Protein Alignment HUWE1 and eel-1

DIOPT Version :9

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001294472.1
• Gene: eel-1 / 177084
• WormBaseID: WBGene00022069
• Length: 4185
• Species: Caenorhabditis elegans
• Alignment Length: 5619
• Identity: 1363/5619 - (24%)
• Similarity: 2139/5619 - (38%)
• Gaps: 1902/5619 - (33%)

  Fly     1 MKVDTVKLKKGS--SELTAECRELIDELTKRRTRAELLEFLD---TVHVWIYGKCELYHWIEILD 60
            ||:|..:....|  |::......|:..:...:...:.:..::   .||. :.||.|||.|.|:|:
 Worm     1 MKIDDAEPSSSSSGSDMPPASATLLRNIVATKNDEDFIAAINKGREVHA-VMGKTELYKWTEVLN 64

  Fly    61 RFDKILEEASRHVNGNEF-VLQCDTNFQETDVTLLLH---VLNFTTLLIEHSFSRHLYNSIEHLT 121
            |.|:|||:|   |:.||| .||||     .|..|..|   ::.||.||.|.:.||.:|.|::.:.
 Worm    65 RCDEILEKA---VHKNEFGNLQCD-----HDTVLKNHAVAIVRFTVLLFECTSSRRIYKSVDRIL 121

  Fly   122 VLLSSQNMDIVLAVLNLLYMFSKRSNFI-PRLPFEKKELLIVKLFNIAERWGDPNYGLSLKDCCI 185
            .||.|.:||::..||.||.:..|||.|: .|:|.:::..|..:|..||:.||.....:.:.:|..
 Worm   122 ALLESTDMDLLAEVLRLLQVMGKRSKFLSTRIPQKEQHALAQRLTAIAQCWGGKLRTVKMAECLK 186

  Fly   186 GEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDLCHTASAPEVIKTIAGQISKP--SEAIKMR--- 245
            .||||..|:.  ..|.|.......:|.|...   ...|..|:|.....|||.|  |:::..:
 Worm   187 REPKLPMLFP--FTYTDAKQRTIIVEQPKFQ---KDESVGELITRTVAQISPPVSSDSVPSQQFS 246

  Fly   246 ------IAHRVRLISGFNNYKLRLQFVQARLQAVSILIYSNALQDNTDK-----VLYAGFGEELC 299
                  :..|||::..|.::..|.:.:..||.:||.|:|...  ..||:     :||:||.||:.
 Worm   247 KEDLYCLLSRVRMLVTFEDWHHRFKCLIVRLLSVSTLVYCRL--GGTDETTLSSLLYSGFIEEIV 309

  Fly   300 ELI--DKE-----DVHLVE-IRAAVLRTLTSMLHFDRNPNVPRAGSRLMKIVHYTGAERQGGTLP 356
            |::  |:|     |.:|.: |:...|.||.|::.:::.|       ::.:|:....|....|.|.
 Worm   310 EMLKSDREADTQQDHNLHDAIQTEALSTLCSIVTYEKEP-------KITQILEALSAGSYHGFLS 367

  Fly   357 LLVRDCIDNLTTH--GLTERYPLILATSLFSLLYHLASYEMGGTALVKSGMMQSLLCVISWPGVD 419
            ::.|..:|.|.::  |.|.:..:.|||:|||.:|||||.|.||..||.||:.|:||.||.:..:.
 Worm   368 VMTRQIVDELKSNNLGKTGKPSVSLATALFSFIYHLASIEPGGDTLVGSGLTQTLLSVIGFHELP 432

  Fly   420 LEHITFVTRAVRVIDLITNIDIARFHQNNGLNVFIDRLEKEIKSCCKA---LADIGITL---KES 478
            :|.|||.||..|:|||.|.||:..|..|||:.:.::|:..||..|.|.   :.||...:   :|.
 Worm   433 IECITFGTRCARIIDLFTTIDVTSFKANNGMEICVNRVVHEINECRKEQPFMIDISYDMPFEEEP 497

