...:...||      :..:|.:.:::|...|: ...|
 Worm  1895 DSVEDEVAAHLGMPVDSF-ASMVAARTPITWRQFSELMSGSNRERAAMARAVASSRGSPWEDDAT 1958

  Fly  4482 LK-IFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIE-----GDGGASGGSSSDMAPGSASTI 4540
            :| .|..:...::.:.|.|           |.:..:::|     .|.|::..|||.:........
 Worm  1959 VKCTFEALIPAFDPRPGRS-----------NVNQTLEVELPTVVKDFGSTKASSSKIDKDDQMRF 2012

  Fly  4541 SPPPPMETNQIAQDGDDDEEDDDEARSF--PGVGNHAVASASKSTKPTLSQILCLDVLWN-TLSE 4602
            ....|   |....|....|.:||.|..|  ..:.|::|..|:||.:...        :|. |.|.
 Worm  2013 FLRGP---NMSGVDNVTIEMNDDSASLFRYMQIINNSVNWATKSDRSRR--------IWEPTYSI 2066

  Fly  4603 CLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGA 4667
            |..:.:::..|.:.:                  ..::|......|      :.....|.:..:..
 Worm  2067 CYCSADQTNVEVSKI------------------PDEESSTPCQVN------QCLETIGLLSRIQQ 2107

  Fly  4668 AAPSAQEYSP--FMDD---------------VSSANTPSSAS---------FDDEPR---MQDAS 4703
            |.|.| |.:|  |:.|               |::.:.|...|         |..|.|   ||   
 Worm  2108 AMPEA-EITPNVFISDKLTLKVTQVLSDALVVAARSLPEWCSRLVYKYPCLFTVETRNMYMQ--- 2168

  Fly  4704 TNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLN-QILRQSPTHLSDGPFAVLVDHTR 4767
                     :|:..:|.....|:|.|...::.|.......| ...||               |.|
 Worm  2169 ---------ATAFGVSRTIVWLQQRRDAAVERARGSAQAGNSSAARQ---------------HDR 2209

  Fly  4768 ILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFY-------- 4824
            ..::.|.|             :|.|...|:....|:.:.:.|::          :|:        
 Worm  2210 YHEYRVGR-------------LRHERVKVTRAEETLLDQAIRLM----------KFHADRKAVLE 2251

  Fly  4825 IVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDR-------------------VTYMI 4870
            |.:.:|||...|..| |:|.:::.|:.....||:.....|.                   :.|.:
 Worm  2252 IEYTNEEGTGLGPTL-EFYALVAAELQRKSLALWVCDDDDTHASKSGEEREVDLGEGKKPIGYYV 2315

  Fly  4871 N-----------PSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQV------ 4918
            .           |.:.........|:.:|..:||.:.|.:|::...:|.|.|.::..|:      
 Worm  2316 RRVGGLFPAPLPPGTDETKRAADMFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLVHPQIGDDARG 2380

  Fly  4919 --KHTDMESQDYE--------FYKGL------DYLMKNDIS------------------------ 4943
              .|..:...|:|        |.|.|      ..|::||.|                        
 Worm  2381 PNLHKILSLDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHIKGSTCRV 2445

  Fly  4944 ---TLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLE 5005
               .|.:.:...::|.::...::.|   .|.|..||.:|..:||:...:..::..|..|:.||.:
 Worm  2446 EDLALNFTVNPPSKVFQYAEMELVD---GGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRD 2507

  Fly  5006 GFYDIIPKHLISIFNEQELELLISG--LPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQ 5067
            ||..:.|...:..::.:|::.|:||  .|:...:|:...||.. .||.:|.....|...:.:...
 Worm  2508 GFDRVFPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALTA 2572

  Fly  5068 ADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTD-RLPCAHTCFNQLDLPMYKSYD 5131
            .:|..||||.||.|.:|..|..:|.     .:..|.|...|.| ..|..:||.:.|.||.|.|..
 Worm  2573 QERKNFLQFATGCSSLPPGGLANLH-----PRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSA 2632

  Fly  5132 KLRSCLLKAIHECSEGF 5148
            .||..||.||:|  :||
 Worm  2633 ILRERLLTAINE--KGF 2647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 20/120 (17%)
DUF4414 3675..3779 CDD:291075 16/105 (15%)
HECTc 4796..5149 CDD:238033 99/444 (22%)
HECTc 4820..5148 CDD:214523 94/418 (22%)
hecd-1NP_001368365.1 Ank_2 345..436 CDD:403870 25/168 (15%)
ANK repeat 345..372 CDD:293786 6/36 (17%)
ANK repeat 374..403 CDD:293786 12/86 (14%)
PTZ00322 383..>497 CDD:140343 27/149 (18%)
ANK repeat 405..436 CDD:293786 6/40 (15%)
F5_F8_type_C 1243..1365 CDD:419973 27/173 (16%)
MIB_HERC2 1452..1509 CDD:399589 15/136 (11%)
HECTc 2221..2648 CDD:238033 100/448 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.