  Fly   479 TLRDDHKLDTSLDHVDEDVEDGSGENASVTSGNASPRRDNSSDGATGAGSIVYRAYHEHIGGAGS 543
            ..|||.:       ..|:.||.|.|...|......|
 Worm   498 EPRDDQE-------AHEEPEDESDERNPVDQEAPVP----------------------------- 526

  Fly   544 GAGLLDIGGARSSLSGGSSGTSGMGAGSINRDGSAARPPA--IMYPTNSYYARPLAERKAELSSQ 606
                :::                          .|..|||  |..|.      |:....|..||.
 Worm   527 ----IEV--------------------------DAPLPPASPIAAPA------PVPVASASTSSD 555

  Fly   607 LPSSLAP------KKPSCVTQRAALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANA 665
            ......|      ...:|..||:.|:|.:|.|:|::|.|......|:::||..|.::|.||::||
 Worm   556 SKIKGGPWEEVQMNGATCHQQRSGLIKGLLTFIKRAIGDVQFQDIMKHLMEGDLPEALMHILSNA 620

  Fly   666 EYYGPSLFLLATDVVTVYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALC 730
            |||.||||..:..::|.:|:..|..|||:|...:..|:.::||:|::|.:::|:.:|.|||:|:|
 Worm   621 EYYSPSLFHQSAHLITNFVYQFPEELSSIQRRHVPYVIFQSLLRKELPNSKDVITTLGNVFTAMC 685

  Fly   731 LNERGLFEFLSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADA 795
            ||||||.:|.|||||:::.:::||..:||.:|::||:: :.::|..:|.|:|||::|:|.|:.|.
 Worm   686 LNERGLRQFKSYDPFNQIFRIVLSVKFLVTLRKKRSAE-VFESAQAIGGALDDLMRHYPDLKHDM 749

  Fly   796 TEAIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGSHGGGHHVASTPSPMV-MVAGTGSASSV 859
            .::|:.:|:.|..:|.:|.                    .|...|.:....|. .|..:.:.||:
 Worm   750 LKSIIVILDLLDEIGRNPP--------------------AGVELVPTLTKTMARSVVFSPNNSSL 794

  Fly   860 LQGAA-----------------------------------DTNDSSGDDDDDDDEMSSASQQQQQ 889
            |...|                                   |..||  |.|::|:|||......:.
 Worm   795 LPREAREARELRIQQLQREIPEQADERVGGDVEEEPMEVEDAEDS--DVDEEDNEMSMDEMSGEA 857

  Fly   890 PTTPGQGGGPSTPRTQQAGGVVGSGAGATGTPAAASQAVKVVTPPEREAIPLIDYILNVMKFIEA 954
            |..|.......|...:...|::...|..                  ::.:|:.||:|.:.:.:|.
 Worm   858 PAPPAAPSPKPTKPFEYGAGMMCEDANG------------------KKILPIGDYMLLIARVVET 904

  Fly   955 IFSNSPNGDHCREFVLHGGLKPILQLLSLPNLPVDSPVSTTSQAVANVCKAILS---QAQETKVL 1016
            :.:.||:.....||:....::.|::|..||.:..::..:|...::||:.|.|:.   |:|....
 Worm   905 MMTQSPSQKITEEFIDECVMQKIMKLCHLPCITNEATHATYIGSIANIIKHIVKAGYQSQRNGP- 968

  Fly  1017 DVALKQLADIVAQ----LKPLIKHFTFPGGSVLLAELVCCQRLEDGFANAEYTPILH-------- 1069
            ||..|.::.||.:    :.||.:.......::..||            :.:.|.::|
 Worm   969 DVGPKLMSAIVGEFIKTINPLFEVNNGDFSAMNQAE------------SRKATLLMHLDEKLVEK 1021

  Fly  1070 NMSFVHGYVVMLVHLCRNASN------DMRTILLKRWGVNRETGVQLLQQLVQLYISLVWESTIL 1128
            .:..::..:..|::|.::..:      |.||.:.:.|  ....|::|...|.:|...|.||..::
 Worm  1022 TLVELNSIIPTLLNLNKSPMSSTYNPQDHRTRIYETW--KMPEGMKLYGMLRKLSRMLCWEYELV 1084

  Fly  1129 LNL---------------CSDEPTQ-HPDL----IWDEIAAQMSAAAGTADPLTEAELSRKLERA 1173
            ..|               .||:|.. |.|:    .|||            |.:.|   .:|.:.|
 Worm  1085 QTLKPTIRTAATQTEGEMLSDQPADTHLDVEVMPPWDE------------DSVDE---QQKRDEA 1134

  Fly  1174 AEFRTK---YTPEEQFRYIKS--LLAASSRLGRALAELLGTLVK-LSVGSPQTRQRRINDLISNI 1232
            .|.|.|   .:.||...:||:  |....|:....:.:||.::.| ::|.:|  |:.||.|    .
 Worm  1135 KEPRWKAAGVSQEEHDFWIKNKPLQDIVSKSHAMVKDLLNSMGKTINVNNP--RRPRIRD----T 1193

  Fly  1233 TKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLICSVGFTGPM-------------- 1283
            ..:|...:..|:.|.|||      ::.:..:| |.....        |.||
 Worm  1194 PPLPLAASHCISMIFSSI------YKDLKWEP-PVQNAA--------TSPMAYGRYIELLTQLNH 1243

  Fly  1284 -LFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNVSQKFEFDQWASMEDLMQSHEDDK--- 1344
             ||::.|.:...:...|......|||||:|                             .||
 Worm  1244 SLFENGRCSNPALPQNFYTSGCHKAFFELF-----------------------------SDKIIP 1279

  Fly  1345 ---RDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYM---PDSVPFEPVFYLIHIHQL 1403
               .:.|||..:.::.|.:|..|:.:...::.|.       |:.   ..|..|:...||..:.:.
 Worm  1280 FLGDNMPEGVEQTMEEWCRLAVKLTDRNTIVSSD-------NWQRRDRQSADFDTNKYLKLVCRD 1337

  Fly  1404 AMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQTLLDRYHTRMKEIKFENLYIRSTD---- 1464
            ...|.::             .||.|..:....:||.:.:.:...:..||:. :|| :..|:
 Worm  1338 MFNAYKQ-------------FFEKMAQMPDWELKSLKKVCENAFSVFKEVA-KNL-VEETEATTA 1387

  Fly  1465 --DGLNA---------------------------------------------DHIKTLTDMGFMH 1482
              :.:||                                             |.|..|.|:||..
 Worm  1388 ATEAVNAAAAPAPADAPAAEWGPGALRIPPVAVEPAPAPVAVNPAAAADPHEDTIVMLMDLGFSR 1452

  Fly  1483 YHVIEALRTNASLEEATDYLL-----------NNPEASS-----LSTTGGQSSSSAPPPPPPPSA 1531
            ..|:.||.:..:.:||.:|||           .||....     |...|.:..:.|..|
 Worm  1453 DIVLYALESTRNADEAANYLLAHGNEIPLQDAANPFRDDLLNQVLREAGAEMIAGANTP------ 1511

  Fly  1532 STMDIDVDVPADGESTQSKSSTSPNSSYDYKHLKLMPSLIFDRFCDEAISRAFEFMEAIPD-TVN 1595
            :..:|::.:.|.....|.           |:.:::...::.|...::.   ..:.|||.|| :|:
 Worm  1512 NADEIELQLNAQFAEHQG-----------YELVRIAQRVLRDAGAEQI---GLQIMEAYPDESVD 1562

  Fly  1596 SAADLIA--VLYRRHNHLNKQVFVTNFVRNIIQWVDFTLQLFEPAKTTGSKASRLEECLTGMTAT 1658
            .||:.:.  |:.|..|..      :::..||.|      .|..|....     ::|:.::..:|.
 Worm  1563 VAAEQLINDVMDRVRNPR------SSYEENIAQ------PLIPPLSQL-----KIEQDVSLNSAC 1610

  Fly  1659 R-LFVRLKTSTLLLEENYSDLHRPLVEAITA----------QDAMVSLV--KLLDCMSQWMLEQS 1710
            : ||..:|  .|||..|  |...|..|.|.:          ::.:::.:  :.|..|::.::||.
 Worm  1611 KQLFPLVK--RLLLVSN--DTIHPCAELIVSIFPAMTEEWRKEHLIAEICGEDLKNMAKSLVEQE 1671

  Fly  1711 TETNTGQQRATVPRWVQN---------------LVDLIDA-------IDSISHILQ--------- 1744
            .:.|...::..|.|.:.|               .|..|||       :.|:.::::
 Worm  1672 VDENGRPKQHDVARTMTNRLHFAVLIFDKISEEYVQWIDANGMTEVMLTSLEYLVERFKSVDYYQ 1736

  Fly  1745 ---------------------RKANMRAVS-SDVWRW-------------YDASTGKWNAYSEAN 1774
                                 |:|.::::| |.||.:             |.:...||..|..|:
 Worm  1737 SLITRIICWNDFYAKTHRLIVRRAYLKSLSPSLVWSYQSYEEDALRRRADYSSGEKKWVPYDAAS 1801

  Fly  1775 NELIRNAYAAGERWLYINIGRQRCTVSLNCMTQVSEASGTHRPVCPALKLSEAITSLNNPVALHK 1839
            .:.:.:|:.||.|.:       :||:.              |.|.|..|:.....|:.
 Worm  1802 QKTLNDAFFAGVRGV-------KCTLK--------------RGVRPNKKVDVDFASMK------- 1838

  Fly  1840 VEHILNRVVRTAPDGSGTVHSDELISLRQLVNFTDGQQPQQSENSANPSEEATSEDGPAAANSGS 1904
                         .|.||...:....|
 Worm  1839 -------------QGDGTSRENIKAEL-------------------------------------- 1852

  Fly  1905 PPATMTTRSKTRQKSAAAAAAAKNKSQSGGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDL 1969
            ||....:                       .|.:.....|:..:|:|  ..:|         :||
 Worm  1853 PPTVEVS-----------------------IPDLMDAEAKLSWSEDQ--NDRF---------LDL 1883

  Fly  1970 LQPSHQMLNETKL------SLLRLCARLTRNYDNAQVFIRRGGVRMLLHLQQACSFMGFPTYANI 2028
               |.|:|....|      |:|...|||||::.||..|:.:.||..:|.|:..|: :.:|...:|
 Worm  1884 ---STQILRTGALDPKCSHSMLSFIARLTRSHRNAVRFMEKDGVEAILRLRARCA-ITYPFLVSI 1944

  Fly  2029 ILRHVLEAPPVLQEAMERVL-GMRAAGIVPVG---------HRDLIYVLTQVSSAVSRNPQIFVA 2083
            |:|:.::...:|....|:.: |..|....|..         .:|....|..::...:|||.:|..
 Worm  1945 IIRNCIDDDALLGHIYEKTIRGYIAVPTQPPASMSEYAAGKSKDFADTLNFMAPLSTRNPLVFTE 2009

  Fly  2084 AAKEM--LKGEYLINTNSTTLADDARVMVKSKFGQQPT----AAAGGA-TPHNQTPTPPP----- 2136
            |..::  :.|..::            .|:|.|   :||    :.|||| |..:..|.|||
 Worm  2010 AMNKLARMNGSLIL------------PMIKEK---KPTLSVSSTAGGASTSSSSAPPPPPPLTSS 2059

  Fly  2137 AAKDELKDDPQVQSSVA-VLKELLHGLVQPCWHYGGTGSLDRGQGAAELLQPDQPPGTAQGCHDD 2200
            ::...::::.:.:..|: :|.|:|:|
 Worm  2060 SSHTVVENNSRAEKIVSMMLSEVLNG--------------------------------------- 2085

  Fly  2201 ELYFRFQETPAPVSSKKQSSSGGGAAAAGQTGQATEKFEPCCCTWHIPTSGHTHAKPTISRATLL 2265
                                                         ..||.|.|.   .:|:..:|
 Worm  2086 ---------------------------------------------EFPTVGQTR---MLSQEKIL 2102

  Fly  2266 KLLADSTRAYQSLVPRVLLSHVYTPADSPLISAPQQTFLGVLLDRFL--PITQRHHVPEVSTMTR 2328
            ::||:..::|.||.  ::::.......|.|.|         |:|.::  ||.:......:.|:..
 Worm  2103 QILAEIVKSYPSLA--IIIAETQAEGRSALHS---------LIDTYIIAPIEKIETTNALKTLIA 2156

  Fly  2329 VLICSLSDCYQQPGVQVHV----------AEELHAAVARALAQPDSAEKH--------------T 2369
            |:..|.:....|..:.:.|          |.||...:|:.....:|.|:.              :
 Worm  2157 VISASQNSLKAQELLVLDVKNALASYSEKASELRVDLAKLQLDKESEEREEATTSLKKQETEVLS 2221

  Fly  2370 RLQVLMSLFPNLIESPMLYDKVHMH----RNN--------MYRVLLRQGVMTYLTKVAQYKDLSN 2422
            ::..|.|:...:.:|...:.. |.|    |||        :.::..::.:...|.|......||.
 Worm  2222 KISELCSIIIIMCQSCPAHHH-HHHSSTDRNNRERSSQNAIMKMFHKKRMCADLVKTIHCLQLST 2285

  Fly  2423 HNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGSGGPGGPNASGNGNNTAGGSSGNGPGSGNT 2487
            ..:|.|:..||:.::.||..|.:||:                            ::..||
 Worm  2286 KVSLDTVNQILKTLDTLLEGSTTTTS----------------------------ATITGP----- 2317

  Fly  2488 YGTIINRRLYPRLAARTGFGSAMERSNAMGGEHVLRDIIRNVLSDRRHAFEFIFNSDDMAVDSED 2552
                  |.|...:|.|    ....|..|.||          ::::|.  .:.||..|.:|.|.|
 Worm  2318 ------RSLMDIVAGR----REQRREAAAGG----------IMNERE--IDTIFQRDGLAFDGE- 2359

  Fly  2553 AAAPGSGVGGGGSGAGSVGGGVSGSVSGNSSAAVIDVVEERSNGGDTNDPPANVSSASSGAGQSS 2617
                                              ::.:..|..|.....     :|...||||.:
 Worm  2360 ----------------------------------MENLLRRLQGDHWRG-----NSVQRGAGQVA 2385

  Fly  2618 TSGGPVRPVVNFDQLWDDFLQSEGLRLASRSGGGAGSGSGSVGASSSGQQNGSNTTASSTNSGNN 2682
            .                                               ::.||.|......|
 Worm  2386 E-----------------------------------------------EEEGSETYEERERS--- 2400

  Fly  2683 SGIGNLRLRTNPDVDVGSGNGSGSGSGSNAG--VVNDNGISGGGGSDGASTSSDT--GAPGGARD 2743
                                .|.|.|..:||  .|.|:.:..|.|....:.:.|.  .||.....
 Worm  2401 --------------------DSPSESSEHAGDEEVRDDAVETGDGEVDMADAQDAPLAAPDAPPG 2445

  Fly  2744 LNASLLGDVSTSESDSDPSTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERSRQFIEVFDHIY 2808
            :|.            .|...:..:|:.||::||:|.   |.:||...:.|.:|
 Worm  2446 INL------------VDEIMQQVQRDVEDDEEDEDG---DQNEHEAEEDDHDR------------ 2483

  Fly  2809 EPESSETASNDADVDNDDDDDEDDVDDDDDDDEDNDDDVREEVQSVMDAEIENRIDIALALVSSN 2873
                     .|.| |.|||||||:.::.:|||:| :||||.                    |..|
 Worm  2484 ---------EDED-DEDDDDDEDEEEEAEDDDQD-EDDVRH--------------------VEQN 2517

  Fly  2874 NRPRRSAAVNASGDGSANRTNPDDEVDDEDDDVDADPDG----------DPDVDPISGPSAAQAE 2928
            ..|            .|.|...:|:.|:||||.|.|.|.          |.|...:.||..||
 Worm  2518 PEP------------LARRLFEEDDDDEEDDDGDEDGDSMEDDVQRLDLDDDYFDMGGPFDAQ-- 2568

  Fly  2929 AYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGSGQRSSTGGTT 2993
                                 ||:..|..|
 Worm  2569 ---------------------RMDDMIFPP----------------------------------- 2577

  Fly  2994 ASIGAIASAALRPSSGSW---MAPDFNFIRISGGDSSMGSGPAIGGNANGGDMNVFITPSMSLER 3055
             |.|       ||:..|:   ...||:|:                          |..|....||
 Worm  2578 -SFG-------RPAVTSFADLFRDDFDFL--------------------------FSRPPYRAER 2608

  Fly  3056 AGGAPGSGQTMSELLNEQPTGAGGGGGGGSASGVGGVGANGGTTGQHPNATL--CTNGVRRRLLY 3118
            ...|.||..                               ||...:||..|.  ..|.|.||
 Worm  2609 RPLARGSHL-------------------------------GGVISEHPLMTRPPAENDVSRR--- 2639

  Fly  3119 LDQQYCVCMPTHQNPTEETQMETFTQDALHWWLEEATLLDMESQTDACLYAAHFLLPHLIKELKA 3183
                     |......|..||.  |:.:||
 Worm  2640 ---------PNTNIRAEILQMH--TRSSLH----------------------------------- 2658

  Fly  3184 AHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVV 3248
                  ::.|.|::||.|....|                     |:.|:....:.||    .::|
 Worm  2659 ------RQNAIRRTTTEARELEA---------------------ISRGIRMGELPAG----RMLV 2692

  Fly  3249 PPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPTRNFSSVDSNVSSE 3313
            ........||...|....:..  :.||:.:.:.|               |..|::::.|.:
 Worm  2693 RGTTTHGDGGVHTSFFDHIFD--IRPSNVAFSRS---------------GAYRSYNTGDRD---- 2736

  Fly  3314 TQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADGAESQ--SQHNSSS 3376
                     :|..:| .||:|                          |..:..||.  |....||
 Worm  2737 ---------ERRDIR-ASQVP--------------------------TCLERLESYSLSMEPVSS 2765

  Fly  3377 TAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSG 3441
            ....|.|..|.              ::.|.           ..:.||:...:..:.....:..:.
 Worm  2766 RFVTVIVNSHL--------------NKIHA-----------AREAQIKKEAEIKAKAKKDAEAAK 2805

  Fly  3442 SALINARPNRDLPA---CLQRHDHPAGSIFPRPSANRTPAPTLVSMPTPMSNAALEQLNVTAPDV 3503
            .|..:.:...:.||   ..::.|.||....|      .|||..:.:.||   ||....|..:..|
 Worm  2806 KAAEDKKKAAEAPAPAPSAEQSDSPASPDAP------APAPEEIGLATP---AATNTTNTVSESV 2861

  Fly  3504 -----VRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDD 3563
                 .|.|.....|::.:|              |.|..:||.:          :..|:...|||
 Worm  2862 APNASTRGDDTLTTPAAAQV--------------EDQASEDQHI----------EEEPMEVGEDD 2902

  Fly  3564 LWPGTVVSAGTREESSAPAVA-TESTEAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAAV 3627
               |...:..:...::|.:|| ||..|.|......:..||..::....|...:.|..|
 Worm  2903 ---GAAEAPQSSAATAASSVAGTEEIEDVERQAVEDHVPEIQDNDDTLPYEGAVEHAP------- 2957

  Fly  3628 DASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVI 3692
                 ||.|   ||..              |..|.||.|||:.:|:||||:||||||.|||.|||
 Worm  2958 -----AQAP---EENV--------------MPEEFRAILGDIIIPDGVDPAFLAALPEEMRAEVI 3000

  Fly  3693 QEHLRMQRIRQ----------------------------RAQQNAIQIAHDSLVE-VNPEFLAAL 3728
            :::.|.||..:                            :|:|.|..:.  .||| ::|.||.||
 Worm  3001 RDYQRQQRAERASRPVPAAQPVAVNPNAPAGGEAAQGEGQAEQPAAAVV--PLVEPIDPVFLNAL 3063

  Fly  3729 PLNIQSEVL------MQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQIASL 3787
            |..:|.|||      :::..||||:......|...:|.||...:||.|.|..:|.:|:::::|.|
 Worm  3064 PPELQEEVLAEHERRLREAEEQQRRQNAPPAPVVEMDGAAVIASLPANERAQVLAEMDDAELAGL 3128

  Fly  3788 PPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQPQHHQ 3852
            |.::..||:..|..           |...|.|             |:|..::....|.|...
 Worm  3129 PADMQNEARRARAQ-----------HVEPNML-------------RYHRLLFRGGVGGAPGA--- 3166

  Fly  3853 HTTIVHQHPHAHHAPNMGKPL------ALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHR 3911
             ...|....:|..|.|.|..:      |:....|:..|||.:|:.||.|...|::.:|...||.:
 Worm  3167 -IGTVRARTNARAAANAGPSVGQNAGNAIQAPPDQPHLLDRESILTLCLLYLVDNNRVPHTRLQK 3230

  Fly  3912 VIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRL 3976
            |:|:.|.::.|.|:|:..|::::.|.:|.|.: ........|.||.....:..|:......|:.
 Worm  3231 VLRSACVNQTTCDFIVWCLLALLDKASEANTD-DEEILSNVPAWLDSIAVSGVGHNERAIRISE- 3293

  Fly  3977 YEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFGMPSPTAGSGG 4041
               :|:.|||:...|..:.:|.||||..:|:.||.:|:|.        ||.
 Worm  3294 ---NAQKISIHSMLAIPMCKNILDLLANIARAYPGNFLPL--------ILR-------------- 3333

  Fly  4042 GAGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAA 4106
                                                         |.| ||:....:|||.::
 Worm  3334 ---------------------------------------------HGA-KPTDTPKQAPSFAQ-- 3350

  Fly  4107 AAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNT 4171
                                         ||.:|           .|..:.|.:..  |...|..
 Worm  3351 -----------------------------FWTMV-----------QNTTKVPKSKD--WTATPEQ 3373

  Fly  4172 ADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEE-ELLPLSDQMPPLVPIG 4235
                ...|.|.||:|..|...::.:|| |.:.::|:.:.:...||.:. :||...:...||.
 Worm  3374 ----QLEECPLGQMLNSLRKPIMAKSP-LKEKVLKVASQIMVTLPMDTLKLLGNDESRKPLA--- 3430

  Fly  4236 PVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPT 4300
                                                                             
 Worm  3431 ----------------------------------------------------------------- 3430

  Fly  4301 LSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGL-DNVAKLIVNLTQCSQASSAIFIQ 4364
                                 .:|:.||:|:|....:|||| |.:..|...:...|.::|....:
 Worm  3431 ---------------------EKLEFVIQVMTTGSCSTEGLADGLTILSEAMRSLSDSTSVDIYE 3474

  Fly  4365 YLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPN 4429
            :|..|:..|..|:...:..|:.|:   :..|.....:|.|.|....::.||..|...|.|.
 Worm  3475 HLFLAVSKLGGELLPQVDRLIVEL---DEAQKKEEVSSVAPSDQPTSSKTAQLVVDTSAAG---- 3532

  Fly  4430 LAVHEGIMQDRFTAEHVIISAPKNAK---PTC-ELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRD 4490
                 .:...||..|.::|...:|.:   .:| |||||::..|.....||...|..|:..::||:
 Worm  3533 -----RVATGRFDGERLVIDGDQNMRLQMSSCKELQLPAVTVLTDKGGAQYALLSALQTLVKVRN 3592

  Fly  4491 MYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSAST--ISPPPPMETNQIAQ 4553
            ..:|     .....|..|.|.:..:  .|.:..::...::..||.:|.|  .:|..|:|.|::.:
 Worm  3593 HMKA-----IRKDKAKRAKDAEKKL--KEKETPSTSAPAAPAAPATAPTAPAAPDAPVENNEVPE 3650

  Fly  4554 DGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQIL-CLDVLWNTLSECLVALEESKDEFAVL 4617
            ...:.||.:||                   :|.:|:.| .|:.|||:|||||:.|.::.|..|||
 Worm  3651 PAAELEEVNDE-------------------EPRISERLSSLESLWNSLSECLLRLGKASDPHAVL 3696

  Fly  4618 VLQPTVEAFFLIHASHRG--------ASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQE 4674
            .|||..|||||:|||.:.        |.:|..::...:||                 ||..|:..
 Worm  3697 ALQPAAEAFFLVHASQQNKLKAKDAEAKRKESQAASSSAA-----------------AAVASSVS 3744

  Fly  4675 YSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKH 4739
            :....:|:                            :|.|:               |.::|||||
 Worm  3745 HDGLREDL----------------------------DPDTA---------------KLIEFAEKH 3766

  Fly  4740 RTVLNQILRQSPTHLS-DGPFAVLVDHTRILDFDVKRKYFQTELERLDEG------IRREEHTVS 4797
            |.||||.|||:...|| .||||:|....::||||||||||:.||.:|:..      .||.:.:|.
 Worm  3767 RQVLNQALRQNNAVLSAGGPFAILTQFPKLLDFDVKRKYFRKELTKLEPSNSRMPRYRRNDVSVQ 3831

  Fly  4798 VRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSP 4862
            |.|..||.||||.|:||.|.||||||||:|:.|||||||||||||:.:|:||||||.||||..:|
 Worm  3832 VSRNRVFSDSFRELFRLRPSEWKNRFYIIFQGEEGQDAGGLLREWFSVITREIFNPNYALFITAP 3896

  Fly  4863 GDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQD 4927
            ||.||||||.:|:.||.||.|||||||:|||:|.::|.|:|||||:||||||...|::.|:||:|
 Worm  3897 GDMVTYMINKASYINPEHLDYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESED 3961

  Fly  4928 YEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKM 4992
            ..|:|.||:|::|.|..|..:|||||||:||||..:||||||||...|.:.||.|||:||||:||
 Worm  3962 PAFFKSLDFLLQNPIDDLALDLTFSTEVEEFGVRSVRDLKPNGRKIEVNDANKDEYVKLVCQMKM 4026

  Fly  4993 SGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQW 5057
            :||||:||||||.|||:||||.|||:||||||||||||||.:||:|:.|||:|..:...|..|||
 Worm  4027 TGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDYKGFQKTSTHIQW 4091

  Fly  5058 FWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQL 5122
            ||||||||::.|:||||||||||||||||||.|||||||:|||.||.|.|..||||.||||||||
 Worm  4092 FWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQL 4156

  Fly  5123 DLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
            |||.|:||:|||..||.||.||:||||||
 Worm  4157 DLPQYESYEKLRQSLLLAIRECTEGFGFA 4185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630	80/263 (30%)
		DUF913	621..989	CDD:283642	113/403 (28%)
		UBA_like_SF	1467..1506	CDD:304366	16/94 (17%)
		WWE	1756..1828	CDD:128922	17/84 (20%)
		40S_SA_C	3575..3651	CDD:292740	17/76 (22%)
		DUF4414	3675..3779	CDD:291075	47/138 (34%)
		HECTc	4796..5149	CDD:238033	243/352 (69%)
		HECTc	4820..5148	CDD:214523	227/327 (69%)
eel-1	NP_001294472.1	DUF908	95..376	CDD:283630	83/294 (28%)
		DUF913	573..936	CDD:283642	114/403 (28%)
		UBA_VP13D	1442..1476	CDD:270491	13/33 (39%)
		WWE	1787..1846	CDD:295449	19/99 (19%)
		DUF4414	2983..3120	CDD:291075	47/138 (34%)
		HECTc	3830..4183	CDD:238033	243/352 (69%)
		HECTc	3854..4182	CDD:214523	227/327 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160719
Domainoid	1	1.000	443	1.000	Domainoid score	I274
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1317	1.000	Inparanoid score	I69
Isobase	1	0.950	-	0	Normalized mean entropy	S7112
OMA	1	1.010	-	-		QHG55621
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	1	1.000	-	-		FOG0008080
OrthoInspector	1	1.000	-	-		oto20401
orthoMCL	1	0.900	-	-		OOG6_101783
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5722
SonicParanoid	1	1.000	-	-		X3469
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.850